2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
This is an abbreviated version!
For detailed information about galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.135
-
2.4.1.135
-
glycosaminoglycans
-
proteoglycans
-
glcat-s
-
killer-1
-
tetrasaccharide
-
trisaccharide
-
glycosaminoglycan-protein
-
n-acetyllactosamine
-
glucuronylation
-
udp-glca
-
hnk-1st
-
galbeta1-3glcnac
-
b3gat3
-
paragloboside
-
non-sulfated
- 2.4.1.135
- glycosaminoglycans
- proteoglycans
- glcat-s
-
killer-1
- tetrasaccharide
- trisaccharide
-
glycosaminoglycan-protein
- n-acetyllactosamine
-
glucuronylation
- udp-glca
-
hnk-1st
- galbeta1-3glcnac
-
b3gat3
- paragloboside
-
non-sulfated
Reaction
Synonyms
beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, GlcATI, GlcUAT-I, glucuronosyltransferase I, glucuronyltransferase-I, glycosaminoglycan glucuronyltransferase I, glycosyltransferases GlcAT1, UDP-GlcUA:Gal Beta-1,3-Gal-R glucuronyltransferase, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, UDP-glucuronic acid:Galbeta1,3Gal-R glucuronsyltransferase
ECTree
2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP
-
-
-
-
?
Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xylbeta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xylbeta1-O-Ser + UDP
-
-
-
-
?
Galbeta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP
-
-
-
-
?
Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser + UDP
-
-
-
-
?
UDP-alpha-D-glucuronate + Galbeta1,3Galbeta-O-naphthalenemethanol
?
-
-
-
?
UDP-alpha-D-glucuronate + Galbeta1,3GalNAcbeta-O-naphthalenemethanol
?
-
-
-
?
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
-
-
-
?
UDP-Gal + Galbeta(1-3)Gal
Galbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, weak activity with mutant enzyme H308R
-
-
?
UDP-galacturonic acid + Galbeta(1-3)Gal
Galbeta(1-3)Galbeta(1-3)Gal + UDP
-
-
-
?
UDP-GlcNAc + Galbeta(1-3)Gal
GlcNAcbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, activity with mutant enzyme H308R is nearly equal to activity with UDP-Glc
-
-
?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP-glucuronate + Galbeta(1-3)Gal
GlcAbeta(1-3)Galbeta(1-3)Gal + UDP
-
-
-
?
UDP-glucuronate + Galbeta(1-3)Gal(6-sulfate)beta1-O-methoxyphenyl
UDP + ?
-
-
-
?
UDP-glucuronate + Galbeta(1-3)Gal-O-benzyl
UDP + ?
best substrate
-
-
?
UDP-glucuronate + Galbeta(1-3)Gal-O-naphthalenemethanol
UDP + ?
best substrate
-
-
?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
-
-
-
-
?
UDP-glucuronate + Galbeta(1-3)GlcNAcalpha-O-naphthalenemethanol
UDP + ?
-
-
-
?
UDP-glucuronate + Galbeta(1-3)GlcNAcbeta-O-naphthalenemethanol
UDP + ?
-
-
-
?
UDP-glucuronate + Galbeta(1-4)Glcbeta-O-naphthalenemethanol
UDP + ?
-
-
-
?
UDP-glucuronate + Galbeta(1-4)GlcNAcbeta-O-naphthalenemethanol
UDP + ?
-
-
-
?
UDP-glucuronate + Galbeta-O-1-naphthol
UDP + GlcAbeta(1-3)Galbeta-O-1-naphthol
-
-
-
?
UDP-glucuronate + Galbeta-O-2-naphthol
UDP + GlcAbeta(1-3)Galbeta-O-2-naphthol
-
-
-
?
UDP-glucuronate + Galbeta1-3Gal
UDP + Galbeta1-3Galbeta1-3Gal
-
the enzyme exhibits a strict selectivity towards Galbeta1-3Gal structures
-
-
?
UDP-Man + Galbeta(1-3)Gal
Manbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, efficient reaction with mutant enzyme H308R
-
-
?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
UDPglucuronate + 3-beta-D-galactosyl-D-galactosyl-4-xylose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactosyl-4-xylose
-
-
-
?
UDPglucuronate + 3-beta-D-galactosyl-D-galactosyl-4-xylosylserine
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactosyl-4-xylosylserine
-
-
-
?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
-
-
-
?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
plays a key role in glycosaminoglycan biosynthesis
-
-
?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
-
-
-
-
?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
-
high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope
-
-
?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
?
-
involved in the biosynthesis of the polysaccharide-protein-linkage region of proteochondroitin sulfate
-
-
?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
?
-
involved in the biosynthesis of the heparin-polypeptide linkage region
-
-
?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
-
transfer to non-reducing terminal
-
?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
-
-
-
?
additional information
?
-
-
mutant lacking glucuronosyltransferase I fails to make both heparan sulfate and chondroitin sulfate
-
-
?
additional information
?
-
no activity with Galalpha-O-p-nitrophenol, Galbeta-O-p-nitrophenol, Galalpha-O-a-naphthol, GalNAcalpha-O-p-nitrophenol, GalNAcbeta-O-p-nitrophenol
-
-
?
additional information
?
-
-
no activity with Galalpha-O-p-nitrophenol, Galbeta-O-p-nitrophenol, Galalpha-O-a-naphthol, GalNAcalpha-O-p-nitrophenol, GalNAcbeta-O-p-nitrophenol
-
-
?
additional information
?
-
analysis of glycan structure by mass spectrometry. Activity analysis of enzyme splicing variants, overview
-
-
-
additional information
?
-
-
the uridine diphosphate binding region plays an important role in enzyme activity of the enzyme
-
-
?
additional information
?
-
-
galactosyl-beta-1,6-galactose is a less effective acceptor substrate
-
-
?
additional information
?
-
-
galactosyl-beta-1,4-galactose is a less effective acceptor substrate
-
-
?
additional information
?
-
-
negligible activity with Galbeta(1-3)galbeta1-O-benzyl, galbeta(1-4)GlcNAc and galbeta(1-4)Glc
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
-
-
?
additional information
?
-
the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
-
-
?
additional information
?
-
-
the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
-
-
?
additional information
?
-
-
enzyme is involved in heparan sulfate and chondroitin sulfate biosynthesis
-
-
?
additional information
?
-
-
central enzyme in the initial steps of proteoglycan synthesis
-
-
?
additional information
?
-
enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
-
-
?
additional information
?
-
-
enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
-
-
?
additional information
?
-
the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
-
-
?
additional information
?
-
-
the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
-
-
?
additional information
?
-
no activity with wild-type enzyme: UDP-Glc, IDP-Gal, UDP-Man and UDP-GlcNAc
-
-
?
additional information
?
-
-
no activity with wild-type enzyme: UDP-Glc, IDP-Gal, UDP-Man and UDP-GlcNAc
-
-
?
additional information
?
-
-
no substrate Gal(6-O-sufate)beta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser
-
-
?
additional information
?
-
-
no substrate Gal(6-O-sufate)beta(1-3)Galbeta(1-4)Xylbeta1-O-Ser
-
-
?
additional information
?
-
-
galactosyl-beta-1,4-xylose, galactosyl-beta-1,4-glucose is a less effective acceptor substrate
-
-
?
additional information
?
-
-
galactosyl-beta-1,6-galactose is a less effective acceptor substrate
-
-
?
