2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
This is an abbreviated version!
For detailed information about galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.135
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2.4.1.135
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glycosaminoglycans
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proteoglycans
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glcat-s
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killer-1
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tetrasaccharide
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trisaccharide
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glycosaminoglycan-protein
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n-acetyllactosamine
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glucuronylation
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udp-glca
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hnk-1st
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galbeta1-3glcnac
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b3gat3
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paragloboside
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non-sulfated
- 2.4.1.135
- glycosaminoglycans
- proteoglycans
- glcat-s
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killer-1
- tetrasaccharide
- trisaccharide
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glycosaminoglycan-protein
- n-acetyllactosamine
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glucuronylation
- udp-glca
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hnk-1st
- galbeta1-3glcnac
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b3gat3
- paragloboside
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non-sulfated
Reaction
Synonyms
beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, GlcATI, GlcUAT-I, glucuronosyltransferase I, glucuronyltransferase-I, glycosaminoglycan glucuronyltransferase I, glycosyltransferases GlcAT1, UDP-GlcUA:Gal Beta-1,3-Gal-R glucuronyltransferase, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, UDP-glucuronic acid:Galbeta1,3Gal-R glucuronsyltransferase
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2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
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-
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?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
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plays a key role in glycosaminoglycan biosynthesis
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-
?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
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high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope
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-
?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
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?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
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involved in the biosynthesis of the polysaccharide-protein-linkage region of proteochondroitin sulfate
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?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
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involved in the biosynthesis of the heparin-polypeptide linkage region
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?
additional information
?
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mutant lacking glucuronosyltransferase I fails to make both heparan sulfate and chondroitin sulfate
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?
additional information
?
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the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
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?
additional information
?
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the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
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?
additional information
?
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the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
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?
additional information
?
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enzyme is involved in heparan sulfate and chondroitin sulfate biosynthesis
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?
additional information
?
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central enzyme in the initial steps of proteoglycan synthesis
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?
additional information
?
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enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
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?
additional information
?
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enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
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?
additional information
?
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the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
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?
additional information
?
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the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
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?
