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2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.135

Reaction

UDP-alpha-D-glucuronate
+
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
=
UDP
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, GlcATI, GlcUAT-I, glucuronosyltransferase I, glucuronyltransferase-I, glycosaminoglycan glucuronyltransferase I, glycosyltransferases GlcAT1, UDP-GlcUA:Gal Beta-1,3-Gal-R glucuronyltransferase, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, UDP-glucuronic acid:Galbeta1,3Gal-R glucuronsyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

General Information

General Information on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
dGlcAT-P null mutants larvae show lower expression of glucuronylated T antigen on the muscles and at neuromuscular junctions (NMJs). Mislocalization of NMJ boutons and a partial loss of the basement membrane components collagen IV (Col IV) and nidogen (Ndg) at the muscle 6/7 boundary are observed. The phenotypes correlate to previously described phenotypes in dC1GalT1 mutant larvae. dGlcAT-P null mutants exhibit fewer NMJ branches on muscles 6/7 compared to wild-type. Basement membranes that lack Col IV and Ndg are significantly deformed. The loss of dGlcAT-P expression causes ultrastructural defects in NMJ boutons. Genetic interaction between dGlcAT-P and dC1GalT1 is determined. Phenotypes of dGlcAT-P mutants, detailed overview
metabolism
physiological function
additional information
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gene B3GAT3 is a unigene, pathway enrichment analysis of assembled unigenes, overview. Identification of markers of NK cells. Enzyme structure modelling using the structure of human GlcAT-P as a template