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2.4.1.133: xylosylprotein 4-beta-galactosyltransferase

This is an abbreviated version!
For detailed information about xylosylprotein 4-beta-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.133

Reaction

UDP-alpha-D-galactose
+
[protein]-3-O-(beta-D-xylosyl)-L-serine
=
UDP
 +
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine

Synonyms

B4GALT7, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 7, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-T7, beta-1,4-GalT, beta-1,4-GalT 7, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase VII, beta1,4-galactosyltransferase-7, beta1,4-GalT, beta1,4-GalT-I, beta1,4-GalT7, beta4-galactosyltransferase 7, beta4Gal-T7, beta4galactosyltransferase I, beta4GalT-7, beta4GalT7, dbeta4GalTI, galactosyltransferase I, galactosyltransferase, uridine diphosphogalactose-xylose, GalT I, GalT-I, hbeta4GalT7, MgGalT7, pNP-xylose-beta-1,4-galactosyltransferase, proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I, SQV-3, UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, xylosylprotein 4-beta-galactosyltransferase, xylosylprotein beta1,4-galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.133 xylosylprotein 4-beta-galactosyltransferase

Expression

Expression on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush, in situ hybridization shows that at day 1 after sciatic nerve crush, the expression levels of beta-1,4-GalT I mRNA is strong at the crush site, and decreases gradually from crush site to the distal segments, the expression of beta-1,4-GalTI mRNA is related to the injury site and injury time in peripheral nervous system
-
beta-1,4-GalT V mRNA reaches peaks at 2 weeks after sciatic nerve crush, in situ hybridization shows that at day 1 after sciatic nerve crush, the expression levels of beta-1,4-GalT V mRNA is strong at the crush site, and decreases gradually from crush site to the distal segments
-
beta-1,4-GalT-I is strongly induced in the ventral midbrain by intranigral injection of lipopolysaccharide, significant increase in beta-1,4-GalT-I mRNA at 8 h after focal injection of lipopolysaccharide, and lastes to 18 h, then decreases gradually
-
beta-1,4-GalT-I mRNA is significant increased as early as 2 h after lipopolysaccharide stimulation (1 microM/ml), upregulation in a time- and concentration-dependent manner
-
both anti-TNFR1 and anti-TNFR2 antibodies suppressed beta-1,4-GalT I mRNA expression induced by tumor necrosis factor-alpha or lipopolysaccharide
decreasing of the expression of GalT I in hepatoma cells reduce the ability of tumor formation in vivo and inhibits hepatitis B virus-encoded protein HBx-induced cell cycle progression
GalT I is highly expressed in hepatocellular carcinoma and transcriptionally up-regulated by hepatitis B virus-encoded HBx, and functions as a positive growth regulator in hepatoma cells
in injured spinal cords, enzyme is significantly increased after 8 h, beta-1,4-GalT-I mRNA reaches the peak at 1 day after spinal cord contusion, then gradually reduced from day 5 to day 7, recovers to the baseline level at 14 day
-
the beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush and 3 days after sciatic nerve transection in a dose-dependent manner, in inflammation, lipopolysaccharide administration affects beta-1,4-GalT I mRNA expression in sciatic nerve in a time- and dose-dependent manner, and beta-1,4-GalT I mRNA is expressed mainly in Schwann cells
-
the expression level of beta-1,4-GalT I mRNA in cultured type-2 astrocytes is dose-dependent compared with the control group, it decreases at 0.1 ng/ml tumor necrosis factor-alpha, reaches at a peak at 1 ng/ml and then restores to normal level at 5 ng/ml. The expression in cultured type-2 astrocytes is time-dependent, it increases from 0.5 h, peaks at 4 h, then it decreases gradually to normal level after exposure to 1 ng/ml tumor necrosis factor-alpha. Lipopolysaccharide induces beta-1,4-GalT I mRNA expression in type-2 astrocytes in a time- and dose-dependent manner