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2.4.1.109: dolichyl-phosphate-mannose-protein mannosyltransferase

This is an abbreviated version!
For detailed information about dolichyl-phosphate-mannose-protein mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.109

Reaction

dolichyl beta-D-mannosyl phosphate
+
L-seryl-[protein]
=
dolichyl phosphate
+
3-O-(alpha-D-mannosyl)-L-seryl-[protein]

Synonyms

AapmtA, AfPmt1p, AnPmtA, AnPmtB, AnPmtC, dolichol phosphomannose-protein mannosyltransferase, dolichyl phosphate-mannose:protein O-mannosyltransferase, dolichyl-phosphate-mannose--protein mannosyltransferase 1, dolichyl-phosphate-mannose--protein mannosyltransferase 2, dolichyl-phosphate-mannose--protein mannosyltransferase 4, dolichyl-phosphate-mannose-protein mannosyltransferase, dolichyl-phosphate-mannose-protein mannosyltransferase 1, dolichyl-phosphate-mannose-protein mannosyltransferase 2, Drosophila O-mannosyltransferase Rotated Abdomen, Drosophila O-mannosyltransferase Twisted, HpPmt1p, mannosyltransferase, dolichol phosphomannose-protein, More, O-glycoside mannosyltransferase, O-mannosyltransferase, O-mannosyltransferase 1, ogm1, ogm2, ogm4, Oma1, Oma2, Oma4, Omg1, Omg2, Omg4, PMT, PMT1, Pmt1 O-mannosyltransferase, Pmt1A, Pmt1D, Pmt1p, Pmt1p-Pmt2p, PMT2, Pmt2A, Pmt2D, Pmt2p, PMT3, PMT4, Pmt4A, Pmt4D, Pmt4p, PMT5, Pmt5p, Pmt6, PMT7, PmtA, pmtB, pmtC, PMTI, POMT1, POMT2, protein mannosyltransferase, protein O-D-mannosyltransferase, protein O-mannosyl-transferase 1, protein O-mannosyl-transferase 2, protein O-mannosyltransferase, protein O-mannosyltransferase 1, protein O-mannosyltransferase 2, protein O-mannosyltransferase A, protein O-mannosyltransferase Pmt4, protein O-mannosyltransferases 1, protein O-mannosyltransferases 2, protein-O-mannosyltransferase-1, protein-Omannosyltransferase, RT, sPOMT2, tPOmt2, TW, Um05433, Um10749, Um11220

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.4.1.109 - dolichyl-phosphate-mannose-protein mannosyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]
dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-seryl-[protein]
show the reaction diagram
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]
dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
show the reaction diagram
dolichyl phosphate D-mannose + alpha-dystroglycan
dolichyl phosphate + O-D-mannosyl-[alpha-dystroglycan]
show the reaction diagram
-
in vitro asssay with both enzyme isoforms (RT and TW), 20 mM Tris, pH 8.0, mercaptoethanol, EDTA, n-octyl-beta-D-thioglucoside, sugar donor is tritium-labeled, alpha-dystroglycan isoform C contains mucin-type domain that is target of O-mannose modifications in mammals, high grade of O-mannosylation, A isoform without noticeable O-mannosylation, rabbit alpha-dystroglycan as positive control shows lower O-mannosylation
-
-
?
dolichyl phosphate D-mannose + glucoamylase I
dolichyl phosphate + O-D-mannosyl glucoamylase I
show the reaction diagram
the AaPmtA protein is involved in the formation of the normal cell wall. AaPmtA protein is responsible for the transfer of mannose to glucoamylase I
-
-
?
dolichyl phosphate D-mannose + protein
dolichyl phosphate + O-D-mannosylprotein
show the reaction diagram
dolichyl phosphate D-mannose + protein Aga2
dolichyl phosphate + O-D-mannosylprotein Aga2
show the reaction diagram
dolichyl phosphate D-mannose + protein AN5660
dolichyl phosphate + O-D-mannosylprotein
show the reaction diagram
the un-glycosylated 32 kDa protein is an ortholog of Wsc family proteins in Saccharomyces cerevisiae, these proteins serve as sensors of stress, such as high temperature and cell wall-perturbing chemicals
AN5660
-
?
dolichyl phosphate D-mannose + protein Bar1
dolichyl phosphate + O-D-mannosylprotein Bar1
show the reaction diagram
dolichyl phosphate D-mannose + protein chitinase 1
dolichyl phosphate + O-D-mannosylprotein chitinase 1
show the reaction diagram
dolichyl phosphate D-mannose + protein Ggp1/Gas1
dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1
show the reaction diagram
dolichyl phosphate D-mannose + protein Kex2
dolichyl phosphate + O-D-mannosylprotein Kex2
show the reaction diagram
dolichyl phosphate D-mannose + protein Kre9
dolichyl phosphate + O-D-mannosylprotein Kre9
show the reaction diagram
dolichyl phosphate D-mannose + protein Pir2/hsp150
dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150
show the reaction diagram
dolichyl phosphate D-mannose + ribonuclease 2
dolichyl phosphate + ribonuclease 2-D-mannose
show the reaction diagram
additional information
?
-