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2.4.1.102: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.102

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
=
UDP
+
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]

Synonyms

2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-, A, bC2GnT-M, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, beta-1,6-N-acetylglucosaminyltransferase, beta1,6-N-acetylglucosaminyltransferase, beta6-N-acetylglucosaminyltransferase, Bo17, C2 beta6GnT1, C2/4GnT, C24GNT, C2GlcNAcT-I, C2GlcNAcT-II, C2GlcNAcT-III, C2GnT, C2GnT-1, C2GnT-I, C2GnT-L, c2GnT-M, C2GnT1, C2GnT2, C2GnT3, C2GNTM, C4GnT, core 2 acetylglucosaminyltransferase, core 2 beta-1, 6-N-acetylglucosaminyltransferase-1, core 2 beta-1,6 N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2 beta1,6 N-acetylglucosaminyltransferase, core 2 beta1,6 N-acetylglucosaminyltransferase-I, core 2 beta1,6-N-acetyl-glycosaminyltransferase, core 2 beta1,6-N-acetylglucosaminyl transferase 1, core 2 beta1,6-N-acetylglucosaminyltransferase, core 2 beta1,6-N-acetylglucosaminyltransferase I, core 2 beta1,6-N-acetylglucosaminyltransferase-I, core 2 beta6-GlcNAc-transferase, core 2 beta6-N-acetylglucosaminyltransferase, core 2 GlcNAc-T, core 2 N-acetylglucosaminyltransferase, Core 2 N-acetylglucosaminyltransferase 2/M, core 2 N-acetylglucosaminyltransferase M, core 2 N-acetylglucosaminyltransferase-1, core 2 N-acetylglucosaminyltransferase-M, core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type, core 2beta 1,6 N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, core 6-beta-GlcNAc-T, core 6-beta-GlcNAc-transferase A, core2 1-6-N-glucosaminyltransferase-I, core2 beta(1,6)-N-acetyglucosaminyltransferase-I, core2 beta-1,6-N-acetylglucosaminyltransferase, core2 beta-1,6-N-acetylglucosaminyltransferase-1, Core2beta1,6GnT type M, core2GnT, GCNT1, gcnt3, gcnt4, GnT-III, GNTM, More, mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme, mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1-6)-acetylglucosaminyltransferase A

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Source Tissue

Source Tissue on EC 2.4.1.102 - beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
an EBVnGC cell line
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
GCNT3 is elevated in skin and mesothelioma cells and in some lung and breast cancer cells
Manually annotated by BRENDA team
differential expression of GCNT3 gene among tumour samples from stage II colon cancer patients by quantitative reverse-transcription PCR, overview
Manually annotated by BRENDA team
GCNT3 gene expression is downregulated in colorectal cancer (CRC) samples in comparison to non-pathological colon tissue
Manually annotated by BRENDA team
-
maturation of dendritic cells leads to a rapid change in the expression of glycosyltransferases involved in O-linked glycosylation. A down-regulation of C2GnT1 mRNA and enzymatic activity is observed with a concurrent up-regulation of ST3Gal I and ST6GalNAc II mRNA resulting in a loss of the core 2 structures required for sLex expression as a P-selectin ligand
Manually annotated by BRENDA team
-
expression of C2GnT1 in 84 cases of endometrioid-type endometrial carcinoma, 15 cases of endometrial hyperplasia, and 30 normal endometria, immunohistochemic analysis, overview. C2GnT1 is strongly expressed at the invasive tumour front in several cases
Manually annotated by BRENDA team
GCNT3 expression analysis in a cohort of 56 EOC patients, followed by a meta-analysis of more than one thousand patients, overview
Manually annotated by BRENDA team
GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
-
NCI498, ileo-caecal carcinoma cell line
Manually annotated by BRENDA team
-
transcription of core 2 beta1,6 N-acetylglucosaminyltransferase-I is controlled by Sp1 in lymphocytes and epithelial cells
Manually annotated by BRENDA team
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erythroleukemia cell line
Manually annotated by BRENDA team
-
pre-B lymphocytic leukemia cell line
Manually annotated by BRENDA team
-
colonic adenocarcinoma cell line
Manually annotated by BRENDA team
-
YC2C2 lymphocytic leukemia cell line
Manually annotated by BRENDA team
GCNT3 is overexpressed in highly metastatic melanomas
Manually annotated by BRENDA team
GCNT3 is highly expressed in both NSCLC tissues and cell lines
Manually annotated by BRENDA team
an EBVnGC cell line
Manually annotated by BRENDA team
an EBVaGC cell line
Manually annotated by BRENDA team
-
colonic grade II tumour cell line
Manually annotated by BRENDA team
-
colonic grade III tumour cell line
Manually annotated by BRENDA team
-
colonic large ulcerating grade IV tumour cell line, low activity
Manually annotated by BRENDA team
-
CD8 T cell
Manually annotated by BRENDA team
high content
Manually annotated by BRENDA team
additional information