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2.3.3.9: malate synthase

This is an abbreviated version!
For detailed information about malate synthase, go to the full flat file.

Word Map on EC 2.3.3.9

Reaction

acetyl-CoA
+
glyoxylate
 +
H2O
=
(S)-malate
 +
CoA

Synonyms

EC 4.1.3.2, GCE, GCE(13-573), glcB, glyoxylate cycle enzyme, glyoxylate transacetase, glyoxylic transacetase, L-malate glyoxylate-lyase (CoA-acetylating), malate synthase, malate synthase 1, malate synthase A, malate synthase G, malate synthase H, malate synthetase, malic synthetase, malic-condensing enzyme, MLS, MSA, MSG, MSH, SSO1334

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.9 malate synthase

pH Range

pH Range on EC 2.3.3.9 - malate synthase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10
-
85% activity
5 - 9.5
-
pH 5.0: about 35% of maximal activity, pH 9.5: about 70% of maximal activity
6.8 - 9.7
-
pH 6.8 and 9.7: about 50% of maximal activity, phosphate-citrate-borate buffer
7
-
87% activity
7 - 10
-
pH 7.0: about 40% of maximal activity, pH 10.0: about 45% of maximal activity
7 - 8.5
-
pH 7.0: about 80% of maximal activity, pH 8.7: about 60% of maximal activity, enzyme form MSL and MSH
7.5 - 10.5
-
pH 7.5: about 55% of maximal activity, pH 10.5: about 25% of maximal activity, enzyme form MSL and MSH
7.5 - 8.5
malate synthase reaction
8 - 10
additional information
-
below pH 6: no activity remains, outside pH 7-10 the activity decreases rapidly