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2.3.3.8: ATP citrate synthase

This is an abbreviated version!
For detailed information about ATP citrate synthase, go to the full flat file.

Word Map on EC 2.3.3.8

Reaction

ADP
+
phosphate
 +
acetyl-CoA
 +
oxaloacetate
=
ATP
 +
citrate
 +
CoA

Synonyms

ACL, ACL1, ACL2, ACLA, ACLB, ACLY, adenosine triphosphate citrate lyase, ATP citrate (pro-S)-lyase, ATP citrate lyase, ATP citrate lyase isoform 2, ATP-citrate lyase, ATP-citrate synthase A-2, ATP-citrate synthase alpha chain protein 2, ATP-citric lyase, ATP:citrate lyase, ATP:citrate oxaloacetate lyase ((pro-3S)-CH2COO--> acetyl-CoA) (ATP-dephosphorylating), ATP:citrate oxaloacetate-lyase (pro-3S-CH2COO->acetyl-CoA, ATP dephosphorylating), ATP:citrate oxaloacetate-lyase CoA-acetylating and ATP-dephosphorylating, Citrate cleavage enzyme, citrate-ATP lyase, citric cleavage enzyme, Earlier Degraded Tapetum1, EC 4.1.3.8, EDT1, Os11g0696200

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.8 ATP citrate synthase

Source Tissue

Source Tissue on EC 2.3.3.8 - ATP citrate synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
the enzyme is specifically expressed in the tapetum of anthers
Manually annotated by BRENDA team
normal and osteoarthritis human knee chondrocytes and cartilages
Manually annotated by BRENDA team
strong expression
Manually annotated by BRENDA team
normal and osteoarthritis human knee chondrocytes
Manually annotated by BRENDA team
-
as well as in autotrophically grown cells
Manually annotated by BRENDA team
-
as well as in autotrophically grown cells
Manually annotated by BRENDA team
ACLY deficiency in hepatocytes protects from hepatic steatosis and dyslipidemia
Manually annotated by BRENDA team
-
ATP citrate lyase-deficient INS-1 cells, which are unable to convert citrate into cytosolic acetyl-CoA, insulin release by 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid is decreased and adding beta-hydroxybutyrate or alpha-ketoisocaproate, which increases mitochondrial acetoacetate, normalizes 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid-induced insulin release
Manually annotated by BRENDA team
additional information