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2.3.3.8: ATP citrate synthase

This is an abbreviated version!
For detailed information about ATP citrate synthase, go to the full flat file.

Word Map on EC 2.3.3.8

Reaction

ADP
+
phosphate
+
acetyl-CoA
+
oxaloacetate
=
ATP
+
citrate
+
CoA

Synonyms

ACL, ACL1, ACL2, ACLA, ACLB, ACLY, adenosine triphosphate citrate lyase, ATP citrate (pro-S)-lyase, ATP citrate lyase, ATP citrate lyase isoform 2, ATP-citrate lyase, ATP-citrate synthase A-2, ATP-citrate synthase alpha chain protein 2, ATP-citric lyase, ATP:citrate lyase, ATP:citrate oxaloacetate lyase ((pro-3S)-CH2COO--> acetyl-CoA) (ATP-dephosphorylating), ATP:citrate oxaloacetate-lyase (pro-3S-CH2COO->acetyl-CoA, ATP dephosphorylating), ATP:citrate oxaloacetate-lyase CoA-acetylating and ATP-dephosphorylating, Citrate cleavage enzyme, citrate-ATP lyase, citric cleavage enzyme, Earlier Degraded Tapetum1, EC 4.1.3.8, EDT1, Os11g0696200

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.8 ATP citrate synthase

Activating Compound

Activating Compound on EC 2.3.3.8 - ATP citrate synthase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetate
-
activates
antizyme
-
antizyme 1 and 2 activate the enzyme through protein-protein interaction
-
Cl-
-
activates
D-fructose 1,6-diphosphate
-
activates
D-fructose 2,6-diphosphate
-
activates
D-fructose 6-phosphate
-
potent activator of the unphosphorylated recombinant enzyme, half-maximal activation at 0.16 mM
D-glucose 1-phosphate
-
activates
D-glucose 6-phosphate
-
activates
D-ribulose 5-phosphate
-
activates
D-xylulose 5-phosphate
-
activates
HCO3-
-
activates
insulin growth factor 1
-
induces enzyme activation in an AKT-dependent fashion
-
phosphoenolpyruvate
-
activates
additional information
-
6-8 very reactive sulfhydryl groups appear to be essential for activity
-