2.3.3.13: 2-isopropylmalate synthase
This is an abbreviated version!
For detailed information about 2-isopropylmalate synthase, go to the full flat file.
Word Map on EC 2.3.3.13
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2.3.3.13
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l-leucine
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4.1.3.12
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alpha-ketoisovalerate
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homocitrate
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beta-isopropylmalate
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citramalate
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methylthioalkylmalate
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alpha-ketobutyrate
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alpha-ketoisocaproate
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feedback-resistant
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acetohydroxyacid
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acetohydroxy
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accoa
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medicine
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agriculture
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drug development
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food industry
- 2.3.3.13
- l-leucine
-
4.1.3.12
- alpha-ketoisovalerate
- homocitrate
- beta-isopropylmalate
- citramalate
-
methylthioalkylmalate
- alpha-ketobutyrate
- alpha-ketoisocaproate
-
feedback-resistant
-
acetohydroxyacid
-
acetohydroxy
- accoa
- medicine
- agriculture
- drug development
- food industry
Reaction
Synonyms
2-isopropylmalate synthase 1, chloroplastic, 2-isopropylmalate synthase 2, chloroplastic, 3-hydroxy-4-methyl-3-carboxy-pentanoate 2-oxo-3-methyl-butanoate lyase (CoA-acetylating), 3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methyl-butyrate lyase (CoA-acetylating), alpha-IPM synthase, Alpha-IPM synthetase, alpha-IPMS, alpha-IPMS-14CR, alpha-IPMS-2CR, Alpha-isopropylmalate synthase, alpha-isopropylmalate synthase I, alpha-isopropylmalate synthase II, alpha-isopropylmalate synthetase, alpha-isopropylmalic synthetase, BatIMS, EC 4.1.3.12, IPM synthase, IPM-synthase, IPMS, IPMS1, IPMS2, IPMS3, isopropylmalate synthase, isopropylmalate synthase 1, isopropylmalate synthetase, LEU4, LEU9, leuA, Mj1195, MtalphaIPMS, MtIPMS, NmeIPMS, Os11g04670, Os12g04440, OsIPMS1, OsIPMS2, ROL17, synthase, 2-isopropylmalate, synthase, alpha-isopropylmalate, TT_C0849
ECTree
2.3.3.13 2-isopropylmalate synthaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.3.3.13 - 2-isopropylmalate synthase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.734
4-methylthio-2-oxobutyrate
isoform IPMS3, pH and temperature not specified in the publication
0.012
2-oxo-3-methylbutanoate
apparent value, full-length enzyme, in 50 mM HEPES (pH 7.5), at 25°C
0.03
2-oxo-3-methylbutanoate
apparent value, full-length enzyme, in 50 mM HEPES (pH 7.5), at 25°C
0.06
2-oxo-3-methylbutanoate
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with acetyl-CoA as cosubstrate
0.143
2-oxoisovalerate
isoform IPMS1, pH and temperature not specified in the publication
0.215
2-oxoisovalerate
isoform IPMS3, pH and temperature not specified in the publication
0.005
3-methyl-2-oxobutanoate
mutant enzyme D444A, at pH 7.5 and 25°C
0.008
3-methyl-2-oxobutanoate
mutant enzyme R97A, at pH 7.5 and 25°C
0.009
3-methyl-2-oxobutanoate
mutant enzyme D444R, at pH 7.5 and 25°C
0.015
3-methyl-2-oxobutanoate
wild type enzyme, at pH 7.5 and 25°C
0.016
3-methyl-2-oxobutanoate
mutant enzyme D444Y, at pH 7.5 and 25°C
0.0095
acetyl-CoA
mutant E218A, enzyme displays substrate activation, unactivated form
0.035
acetyl-CoA
apparent value, full-length enzyme, in 50 mM HEPES (pH 7.5), at 25°C
0.136
acetyl-CoA
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cosubstrate 2-oxo-3-methylbutanoate, pH 7.4, 25°C
0.136
acetyl-CoA
apparent value, full-length enzyme, in 50 mM HEPES (pH 7.5), at 25°C
0.697
acetyl-CoA
mutant E218A, enzyme displays substrate activation, activated form
0.0016
alpha-ketoisovalerate
mutant E218A, enzyme displays substrate activation, unactivated form
0.0016
alpha-ketoisovalerate
mutant H379A, enzyme displays substrate activation, unactivated form
0.019
alpha-ketoisovalerate
mutant H379A, enzyme displays substrate activation, activated form
0.039
alpha-ketoisovalerate
mutant E218A, enzyme displays substrate activation, activated form
additional information
additional information
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Km of enzyme with and without Zn2+ or Mn2+
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