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2.3.2.B8: E2:E3 ubiquitin transferase

This is an abbreviated version!
For detailed information about E2:E3 ubiquitin transferase, go to the full flat file.

Word Map on EC 2.3.2.B8

Reaction

S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine
+
[HECT-E3-ubiquitin-carrier protein]-L-cysteine
=
[ubiquitin-carrier protein E2]-L-cysteine
+
S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine

Synonyms

E2-E3 ligase, E3 HECT, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase Itchy homolog, Itch, UbcH5, UbcH5B-ubiquitin-HECT NEDD4L complex, UbcH6, UbcM3, UBE2D1, UBE2E1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.B8 E2:E3 ubiquitin transferase

Substrates Products

Substrates Products on EC 2.3.2.B8 - E2:E3 ubiquitin transferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
[ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
show the reaction diagram
-
-
-
-
?
S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein]-L-cysteine
[ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine
show the reaction diagram
[ubiquitin-carrier protein UbcH5]-S-ubiquitinyl-L-cysteine + [HECT-E3-ubiquitin-carrier protein E6-AP]-L-cysteine
[ubiquitin-carrier protein UbcH5]-L-cysteine + [HECT-E3-ubiquitin-carrier protein E6-AP]-S-ubiquitinyl-L-cysteine
show the reaction diagram
a region of isoform UbcH5 encompassing the catalytic site cysteine residue is critical for its ability to interact with E3 enzymes E6-AP and RSP5. Of particular importance is a phenylalanine residue at position 62 of UbcH5 that is conserved among the members of the UBC4/UBC5 subfamily but is not present in any of the other known E2s
-
-
?
[ubiquitin-carrier protein UbcH5]-S-ubiquitinyl-L-cysteine + [HECT-E3-ubiquitin-carrier protein Rsp5]-L-cysteine
[ubiquitin-carrier protein UbcH5]-L-cysteine + [HECT-E3-ubiquitin-carrier protein Rsp5]-S-ubiquitinyl-L-cysteine
show the reaction diagram
a region of isoform UbcH5 encompassing the catalytic site cysteine residue is critical for its ability to interact with E3 enzymes E6-AP and RSP5. Of particular importance is a phenylalanine residue at position 62 of UbcH5 that is conserved among the members of the UBC4/UBC5 subfamily but is not present in any of the other known E2s
-
-
?
additional information
?
-