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2.3.2.B8: E2:E3 ubiquitin transferase

This is an abbreviated version!
For detailed information about E2:E3 ubiquitin transferase, go to the full flat file.

Word Map on EC 2.3.2.B8

Reaction

S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine
+
[HECT-E3-ubiquitin-carrier protein]-L-cysteine
=
[ubiquitin-carrier protein E2]-L-cysteine
+
S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine

Synonyms

E2-E3 ligase, E3 HECT, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase Itchy homolog, Itch, UbcH5, UbcH5B-ubiquitin-HECT NEDD4L complex, UbcH6, UbcM3, UBE2D1, UBE2E1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.B8 E2:E3 ubiquitin transferase

Reference

Reference on EC 2.3.2.B8 - E2:E3 ubiquitin transferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nuber, U.; Scheffner, M.
Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction
J. Biol. Chem.
274
7576-7582
1999
Homo sapiens (P51668), Homo sapiens, Mus musculus (P52482)
Manually annotated by BRENDA team
Kamadurai, H.B.; Souphron, J.; Scott, D.C.; Duda, D.M.; Miller, D.J.; Stringer, D.; Piper, R.C.; Schulman, B.A.
Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex
Mol. Cell.
36
1095-1102
2009
Homo sapiens (P62837), Homo sapiens (Q96PU5)
Manually annotated by BRENDA team
Riling, C.; Kamadurai, H.; Kumar, S.; OLeary, C.E.; Wu, K.P.; Manion, E.E.; Ying, M.; Schulman, B.A.; Oliver, P.M.
Itch WW domains inhibit its E3 ubiquitin ligase activity by blocking E2-E3 ligase trans-thiolation
J. Biol. Chem.
290
23875-23887
2015
Mus musculus (Q8C863)
Manually annotated by BRENDA team
Schumacher, F.R.; Wilson, G.; Day, C.L.
The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly
J. Mol. Biol.
425
4099-4111
2013
Homo sapiens
Manually annotated by BRENDA team
Banka, P.A.; Behera, A.P.; Sarkar, S.; Datta, A.B.
RING E3-catalyzed E2 self-ubiquitination attenuates the activity of Ube2E ubiquitin-conjugating enzymes
J. Mol. Biol.
427
2290-2304
2015
Homo sapiens
Manually annotated by BRENDA team
Zhu, K.; Shan, Z.; Chen, X.; Cai, Y.; Cui, L.; Yao, W.; Wang, Z.; Shi, P.; Tian, C.; Lou, J.; Xie, Y.; Wen, W.
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
EMBO Rep.
18
1618-1630
2017
Mus musculus (Q8C863), Homo sapiens (Q96J02)
Manually annotated by BRENDA team