2.3.2.B8: E2:E3 ubiquitin transferase
This is an abbreviated version!
For detailed information about E2:E3 ubiquitin transferase, go to the full flat file.
Reaction
Synonyms
E2-E3 ligase, E3 HECT, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase Itchy homolog, Itch, UbcH5, UbcH5B-ubiquitin-HECT NEDD4L complex, UbcH6, UbcM3, UBE2D1, UBE2E1
ECTree
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General Information
General Information on EC 2.3.2.B8 - E2:E3 ubiquitin transferase
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physiological function
part of the E1-E2-E3 ubiquitin conjugation cascade. The E2-ubiquitin covalent complex interacts with an E3 (HECT) for ubiquitin transfer. Ubiquitin is transferred to the acceptor cysteine of the C-lobe of the HECT domain
physiological function
itch ligase activities are controlled via autoinhibition. Aberrant activation of Itch leads to migration defects of cortical neurons during development