2.3.2.B8: E2:E3 ubiquitin transferase
This is an abbreviated version!
For detailed information about E2:E3 ubiquitin transferase, go to the full flat file.
Reaction
Synonyms
E2-E3 ligase, E3 HECT, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase Itchy homolog, Itch, UbcH5, UbcH5B-ubiquitin-HECT NEDD4L complex, UbcH6, UbcM3, UBE2D1, UBE2E1
ECTree
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Engineering
Engineering on EC 2.3.2.B8 - E2:E3 ubiquitin transferase
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additional information
generation of chimeric E2 enzymes consisting of different parts of human UbcH5 and murine UbcM3. Chimera consist of the N-terminal 62 amino acids of UbcH5 fused to the C-terminal 85 amino acids of UbcM3 and of the N-terminal 108 amino acids of UbcM3 fused to the C-terminal 85 amino acids of UbcH5, respectively. The ability to interact with E3 enzyme E6-AP maps to the C-terminal 85 amino acids of UbcH5 and particularly to a phenylalanine residue at position 62 of UbcH5 that is conserved among the members of the UBC4/UBC5 subfamily but is not present in any of the other known E2 enzymes
additional information
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generation of chimeric E2 enzymes consisting of different parts of human UbcH5 and murine UbcM3. Chimera consist of the N-terminal 62 amino acids of UbcH5 fused to the C-terminal 85 amino acids of UbcM3 and of the N-terminal 108 amino acids of UbcM3 fused to the C-terminal 85 amino acids of UbcH5, respectively. The ability to interact with E3 enzyme E6-AP maps to the C-terminal 85 amino acids of UbcH5 and particularly to a phenylalanine residue at position 62 of UbcH5 that is conserved among the members of the UBC4/UBC5 subfamily but is not present in any of the other known E2 enzymes
additional information
generation of chimeric E2 enzymes consisting of different parts of human UbcH5 and murine UbcM3. Chimera consist of the N-terminal 62 amino acids of UbcH5 fused to the C-terminal 85 amino acids of UbcM3 and of the N-terminal 108 amino acids of UbcM3 fused to the C-terminal 85 amino acids of UbcH5, respectively. The ability to interact with E3 enzyme E6-AP maps to the C-terminal 85 amino acids of UbcH5