2.3.2.B14: L,D-transpeptidase
This is an abbreviated version!
For detailed information about L,D-transpeptidase, go to the full flat file.
Word Map on EC 2.3.2.B14
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2.3.2.B14
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tuberculosis
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mycobacterium
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carbapenems
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penicillin-binding
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d,d-transpeptidases
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enterococcus
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faecium
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ldtmt2
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transpeptidases
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imipenem
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ertapenem
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muropeptides
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acylenzyme
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clavulanate
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transpeptidation
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d-ala
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lineage-determining
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doripenem
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d,d-carboxypeptidase
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analysis
- 2.3.2.B14
- tuberculosis
- mycobacterium
- carbapenems
-
penicillin-binding
-
d,d-transpeptidases
- enterococcus
- faecium
- ldtmt2
- transpeptidases
- imipenem
- ertapenem
- muropeptides
-
acylenzyme
- clavulanate
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transpeptidation
- d-ala
-
lineage-determining
- doripenem
- d,d-carboxypeptidase
- analysis
Reaction
Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala4 bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap3 of the donor stem and the side chain of mDap3 of the acceptor stem. =
Synonyms
CLIBASIA_01175, IprQ, L,D-transpeptidase, L,D-transpeptidase 2, L,D-transpeptidase 5, LdtB, LdtBS, LdtF, Ldtfm, Ldtfm217, Ldtfs, LdtMt1, LdtMt2, LdtP, MAB_1530, MAB_3165c, MT0125, MT0501, MT2594, Rv1433, Rv2518c, transpeptidase, YcbB
ECTree
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Engineering
Engineering on EC 2.3.2.B14 - L,D-transpeptidase
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C354A
H336A
no cysteine acylation by inhibitors can be detected in a 0-500-s time frame
H352A
mutation does not show a decrease in the rate of the acylation reaction by inhibitors
C354A
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mutant does not display adduct formation with inhibitors faropenem or 6-aminopenicillanic acid
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H336A
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no cysteine acylation by inhibitors can be detected in a 0-500-s time frame
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H352A
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mutation does not show a decrease in the rate of the acylation reaction by inhibitors
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D353A
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meropenem preferentially acylates the mutant in a competition experiment
D353N
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meropenem preferentially acylates the mutant in a competition experiment
D353W
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meropenem preferentially acylates the mutant in a competition experiment. Substitution nearly abolishes acylation by biapenem but does not affect acylation by faropenem, doripenem, or meropenem
C354A
mutant does not display adduct formation with inhibitors faropenem or 6-aminopenicillanic acid