2.3.2.27: RING-type E3 ubiquitin transferase
This is an abbreviated version!
For detailed information about RING-type E3 ubiquitin transferase, go to the full flat file.
Word Map on EC 2.3.2.27
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2.3.2.27
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brca2
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ovarian
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women
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proteasome
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germline
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hereditary
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ligases
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pink1
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tumour
-
mitophagy
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tumorigenesis
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checkpoint
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adaptor
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polyubiquitination
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neurodegenerative
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parp
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estrogen
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counsel
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chromatin
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high-risk
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histone
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predisposition
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pten
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early-onset
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rad51
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founder
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ubiquitin-proteasome
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serous
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dopaminergic
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prophylactic
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sumo
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triple-negative
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ubiquitin-mediated
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mastectomy
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proteasome-dependent
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ubiquitin-dependent
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basal-like
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ubiquitin-like
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xiap
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sumoylation
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fanconi
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ubiquitin-conjugating
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deubiquitinating
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alpha-synuclein
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medicine
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mammography
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first-degree
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analysis
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polycomb
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fork
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centrosome
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chk1
- 2.3.2.27
- brca2
- ovarian
- women
- proteasome
-
germline
- hereditary
- ligases
- pink1
- tumour
-
mitophagy
- tumorigenesis
-
checkpoint
- adaptor
-
polyubiquitination
- neurodegenerative
- parp
- estrogen
-
counsel
- chromatin
-
high-risk
- histone
-
predisposition
- pten
-
early-onset
- rad51
-
founder
-
ubiquitin-proteasome
- serous
-
dopaminergic
-
prophylactic
- sumo
-
triple-negative
-
ubiquitin-mediated
-
mastectomy
-
proteasome-dependent
-
ubiquitin-dependent
-
basal-like
-
ubiquitin-like
- xiap
-
sumoylation
-
fanconi
-
ubiquitin-conjugating
-
deubiquitinating
- alpha-synuclein
- medicine
-
mammography
-
first-degree
- analysis
-
polycomb
- fork
- centrosome
- chk1
Reaction
Synonyms
ABA-insensitive RING protein3, abscisic acid-insensitive RING protein 4, ACRE276, AIR1, AIR2, AIRP1, AIRP2, AIRP3, AIRP4, AMFR, Arabidopsis ABA-insensitive RING protein 1, Arabidopsis ABA-insensitive RING protein 2, ARIH1, As-induced RING E3 ligase 2, At1g54150, At1g74410, At2g15580, At4g23450, At4g26400, ATL2, ATL80, Avr9/Cf-9 rapidly elicited protein 276, BIG BROTHER, BIRC3, BRCA1, BRE1A, BRE1B, breast cancer susceptibility protein 1, breast cancer type 1 susceptibility protein, c-Cbl, C3HC4-RING finger E3 ubiquitin ligase, CaRING1, CHIP, cIAP2, Cop1, COP1 SUPPRESSOR1, CSU1, CUL4, cullin-4, DAF, DEAR1, DEFECTIVE IN ANTHER DEHISCENCE1 (DAD1)-activating factor, Der3, Dir1, E3 ligase, E3 ubiquitin ligase, E3 ubiquitin ligase Erysiphe necator-induced RING finger protein 1, E3 ubiquitin ligase RING1, E3 ubiquitin-protein ligase Arkadia, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase MIR1, E3 ubiquitin-protein ligase RNF25, E3-enzyme, EIRP1, EMR, ERAD-associated E3 ubiquitin-protein ligase DOA10, ERAD-associated E3 ubiquitin-protein ligase HRD1, ERAD-mediating RING finger protein, FANCL, gamma rays-induced RING finger protein1, GIRP1, gp78, H2-10, HCI1, HHARI, HIR1, HOS1, HSPC238, HTAS, HUB1, Human Homologue of Drosophila Ariadne, IDF1, IRT1 degradation factor1, KEEP ON GOING, KEG, Kf-1, LOG2, mahogunin ring finger-1, MARCH10, MARCH6, Mdm2, MEX3C, MGRN1, microtubule-associated E3 ubiquitin ligase isoform 1, MIEL1, MUL1, NERF, NFYA5 enhancing RING FINGER, Os05g41795, Os10g30850, Parkin, Parkinson juvenile disease protein 2, PIR1, PIR2, Pirh2, PLANT U-BOX17, PP2CA interacting RING finger protein 1, PP2CA interacting RING finger protein 2, pre-mRNA-splicing factor 19, PRP19, PUB17, PUB54, RanBP-type and C3HC4-type zinc finger-containing protein 1, RBCK1, RBX1, RCHY1, RFP1, RFPH2-10, RGLG2, RHA2b, Rines, Ring, RING E3, RING E3 ubiquitin ligase, ring finger protein 103, Ring finger protein 186, RING finger ubiquitin E3 ligase, RING-CH 10, ring-finer protein 55, RING-finger E3 ligase, RING-finger E3 ubiquitin ligase, RING-finger ubiquitin ligase Ubr1, RING-H2 finger E3 ubiquitin ligase, RING-H2 finger protein ATL63, RING-IBR-RING ubiquitin ligase, RING-type E3 ligase, RING-type E3 ubiquitin ligase, Ring1B, RMA1, RMA2, RMA3, RN181, RNF103, RNF111, RNF180, RNF186, RNF190, RNF2, RNF20, RNF220, RNF4, RNF43, RNF45, RNF8, salt tolerance RING finger 1, SDIR1, SIRP2, Sis3, SSM4, STIP1 homology and U-Box containing protein 1, Strf1, TEB4, TRIM22, Trim23, TRIM25, TRIM3, TRIM5, TRIM5alpha, TRIM62, TRIM69, tripartite motif-containing protein 5, U-box domain-containing protein 17, Ube4A, UBE4B, ubiquitin ligase E3, ubiquitin ligase Ubr1, ubiquitin-protein ligase K3, UBR1, UFD-2, Xbat32, ZNRF1
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Reference on EC 2.3.2.27 - RING-type E3 ubiquitin transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chin, L.S.; Vavalle, J.P.; Li, L.
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation
J. Biol. Chem.
277
35071-35079
2002
Rattus norvegicus (Q8CJB9)
Vander Kooi, C.W.; Ohi, M.D.; Rosenberg, J.A.; Oldham, M.L.; Newcomer, M.E.; Gould, K.L.; Chazin, W.J.
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases
Biochemistry
45
121-130
2006
Saccharomyces cerevisiae (P32523)
Gack, M.U.; Shin, Y.C.; Joo, C.H.; Urano, T.; Liang, C.; Sun, L.; Takeuchi, O.; Akira, S.; Chen, Z.; Inoue, S.; Jung, J.U.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Nature
446
916-920
2007
Homo sapiens (Q14258)
Yang, C.W.; Gonzalez-Lamothe, R.; Ewan, R.A.; Rowland, O.; Yoshioka, H.; Shenton, M.; Ye, H.; ODonnell, E.; Jones, J.D.; Sadanandom, A.
The E3 ubiquitin ligase activity of Arabidopsis PLANT U-BOX17 and its functional tobacco homolog ACRE276 are required for cell death and defense
Plant Cell
18
1084-1098
2006
Arabidopsis thaliana (Q9C7R6), Arabidopsis thaliana, Nicotiana tabacum (Q84QD7), Nicotiana tabacum, Solanum lycopersicum
Brophy, T.M.; Raab, M.; Daxecker, H.; Culligan, K.G.; Lehmann, I.; Chubb, A.J.; Treumann, A.; Moran, N.
RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3
Biochem. Biophys. Res. Commun.
369
1088-1093
2008
Homo sapiens (Q9P0P0), Homo sapiens
Duan, Z.; Gao, B.; Xu, W.; Xiong, S.
Identification of TRIM22 as a RING finger E3 ubiquitin ligase
Biochem. Biophys. Res. Commun.
374
502-506
2008
Homo sapiens (Q8IYM9)
Maruyama, Y.; Yamada, M.; Takahashi, K.; Yamada, M.
Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway
Biochem. Biophys. Res. Commun.
374
737-741
2008
Rattus norvegicus (Q9EPZ8)
Wiborg, J.; OShea, C.; Skriver, K.
Biochemical function of typical and variant Arabidopsis thaliana U-box E3 ubiquitin-protein ligases
Biochem. J.
413
447-457
2008
Arabidopsis thaliana (Q9LQ92)
Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
BMC Struct. Biol.
8
26
2008
Danio rerio (Q7ZTZ6)
Sugiura, T.; Yamaguchi, A.; Miyamoto, K.
A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95
Exp. Cell Res.
314
1519-1528
2008
Homo sapiens (Q68DV7)
Yamauchi, K.; Wada, K.; Tanji, K.; Tanaka, M.; Kamitani, T.
Ubiquitination of E3 ubiquitin ligase TRIM5alpha and its potential role
FEBS J.
275
1540-1555
2008
Homo sapiens (Q9C035), Homo sapiens
Ogawa, M.; Mizugishi, K.; Ishiguro, A.; Koyabu, Y.; Imai, Y.; Takahashi, R.; Mikoshiba, K.; Aruga, J.
Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase
Genes Cells
13
397-409
2008
Mus musculus (Q3U827)
Tatematsu, K.; Yoshimoto, N.; Okajima, T.; Tanizawa, K.; Kuroda, S.
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta
J. Biol. Chem.
283
11575-11585
2008
Rattus norvegicus (Q62921)
Tatham, M.H.; Geoffroy, M.C.; Shen, L.; Plechanovova, A.; Hattersley, N.; Jaffray, E.G.; Palvimo, J.J.; Hay, R.T.
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Nat. Cell Biol.
10
538-546
2008
Homo sapiens (Q9UNE7)
Lee, J.H.; Terzaghi, W.; Gusmaroli, G.; Charron, J.B.; Yoon, H.J.; Chen, H.; He, Y.J.; Xiong, Y.; Deng, X.W.
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases
Plant Cell
20
152-167
2008
Arabidopsis thaliana (Q8LGH4), Arabidopsis thaliana
Perez-Oliva, A.B.; Olivares, C.; Jimenez-Cervantes, C.; Garcia-Borron, J.C.
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas
J. Biol. Chem.
284
31714-31725
2009
Homo sapiens (O60921), Homo sapiens
Son, O.; Cho, S.K.; Kim, E.Y.; Kim, W.T.
Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase
Plant Cell Rep.
28
561-569
2009
Arabidopsis thaliana (O64425), Arabidopsis thaliana (P93030), Arabidopsis thaliana (Q8GUK7)
Eisele, F.; Wolf, D.H.
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1
FEBS Lett.
582
4143-4146
2008
Saccharomyces cerevisiae
Lee, D.H.; Choi, H.W.; Hwang, B.K.
The pepper E3 ubiquitin ligase RING1 gene, CaRING1, is required for cell death and the salicylic acid-dependent defense response
Plant Physiol.
156
2011-2025
2011
Capsicum annuum (G0T3B3)
Kong, Q.; Zeng, W.; Wu, J.; Hu, W.; Li, C.; Mao, B.
RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination
Biochem. Biophys. Res. Commun.
393
708-713
2010
Mus musculus (Q6PDX6)
Hassink, G.; Kikkert, M.; Van Voorden, S.; Lee, S.; Spaapen, R.; Van Laar, T.; Coleman, C.; Bartee, E.; Früh, K.; Chau, V.; Wiertz, E.
TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum
Biochem. J.
388
647-655
2005
Homo sapiens (O60337)
Kassenbrock, C.; Anderson, S.
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
J. Biol. Chem.
279
28017-28027
2004
Homo sapiens (P22681)
Atipairin, A.; Canyuk, B.; Ratanaphan, A.
Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature
J. Biol. Inorg. Chem.
16
217-226
2011
Homo sapiens
Du, Q.; Cui, W.; Zhang, C.; Yu, D.
GmRFP1 encodes a previously unknown RING-type E3 ubiquitin ligase in soybean (Glycine max)
Mol. Biol. Rep.
37
685-693
2010
Glycine max (C6EUD3), Glycine max
Jung, Y.; Liu, G.; Chen, X.
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
Mol. Cell. Biol.
30
1041-1048
2010
Homo sapiens (Q96PM5), Homo sapiens
Saha, A.; Lewis, S.; Kleiger, G.; Kuhlman, B.; Deshaies, R.J.
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate
Mol. Cell
42
75-83
2011
Homo sapiens
Riley, B.E.; Lougheed, J.C.; Callaway, K.; Velasquez, M.; Brecht, E.; Nguyen, L.; Shaler, T.; Walker, D.; Yang, Y.; Regnstrom, K.; Diep, L.; Zhang, Z.; Chiou, S.; Bova, M.; Artis, D.R.; Yao, N.; Baker, J.; Yednock, T.; Johnston, J.A.
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
Nat. Commun.
4
1982
2013
Homo sapiens (O60260)
Li, W.; Tu, D.; Brunger, A.; Ye, Y.
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
Nature
446
333-337
2007
Homo sapiens (Q9UKV5)
Spratt, D.E.;, Mercier, P.; Shaw, G.S.
Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase
PLoS One
15
e74047
2013
Homo sapiens (Q9Y4X5), Homo sapiens
Han, Y.; Li, R.; Gao, J.; Miao, S.; Wang, L.
Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation
Biochem. Biophys. Res. Commun.
429
6-11
2012
Homo sapiens (Q86WT6), Homo sapiens
Huang, F.; Xiao, H.; Sun, B.L.; Yang, R.G.
Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization
Biochem. Biophys. Res. Commun.
432
208-213
2013
Arabidopsis thaliana (Q8GYT9), Homo sapiens (Q9BVG3)
Raheja, R.; Liu, Y.; Hukkelhoven, E.; Yeh, N.; Koff, A.
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity
Biochem. J.
458
537-545
2014
Mus musculus
Nguyen, L.; Plafker, K.S.; Starnes, A.; Cook, M.; Klevit, R.E.; Plafker, S.M.
The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin
Biochemistry
53
4004-4014
2014
Homo sapiens (Q96BH1)
Wang, P.; Wu, Y.; Li, Y.; Zheng, J.; Tang, J.
A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1
Cell. Signal.
25
2320-2333
2013
Homo sapiens (Q9NXI6), Homo sapiens
Buchwald, G.; van der Stoop, P.; Weichenrieder, O.; Perrakis, A.; van Lohuizen, M.; Sixma, T.K.
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b
EMBO J.
25
2465-2474
2006
Homo sapiens (Q99496)
Lee, S.J.; Choi, J.Y.; Sung, Y.M.; Park, H.; Rhim, H.; Kang, S.
E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme
FEBS Lett.
503
61-64
2001
Homo sapiens (Q99496), Homo sapiens
Dodd, R.; Allen, M.; Brown, S.; Sanderson, C.; Duncan, L.; Lehner, P.; Bycroft, M.; Read, R.
Solution structure of the Kaposis sarcoma-associated herpesvirus K3 N-terminal domain reveals a novel E2-binding C4HC3-type RING domain
J. Biol. Chem.
279
53840-53847
2004
Human gammaherpesvirus 8 (P90495), Human gammaherpesvirus 8 GK18 (P90495)
Iyengar, P.V.; Hirota, T.; Hirose, S.; Nakamura, N.
Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella
J. Biol. Chem.
286
39082-39090
2011
Rattus norvegicus (G3XDV3)
Liu, H.; Stone, S.L.
Cytoplasmic degradation of the Arabidopsis transcription factor abscisic acid insensitive 5 is mediated by the RING-type E3 ligase KEEP ON GOING
J. Biol. Chem.
288
20267-20279
2013
Arabidopsis thaliana (Q9FY48), Arabidopsis thaliana
Wang, Y.; Kim, S.M.; Trnka, M.J.; Liu, Y.; Burlingame, A.L.; Correia, M.A.
Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes
J. Biol. Chem.
290
3308-3332
2015
Homo sapiens (Q9UKV5)
Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
J. Cell Sci.
127
3488-3504
2014
Homo sapiens (O60260)
Lim, S.D.; Cho, H.Y.; Park, Y.C.; Ham, D.J.; Lee, J.K.; Jang, C.S.
The rice RING finger E3 ligase, OsHCI1, drives nuclear export of multiple substrate proteins and its heterogeneous overexpression enhances acquired thermotolerance
J. Exp. Bot.
64
2899-2914
2013
Oryza sativa (Q337S3), Oryza sativa
Fraser, J.; Worrall, E.; Lin, Y.; Landre, V.; Pettersson, S.; Blackburn, E.; Walkinshaw, M.; Muller, P.; Vojtesek, B.; Ball, K.; Hupp, T.
Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis
J. Mol. Biol.
427
1728-1747
2014
Homo sapiens (P51668)
-
Taherbhoy, A.; Huang, O.; Cochran, A.
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
Nat. Commun.
6
7621
2015
Homo sapiens (Q99496)
Plechanovova, A.; Jaffray, E.G.; Tatham, M.H.; Naismith, J.H.; Hay, R.T.
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
Nature
489
115-120
2012
Rattus norvegicus (O88846)
Gao, W.; Liu, W.; Zhao, M.; Li, W.X.
NERF encodes a RING E3 ligase important for drought resistance and enhances the expression of its antisense gene NFYA5 in Arabidopsis
Nucleic Acids Res.
43
607-617
2015
Arabidopsis thaliana (Q9SYH3)
Peng, Y.J.; Shih, C.F.; Yang, J.Y.; Tan, C.M.; Hsu, W.H.; Huang, Y.P.; Liao, P.C.; Yang, C.H.
A RING-type E3 ligase controls anther dehiscence by activating the jasmonate biosynthetic pathway gene DEFECTIVE IN ANTHER DEHISCENCE1 in Arabidopsis
Plant J.
74
310-327
2013
Arabidopsis thaliana
Tian, M.; Lou, L.; Liu, L.; Yu, F.; Zhao, Q.; Zhang, H.; Wu, Y.; Tang, S.; Xia, R.; Zhu, B.; Serino, G.; Xie, Q.
The RING finger E3 ligase STRF1 is involved in membrane trafficking and modulates salt-stress response in Arabidopsis thaliana
Plant J.
82
81-92
2015
Arabidopsis thaliana (Q9LUZ9), Arabidopsis thaliana
Lim, S.D.; Hwang, J.G.; Han, A.R.; Park, Y.C.; Lee, C.; Ok, Y.S.; Jang, C.S.
Positive regulation of rice RING E3 ligase OsHIR1 in arsenic and cadmium uptakes
Plant Mol. Biol.
85
365-379
2014
Oryza sativa (Q01I44), Oryza sativa
Prasad, M.E.; Schofield, A.; Lyzenga, W.; Liu, H.; Stone, S.L.
Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis
Plant Physiol.
153
1587-1596
2010
Arabidopsis thaliana (Q6NLQ8)
Ryu, M.Y.; Cho, S.K.; Kim, W.T.
The Arabidopsis C3H2C3-type RING E3 ubiquitin ligase AtAIRP1 is a positive regulator of an abscisic acid-dependent response to drought stress
Plant Physiol.
154
1983-1997
2010
Arabidopsis thaliana (Q93ZF6)
Li, H.; Jiang, H.; Bu, Q.; Zhao, Q.; Sun, J.; Xie, Q.; Li, C.
The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic acid signaling and drought response
Plant Physiol.
156
550-563
2011
Arabidopsis thaliana (Q9ZU51)
Cho, S.K.; Ryu, M.Y.; Seo, D.H.; Kang, B.G.; Kim, W.T.
The Arabidopsis RING E3 ubiquitin ligase AtAIRP2 plays combinatory roles with AtAIRP1 in abscisic acid-mediated drought stress responses
Plant Physiol.
157
2240-2257
2011
Arabidopsis thaliana
Cheng, M.C.; Hsieh, E.J.; Chen, J.H.; Chen, H.Y.; Lin, T.P.
Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response
Plant Physiol.
158
363-375
2012
Arabidopsis thaliana (Q9LY87)
Kim, J.H.; Kim, W.T.
The Arabidopsis RING E3 ubiquitin ligase AtAIRP3/LOG2 participates in positive regulation of high-salt and drought stress responses
Plant Physiol.
162
1733-1749
2013
Arabidopsis thaliana (Q9S752)
Pauwels, L.; Ritter, A.; Goossens, J.; Nagels Durand, A.; Liu, H.X.; Gu, Y.; Geerinck, J.; Boter, M.; Vanden Bossche, R.; De Clercq, R.; Van Leene, J.; Gevaert, K.; De Jaeger, G.; Solano, R.; Stone, S.L.; Innes, R.W.; Callis, J.; Goossens, A.
The RING E3 ligase KEEP ON GOING modulates JAZ12 stability
Plant Physiol.
169
1405-1417
2015
Arabidopsis thaliana (Q9FY48)
Park, Y.C.; Kim, J.J.; Kim, D.S.; Jang, C.S.
Rice RING E3 ligase may negatively regulate gamma-ray response to mediate the degradation of photosynthesis-related proteins
Planta
241
1119-1129
2015
Oryza sativa
Ho, Y.K.; Zhi, H.; Bowlin, T.; Dorjbal, B.; Philip, S.; Zahoor, M.A.; Shih, H.M.; Semmes, O.J.; Schaefer, B.; Glover, J.N.; Giam, C.Z.
HTLV-1 tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for TAK1 and IKK activation
PLoS Pathog.
11
e1005102
2015
Homo sapiens
Cohen, I.; Wiener, R.; Reiss, Y.; Ravid, T.
Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases
Proc. Natl. Acad. Sci. USA
112
E625-E632
2015
Saccharomyces cerevisiae (P40318), Saccharomyces cerevisiae (Q08109)
Suh, J.Y.; Kim, W.T.
Arabidopsis RING E3 ubiquitin ligase AtATL80 is negatively involved inphosphate mobilization and cold stress response in sufficient phosphate growth conditions
Biochem. Biophys. Res. Commun.
463
793-799
2015
Arabidopsis thaliana (Q9LM69)
Ramadan, A.; Nemoto, K.; Seki, M.; Shinozaki, K.; Takeda, H.; Takahashi, H.; Sawasaki, T.
Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes
BMC Plant Biol.
15
275
2015
Arabidopsis thaliana
Ham, S.J.; Lee, S.Y.; Song, S.; Chung, J.R.; Choi, S.; Chung, J.
Interaction between RING1 (R1) and the ubiquitin-like (UBL) domains is critical for the regulation of parkin activity
J. Biol. Chem.
291
1803-1816
2016
Homo sapiens
Hodge, C.D.; Ismail, I.H.; Edwards, R.A.; Hura, G.L.; Xiao, A.T.; Tainer, J.A.; Hendzel, M.J.; Glover, J.N.
RNF8 E3 ubiquitin ligase stimulates Ubc13 E2 conjugating activity that is essential for DNA double-strand break signaling and BRCA1 tumor suppressor recruitment
J. Biol. Chem.
291
9396-9410
2016
Homo sapiens (O76064)
Yang, L.; Liu, Q.; Liu, Z.; Yang, H.; Wang, J.; Li, X.; Yang, Y.
Arabidopsis C3HC4-RING finger E3 ubiquitin ligase AtAIRP4 positively regulates stress-responsive abscisic acid signaling
J. Integr. Plant Biol.
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67-80
2016
Arabidopsis thaliana
Liu, L.; Jin, L.; Huang, X.; Geng, Y.; Li, F.; Qin, Q.; Wang, R.; Ji, S.; Zhao, S.; Xie, Q.; Wei, C.; Xie, C.; Ding, B.; Li, Y.
OsRFPH2-10, a RING-H2 finger E3 ubiquitin ligase, is involved in rice antiviral defense in the early stages of rice dwarf virus infection
Mol. Plant
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1057-1060
2014
Oryza sativa
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Yu, Y.; Xu, W.; Wang, J.; Wang, L.; Yao, W.; Yang, Y.; Xu, Y.; Ma, F.; Du, Y.; Wang, Y.
The Chinese wild grapevine (Vitis pseudoreticulata) E3 ubiquitin ligase Erysiphe necator-induced RING finger protein 1 (EIRP1) activates plant defense responses by inducing proteolysis of the VpWRKY11 transcription factor
New Phytol.
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Vitis pseudoreticulata
Shin, L.J.; Lo, J.C.; Chen, G.H.; Callis, J.; Fu, H.; Yeh, K.C.
IRT1 degradation factor1, a RING E3 ubiquitin ligase, regulates the degradation of iron-regulated transporter1 in Arabidopsis
Plant Cell
25
3039-3051
2013
Arabidopsis thaliana
Xu, D.; Lin, F.; Jiang, Y.; Huang, X.; Li, J.; Ling, J.; Hettiarachchi, C.; Tellgren-Roth, C.; Holm, M.; Deng, X.W.
The RING-finger E3 ubiquitin ligase COP1 SUPPRESSOR1 negatively regulates COP1 abundance in maintaining COP1 homeostasis in dark-grown Arabidopsis S´seedlings
Plant Cell
26
1981-1991
2014
Arabidopsis thaliana
Zhang, H.; Cui, F.; Wu, Y.; Lou, L.; Liu, L.; Tian, M.; Ning, Y.; Shu, K.; Tang, S.; Xie, Q.
The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING PROTEIN1 for degradation to modulate the salt stress response and ABA signaling in Arabidopsis
Plant Cell
27
214-227
2015
Arabidopsis thaliana
Liu, J.; Zhang, C.; Wei, C.; Liu, X.; Wang, M.; Yu, F.; Xie, Q.; Tu, J.
The RING finger ubiquitin E3 ligase OsHTAS enhances heat tolerance by promoting H2O2-induced stomatal closure in rice
Plant Physiol.
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429-443
2016
Oryza sativa
Jang, K.; Lee, H.G.; Jung, S.J.; Paek, N.C.; Seo, P.J.
The E3 ubiquitin ligase COP1 regulates thermosensory flowering by triggering GI degradation in Arabidopsis
Sci. Rep.
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12071
2015
Arabidopsis thaliana
Duda, D.M.; Olszewski, J.L.; Schuermann, J.P.; Kurinov, I.; Miller, D.J.; Nourse, A.; Alpi, A.F.; Schulman, B.A.
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
Structure
21
1030-1041
2013
Homo sapiens (Q9Y4X5), Homo sapiens
Jiang, J.; Bellani, M.; Li, L.; Wang, P.; Seidman, M.M.; Wang, Y.
Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand crosslink repair
ACS Chem. Biol.
12
1858-1866
2017
Homo sapiens (Q9NW38), Homo sapiens
Lee, S.; Lee, C.; Ryu, K.; Chi, S.
The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2 Crystallization and X-ray diffraction
Acta Crystallogr. Sect. F
76
1-7
2020
Homo sapiens (Q969V5)
Temboot, P.; Lee, R.F.S.; Menin, L.; Patiny, L.; Dyson, P.J.; Ratanaphan, A.
Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity
Biochem. Biophys. Res. Commun.
488
355-361
2017
Homo sapiens (P38398)
Behera, A.P.; Naskar, P.; Agarwal, S.; Banka, P.A.; Poddar, A.; Datta, A.B.
Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications
Biochem. J.
475
1569-1582
2018
Homo sapiens (Q8ND25)
Chasapis, C.T.
Hierarchical core decomposition of RING structure as a method to capture novel functional residues within RING-type E3 ligases a structural systems biology approach
Comput. Biol. Med.
100
86-91
2018
Homo sapiens (P38398), Homo sapiens (Q00987), Homo sapiens (Q13489)
Suisse, A.; Bekes, M.; Huang, T.T.; Treisman, J.E.
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Fly
12
118-126
2018
Mus musculus
Joo, H.; Lim, C.; Han, S.; Lee, S.
The pepper RING finger E3 ligase, CaDIR1, regulates the drought stress response via ABA-mediated signaling
Front. Plant Sci.
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690
2017
Capsicum annuum (A0A2Z2GVU4)
Woodfield, S.E.; Guo, R.J.; Liu, Y.; Major, A.M.; Hollingsworth, E.F.; Indiviglio, S.; Whittle, S.B.; Mo, Q.; Bean, A.J.; Ittmann, M.; Lopez-Terrada, D.; Zage, P.E.
Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B
Genes Cancer
7
13-26
2016
Homo sapiens (O95155), Homo sapiens
Foglizzo, M.; Middleton, A.; Day, C.
Structure and function of the RING domains of RNF20 and RNF40, dimeric E3 ligases that monoubiquitylate Histone H2B
J. Mol. Biol.
428
4073-4086
2016
Homo sapiens (Q5VTR2), Homo sapiens
An, J.; Liu, X.; Song, L.; You, C.; Wang, X.; Hao, Y.
Apple RING finger E3 ubiquitin ligase MdMIEL1 negatively regulates salt and oxidative stresses tolerance
J. Plant Biol.
60
137-145
2017
Malus domestica
Hwang, S.; Park, H.; Han, A.; Jang, C.
Molecular characterization of Oryza sativa arsenic-induced RING E3 ligase 1 (OsAIR1) Expression patterns, localization, functional interaction, and heterogeneous overexpression
J. Plant Physiol.
191
140-148
2016
Oryza sativa Japonica Group
Baranes-Bachar, K.; Levy-Barda, A.; Oehler, J.; Reid, D.A.; Soria-Bretones, I.; Voss, T.C.; Chung, D.; Park, Y.; Liu, C.; Yoon, J.B.; Li, W.; Dellaire, G.; Misteli, T.; Huertas, P.; Rothenberg, E.; Ramadan, K.; Ziv, Y.; Shiloh, Y.
The ubiquitin E3/E4 ligase UBE4A adjusts protein ubiquitylation and accumulation at sites of DNA damage, facilitating double-strand break repair
Mol. Cell
69
866-878.e7
2018
Homo sapiens (Q14139)
Shen, Q.; Hu, T.; Bao, M.; Cao, L.; Zhang, H.; Song, F.; Xie, Q.; Zhou, X.
Tobacco RING E3 ligase NtRFP1 mediates ubiquitination and proteasomal degradation of a geminivirus-encoded betaC1
Mol. Plant
9
911-925
2016
Nicotiana tabacum (R4SB05), Nicotiana tabacum
Ackermann, L.; Schell, M.; Pokrzywa, W.; Kevei, E.; Gartner, A.; Schumacher, B.; Hoppe, T.
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
Nat. Struct. Mol. Biol.
23
995-1002
2016
Caenorhabditis elegans (Q09349), Caenorhabditis elegans
Baek, K.; Krist, D.T.; Prabu, J.R.; Hill, S.; Kluegel, M.; Neumaier, L.M.; von Gronau, S.; Kleiger, G.; Schulman, B.A.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Nature
578
461-466
2020
Homo sapiens (P62877)
Park, J.H.; Kang, C.H.; Nawkar, G.M.; Lee, E.S.; Paeng, S.K.; Chae, H.B.; Chi, Y.H.; Kim, W.Y.; Yun, D.J.; Lee, S.Y.
EMR, a cytosolic-abundant ring finger E3 ligase, mediates ER-associated protein degradation in Arabidopsis
New Phytol.
220
163-177
2018
Arabidopsis thaliana (A0A178UZG1)
Hwang, S.G.; Chapagain, S.; Han, A.R.; Park, Y.C.; Park, H.M.; Kim, Y.H.; Jang, C.S.
Molecular characterization of rice arsenic-induced RING finger E3 ligase 2 (OsAIR2) and its heterogeneous overexpression in Arabidopsis thaliana
Physiol. Plant.
161
372-384
2017
Oryza sativa Japonica Group
Qi, S.; Lin, Q.; Zhu, H.; Gao, F.; Zhang, W.; Hua, X.
The RING finger E3 Ligase SpRing is a positive regulator of salt stress signaling in salt-tolerant wild tomato species
Plant Cell Physiol.
57
528-539
2016
Solanum pimpinellifolium, Solanum pimpinellifolium PI365967
Baek, W.; Lim, C.; Luan, S.; Lee, S.
The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis
Plant J.
100
473-486
2019
Arabidopsis thaliana
Chapagain, S.; Park, Y.; Kim, J.; Jang, C.
Oryza sativa salt-induced RING E3 ligase 2 (OsSIRP2) acts as a positive regulator of transketolase in plant response to salinity and osmotic stress
Planta
247
925-939
2018
Oryza sativa
Jimenez-Lopez, D.; Aguilar-Henonin, L.; Gonzalez-Prieto, J.M.; Aguilar-Hernandez, V.; Guzman, P.
CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes
PLoS ONE
13
e0190969
2018
Arabidopsis thaliana (Q8L649), Homo sapiens (Q6ZNA4)
Li, C.; Wang, J.; Ji, N.; Lei, C.; Zhou, D.; Zheng, Y.; Wang, K.
PpHOS1, a RING E3 ubiquitin ligase, interacts with PpWRKY22 in the BABA-induced priming defense of peach fruit against Rhizopus stolonifer
Postharvest Biol. Technol.
159
111029
2020
Prunus persica
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Ma-Lauer, Y.; Carbajo-Lozoya, J.; Hein, M.; Mueller, M.; Deng, W.; Lei, J.; Meyer, B.; Kusov, Y.; Von Brunn, B.; Bairad, D.; Huenten, S.; Drosten, C.; Hermeking, H.; Leonhardt, H.; Mann, M.; Hilgenfeld, R.; Von Brunn, A.
P53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
Proc. Natl. Acad. Sci. USA
113
E5192-E5201
2016
Homo sapiens (Q96PM5)
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Stewart, M.; Duncan, E.; Coronado, E.; DaRosa, P.; Pruneda, J.; Brzovic, P.; Klevit, R.
Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
Protein Sci.
26
475-483
2017
Homo sapiens (P38398 and Q99728), Homo sapiens
Moududee, S.A.; Jiang, Y.; Gilbert, N.; Xie, G.; Xu, Z.; Wu, J.; Gong, Q.; Tang, Y.; Shi, Y.
Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase
Protein Sci.
27
1661-1669
2018
Homo sapiens (Q5U5Q3), Homo sapiens
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