2.3.2.22: cyclo(L-leucyl-L-leucyl) synthase

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For detailed information about cyclo(L-leucyl-L-leucyl) synthase, go to the full flat file.

Reaction

2 L-leucyl-tRNALeu = 2 tRNALeu +

Synonyms

CDPS, cLL synthase, cyclo(L-leucyl-L-leucyl) synthase, cyclodileucine synthase, cyclodipeptide synthase, pSHaeC06, Shae-CDPS, YvmC

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.22 cyclo(L-leucyl-L-leucyl) synthase

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7	AA Sequence
10	Application
3	Cloned(Commentary)
2	Crystallization (Commentary)
34	General Information
10	Natural Substrates/ Products (Substrates)
22	Organism
1	Pathway
6	PDB ID
2	Purification (Commentary)
3	Reaction
20	Reference
23	Substrates and Products (Substrate)
76	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.2.22 - cyclo(L-leucyl-L-leucyl) synthase

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SYSTEMATIC NAME

IUBMB Comments

L-leucyl-tRNALeu:L-leucyl-tRNALeu leucyltransferase (cyclizing)

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1].