2.3.2.22: cyclo(L-leucyl-L-leucyl) synthase

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For detailed information about cyclo(L-leucyl-L-leucyl) synthase, go to the full flat file.

Reaction

2 L-leucyl-tRNALeu = 2 tRNALeu +

Synonyms

CDPS, cLL synthase, cyclo(L-leucyl-L-leucyl) synthase, cyclodileucine synthase, cyclodipeptide synthase, pSHaeC06, Shae-CDPS, YvmC

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.22 cyclo(L-leucyl-L-leucyl) synthase

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Results	in table
7	AA Sequence
10	Application
3	Cloned(Commentary)
2	Crystallization (Commentary)
34	General Information
10	Natural Substrates/ Products (Substrates)
22	Organism
1	Pathway
6	PDB ID
2	Purification (Commentary)
3	Reaction
20	Reference
23	Substrates and Products (Substrate)
76	Synonyms
1	Systematic Name

Crystallization

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Crystallization on EC 2.3.2.22 - cyclo(L-leucyl-L-leucyl) synthase

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in the apo form and complexed with substrate mimics, at 1.7-2.4 A resolutions. Data show the presence of an aminoacyl-enzyme reaction intermediate, but not a dipeptide tRNA intermediate. Reaction follows a sequential catalytic mechanism, with the successive attachment of two leucine residues on the enzyme via a conserved serine residue

Bacillus licheniformis

Q65EX3

723646

purified recombinant enzyme, crystallization from 30% PEG 4000, 0.1 M Tris-HCl, pH 8.5, and 0.2 M lithium sulfate monohydrate, X-ray diffraction structure determination and analysis at 2.99 A resolution

Staphylococcus haemolyticus

Q4L2X9

759679