2.3.2.21: cyclo(L-tyrosyl-L-tyrosyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-tyrosyl-L-tyrosyl) synthase, go to the full flat file.

Reaction

2 L-tyrosyl-tRNATyr = 2 tRNATyr +

Synonyms

CDPS, CDPS-Np, cyclo(L-tyrosyl-L-tyrosyl) synthase, cyclodipeptide synthase, cyclodityrosine synthetase, cYY synthase, Rv2275

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.21 cyclo(L-tyrosyl-L-tyrosyl) synthase

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Results	in table
2	AA Sequence
3	Application
2	Cloned(Commentary)
1	Crystallization (Commentary)
11	General Information
4	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
8	Protein Variants
2	Purification (Commentary)
3	Reaction
8	Reference
12	Substrates and Products (Substrate)
25	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Reference

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Reference on EC 2.3.2.21 - cyclo(L-tyrosyl-L-tyrosyl) synthase

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723244

Gondry, M.; Sauguet, L.; Belin, P.; Thai, R.; Amouroux, R.; Tellier, C.; Tuphile, K.; Jacquet, M.; Braud, S.; Courcon, M.; Masson, C.; Dubois, S.; Lautru, S.; Lecoq, A.; Hashimoto, S.; Genet, R.; Pernodet, J.L.

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes

Nat. Chem. Biol.

414-420

2009

Mycobacterium tuberculosis

19430487

723247

Vetting, M.W.; Hegde, S.S.; Blanchard, J.S.

The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase

Nat. Chem. Biol.

797-799

2010

Mycobacterium tuberculosis (P9WPF9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPF9)

20852636

759643

Brockmeyer, K.; Li, S.M.

Mutations of residues in pocket P1 of a cyclodipeptide synthase strongly increase product formation

J. Nat. Prod.

2917-2922

2017

Nocardiopsis prasina

29064250

759679

Bourgeois, G.; Seguin, J.; Babin, M.; Belin, P.; Moutiez, M.; Mechulam, Y.; Gondry, M.; Schmitt, E.

Structural basis for partition of the cyclodipeptide synthases into two subfamilies

J. Struct. Biol.

203

17-26

2018

Mycobacterium tuberculosis (P9WPF9), Mycobacterium tuberculosis H37Rv (P9WPF9), Mycobacterium tuberculosis ATCC 25618 (P9WPF9)

29505829

759890

Borgman, P.; Lopez, R.; Lane, A.

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Org. Biomol. Chem.

2305-2314

2019

Mycobacterium tuberculosis (P9WPF9)

30688950