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2.3.2.2: gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about gamma-glutamyltransferase, go to the full flat file.

Word Map on EC 2.3.2.2

Reaction

a (5-L-glutamyl)-peptide
+
an amino acid
=
a peptide
 +
a 5-L-glutamyl amino acid

Synonyms

(5-L-glutamyl) peptide: amino-acid 5-glutamyl transferase, alpha-glutamyl transpeptidase, AngammaGT, AsGGT1, At1g69820, At4g29210, At4g39640, At4g39650, BaGGT, BaGGT42, BaGGT469, BlGGT, BlGGT13, BsGGT168, Cgl0954, eqGGT, gamma glutamyl transferase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transferase, gamma-glutamyl transferase 1, gamma-glutamyl transferase 5, gamma-glutamyl transferase/transpeptidase, gamma-glutamyl transferases, gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidase 1, gamma-glutamyl transpeptidase 4, gamma-glutamyl transpeptidase-1, gamma-glutamyl-transpeptidase, gamma-glutamyltransferase, gamma-glutamyltranspeptidase, gamma-GPT, gamma-GT, gamma-GTase, gamma-GTP, gammaGT, GGT, GGT A, GGT I, GGT-1, GGT1, GGT2, GGT3, GGT4, GGT5, ggtB, GGTII protein, GGTLA1, glutamyl transpeptidase, glutamyltransferase, gamma-, HGGT, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase, More, PnGGT, SBLGGT, VvGGT3

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.2 gamma-glutamyltransferase

pH Range

pH Range on EC 2.3.2.2 - gamma-glutamyltransferase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 10
-
optimum activity at pH 7.0, 80% of maximal activity at pH 6.5-8.0, and residual activity sharply decreased to less than 50% at above pH 10.0 or below pH 4.0
3 - 11
active at, inactive below, profile overview
4 - 10
BaGGT469 shows the highest activity towards L-gamma-glutamyl-4-nitroanilide with diglycine acceptor in 50 mM borate-NaOH buffer at pH 10.0. The enzymatic activity at the alkaline pH range of pH 8.0-9.0 is 92.6-95.9% relative to that at optimum pH. BaGGT469 is much less active in the acidic pH range from pH 4.0-6.0
4 - 11
4 - 13
pH 4.0: about 50% of maximal activity, pH 13: about 40% of maximal activity
4 - 9
more than 40% of maximal activity, hydrolysis of gamma-glutamyl-4-nitroanilide
5 - 11
5 - 12
5.5 - 12
activity range, over 60% of maximal activity at pH 7.5-10.5, profile overview
6 - 11
-
50% of maximal activity within this range, recombinant wild-type free enzyme, over 80% of maximal activity within this range, recombinant wild-type immobilized enzyme modified MTWs-GGT-Phar, the activity of recombinant immobilized enzyme MTWs-GGT is abolished above pH 10.0
6 - 9
6.5 - 9
-
pH 6.5: about 50% of maximal activity, pH 9.0: about 90% of maximal activity
6.5 - 9.5
-
about half-maximal activity at pH 6.5 and 9.5
7 - 10
-
no significant activities are detected below pH 7.0 or above pH 10.0
7 - 11
7 - 9
7.3 - 8.5
-
about half-maximal activity at pH 7.3, maximal activity at pH 8.5
7.5 - 10
-
pH 7.5: about 40% of maximal activity, pH 10.0: about 35% of maximal activity, glutaminase activity of mutant enzyme D445A
7.5 - 9
-
about half-maximal activity at pH 7.5, about 90% of maximal activity at pH 9.0
8 - 11
8.1 - 9.6
-
about 70% of maximal activity at pH 8.1, about 75% of maximal activity at pH 9.6