2.3.2.2: gamma-glutamyltransferase
This is an abbreviated version!
For detailed information about gamma-glutamyltransferase, go to the full flat file.
Word Map on EC 2.3.2.2
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2.3.2.2
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aminotransferase
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alt
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bilirubin
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cholesterol
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albumin
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triglyceride
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bile
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biliary
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women
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creatinine
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gsh
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transaminase
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hepatocytes
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cirrhosis
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fibrosis
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urinary
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cholestasis
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duct
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uric
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c-reactive
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steatosis
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aminopeptidase
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jaundice
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drinkers
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hepatotoxicity
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non-alcoholic
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intrahepatic
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nafld
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nephrotoxicity
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ursodeoxycholic
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waist
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ultrasonography
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diethylnitrosamine
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circumference
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corpuscular
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hepatocarcinogenesis
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abuse
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hepatectomy
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hepatobiliary
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phenobarbital
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preneoplastic
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alpha-fetoprotein
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homa-ir
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abstinence
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pruritus
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2-acetylaminofluorene
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n-acetyl-beta-d-glucosaminidase
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cholangitis
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cholangiopancreatography
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pharmacology
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elastography
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diagnostics
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nutrition
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food industry
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drug development
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analysis
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medicine
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synthesis
- 2.3.2.2
- aminotransferase
-
alt
- bilirubin
- cholesterol
- albumin
- triglyceride
- bile
- biliary
- women
- creatinine
- gsh
- transaminase
- hepatocytes
- cirrhosis
- fibrosis
- urinary
- cholestasis
- duct
-
uric
-
c-reactive
- steatosis
- aminopeptidase
- jaundice
-
drinkers
-
hepatotoxicity
-
non-alcoholic
-
intrahepatic
- nafld
-
nephrotoxicity
-
ursodeoxycholic
-
waist
-
ultrasonography
- diethylnitrosamine
-
circumference
-
corpuscular
-
hepatocarcinogenesis
-
abuse
-
hepatectomy
- hepatobiliary
- phenobarbital
-
preneoplastic
- alpha-fetoprotein
-
homa-ir
-
abstinence
- pruritus
- 2-acetylaminofluorene
-
n-acetyl-beta-d-glucosaminidase
- cholangitis
-
cholangiopancreatography
- pharmacology
-
elastography
- diagnostics
- nutrition
- food industry
- drug development
- analysis
- medicine
- synthesis
Reaction
Synonyms
(5-L-glutamyl) peptide: amino-acid 5-glutamyl transferase, alpha-glutamyl transpeptidase, AngammaGT, AsGGT1, At1g69820, At4g29210, At4g39640, At4g39650, BaGGT, BaGGT42, BaGGT469, BlGGT, BlGGT13, BsGGT168, Cgl0954, eqGGT, gamma glutamyl transferase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transferase, gamma-glutamyl transferase 1, gamma-glutamyl transferase 5, gamma-glutamyl transferase/transpeptidase, gamma-glutamyl transferases, gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidase 1, gamma-glutamyl transpeptidase 4, gamma-glutamyl transpeptidase-1, gamma-glutamyl-transpeptidase, gamma-glutamyltransferase, gamma-glutamyltranspeptidase, gamma-GPT, gamma-GT, gamma-GTase, gamma-GTP, gammaGT, GGT, GGT A, GGT I, GGT-1, GGT1, GGT2, GGT3, GGT4, GGT5, ggtB, GGTII protein, GGTLA1, glutamyl transpeptidase, glutamyltransferase, gamma-, HGGT, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase, More, PnGGT, SBLGGT, VvGGT3
ECTree
2.3.2.2 gamma-glutamyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.3.2.2 - gamma-glutamyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0334
5-L-glutamyl-L-leucine
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0346
glutathione sulfonic acid
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0751
glutathionesulfonic acid
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0109
5-L-glutamyl-4-nitroanilide
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37°C, pH 8.0, transpeptidase reaction with Gly-Gly
0.024
5-L-glutamyl-4-nitroanilide
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37°C, pH 8.0, cosubstrate: Gly-Gly, enzyme form GGT II
0.046
5-L-glutamyl-4-nitroanilide
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37°C, pH 8.0, cosubstrate: Gly-Gly, enzyme form GGT I
0.08
5-L-glutamyl-4-nitroanilide
in 1 mM MgCl2, 50 mM Tris-HCl buffer (pH 8.0), at 40°C
0.22
5-L-glutamyl-4-nitroanilide
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monomeric 30-kDa enzyme, at pH 11.0, in the presence of subtilisin, at 80°C
0.25
5-L-glutamyl-4-nitroanilide
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heterodimeric 67-kDa enzyme, at pH 8.0, in the absence of subtilisin, at 60°C
0.84
5-L-glutamyl-4-nitroanilide
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reaction in the presence of 20 mM glycylglycine
4.3
5-L-glutamyl-4-nitroanilide
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37°C, pH 8.0, cosubstrate: Gly-Gly, enzyme form GGT B
4.4
5-L-glutamyl-4-nitroanilide
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37°C, pH 8.0, cosubstrate: Gly-Gly, enzyme form GGT A
5.2
5-L-glutamyl-4-nitroanilide
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monomeric 30-kDa enzyme, at pH 8.0, in the absence of subtilisin, at 60°C
0.038
gamma-Glu-Cys
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37°C, pH 8.0, cosubstrate: Gly-Gly, enzyme form GGT II
0.0143
gamma-L-glutamyl-4-nitroanilide
pH 7.0, temperature not specified in the publication, hydrolytic activity, mutant enzyme H368S
0.025
gamma-L-glutamyl-4-nitroanilide
pH 7.0, temperature not specified in the publication, transpeptidase activity with Gly-Gly as acceptor, mutant enzyme H368S
0.025
gamma-L-glutamyl-4-nitroanilide
pH 7.0, temperature not specified in the publication, transpeptidase activity with Gly-Gly as acceptor, mutant enzyme Y327N
0.067
gamma-L-glutamyl-4-nitroanilide
pH 7.0, temperature not specified in the publication, hydrolytic activity, mutant enzyme Y327N
0.1
gamma-L-glutamyl-4-nitroanilide
pH 7.0, temperature not specified in the publication, hydrolytic activity, wild-type enzyme
0.0105
GSH
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0106
GSH
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.008
GSSG
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0426
GSSG
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.123
L-gamma-glutamyl-4-nitroanilide
pH 9.6, 37°C, recombinant enzyme
0.2
L-gamma-glutamyl-4-nitroanilide
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pH 8.0, 37°C, native extracellular enzyme
0.214
L-gamma-glutamyl-4-nitroanilide
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recombinant extracellular enzyme, pH 9.0, 40°C
0.3
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109F, pH 9.0, 60°C
0.4
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109E, pH 9.0, 60°C
0.4
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109S, pH 9.0, 60°C
0.4
L-gamma-glutamyl-4-nitroanilide
recombinant wild-type enzyme, pH 9.0, 60°C
0.42
L-gamma-glutamyl-4-nitroanilide
Q62WE3
recombinant wild-type enzyme, pH 9.0, 40°C
0.579
L-gamma-glutamyl-4-nitroanilide
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recombinant immobilized modified wild-type enzyme MTWs-GGT-Phar, pH 8.0, 37°C
0.58
L-gamma-glutamyl-4-nitroanilide
Q62WE3
recombinant mutant N450D, pH 9.0, 40°C
0.58
L-gamma-glutamyl-4-nitroanilide
Q62WE3
recombinant mutant N450Q, pH 9.0, 40°C
0.597
L-gamma-glutamyl-4-nitroanilide
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recombinant free wild-type enzyme GGT, pH 8.0, 37°C
0.69
L-gamma-glutamyl-4-nitroanilide
Q62WE3
recombinant mutant N450A, pH 9.0, 40°C
0.7
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109K, pH 9.0, 60°C
0.76
L-gamma-glutamyl-4-nitroanilide
Q62WE3
recombinant mutant N450K, pH 9.0, 40°C
0.879
L-gamma-glutamyl-4-nitroanilide
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recombinant immobilized wild-type enzyme, MTWs-GGT, pH 8.0, 37°C
8.2
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109L, pH 9.0, 60°C
10.6
L-gamma-glutamyl-4-nitroanilide
recombinant mutant R109M, pH 9.0, 60°C
0.13 - 0.18
L-Glu-4-nitroanilide
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with L-Cys-bis-glycine, rat kidney enzyme
0.0102
leukotriene C4
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0108
leukotriene C4
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0131
S-(4-nitro-benzyl)glutathione
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0148
S-(4-nitro-benzyl)glutathione
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0099
S-Methylglutathione
isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0182
S-Methylglutathione
isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
additional information
additional information
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Km-values for several acceptors in diabetic and control rats, female and male, with donors L-Glu-4-nitroanilide and L-5-glutamyl-(7-amido-4-methylcoumarin)
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additional information
additional information
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Km values for several amino acids and dipeptides, overview
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additional information
additional information
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Km values for several amino acids and dipeptides, overview
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additional information
additional information
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Km values for several amino acids and dipeptides, overview
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additional information
additional information
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kinetic study of renatured large subunit
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additional information
additional information
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enzyme from seminal plasma, kidney, prostate, and testis
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additional information
additional information
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biphasic kinetics in transpeptidase reaction with 1-aminocyclopropane-1-carboxylic acid as acceptor, Km-values
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additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
enzyme kinetics analysis is done according to the ping-pong mechanism when both the substrates L-gamma-glutamyl-4-nitroanilide and glycyl-glycine are used
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additional information
additional information
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enzyme kinetics analysis is done according to the ping-pong mechanism when both the substrates L-gamma-glutamyl-4-nitroanilide and glycyl-glycine are used
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additional information
additional information
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Michaelis-Menten kinetics with L-gamma-glutamyl-4-nitroanilide as substrate, native extracellular enzyme
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additional information
additional information
steady-state kinetics of purified free enzyme BLGGT and purified immobilized enzyme CMS-GGT
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additional information
additional information
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thermodynamics and kinetic analysis of free and immobilized recombinant enzymes, overview
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