2.3.2.18: N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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Reaction
+ 2 glycyl-tRNAGly = + 2 tRNAGly
Synonyms
FemABX peptidyl transferase, FemB
ECTree
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Engineering
Engineering on EC 2.3.2.18 - N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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additional information
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in strains carrying mutations of FemA, femAB, or the femAX genes, the sorting reaction of surface proteins is significantly slowed. Strains carrying mutations in the fem genes display a decreased rate of surface protein precursor cleavage as compared with the wildtype strains, suggesting that the altered cross-bridges slow the anchoring of surface proteins
additional information
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the lysostaphin immunity factor Lif is able to complement lack of FemB by inserting serine for glycine in the side chain. Methicillin resistance, which depends on functional FemA and FemB, is not complemented by Lif suggesting that serine-substituted side-chains are a lesser substrate for penicillin-binding protein PBP2' in methicillin resistance