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2.3.2.11: alanylphosphatidylglycerol synthase

This is an abbreviated version!
For detailed information about alanylphosphatidylglycerol synthase, go to the full flat file.

Word Map on EC 2.3.2.11

Reaction

L-alanyl-tRNAAla
+
phosphatidylglycerol
=
tRNAAla
+
3-O-L-alanyl-1-O-phosphatidylglycerol

Synonyms

A-PG synthase, A-PGS, Ala-PG synthase, alanyl phosphatidylglycerol synthetase, alanyl-phosphatidylglycerol synthase, alanylphosphatidylglycerol synthase, Cg1103 protein, MprF1, O-alanylphosphatidylglycerol synthase, synthase, O-alanylphosphatidylglycerol

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.11 alanylphosphatidylglycerol synthase

Engineering

Engineering on EC 2.3.2.11 - alanylphosphatidylglycerol synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D579A
-
the mutant shows decreased activity (3%) compared to the wild type enzyme
D579N
-
the mutant shows decreased activity (5%) compared to the wild type enzyme
D710A
-
the mutant has 26% of wild type activity
D710N
-
the mutant has 30% of wild type activity
D765A
-
inactive
D765N
-
inactive
E657D
-
the mutant shows decreased activity (4%) compared to the wild type enzyme
E657Q
-
the mutant has 21% of wild type activity
E658D
-
the mutant has 28% of wild type activity
E658Q
-
the mutant has 19% of wild type activity
E720Q
-
the mutant has 10% of wild type activity
K580Q
-
inactive
K580S
-
inactive
K654Q
-
the mutant has 65% of wild type activity
K654S
-
the mutant has 46% of wild type activity
K840Q
-
inactive
K840S
-
inactive
K842Q
-
the mutant has wild type activity
K842S
-
the mutant has 50% of wild type activity
M778A
-
the mutant has 50% of wild type activity
R768Q
-
inactive
R768S
-
inactive
R837Q
-
the mutant has wild type activity
R837S
-
the mutant has 65% of wild type activity
S709A
-
the mutant has 5% of wild type activity
S709N
-
the mutant has 17% of wild type activity
S724A
-
the mutant shows decreased activity (7%) compared to the wild type enzyme
S724N
-
inactive
S763A
-
the mutant has 23% of wild type activity
S763N
-
the mutant has 11% of wild type activity
Y635A
-
inactive
Y732A
-
the mutant shows decreased activity (3%) compared to the wild type enzyme
Y831A
-
inactive