2.3.2.10: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

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For detailed information about UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase, go to the full flat file.

Reaction

Synonyms

alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase, alanyltransferase, alanyltransferase, uridine diphosphoacetylmuramoylpentapeptide lysine N6-, FemX, FemXWv, FemXWv transferase, UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase, uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.10 UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

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Results	in table
87	AA Sequence
3	Application
1	CAS Registry Number
3	Cloned(Commentary)
2	Crystallization (Commentary)
5	IC50 Value
8	Inhibitors
3	Ki Value [mM]
9	KM Value [mM]
1	Localization
1	Metals/Ions
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
8	Organism
2	Pathway
10	PDB ID
5	pH Optimum
4	pH Range
18	Protein Variants
5	Purification (Commentary)
3	Reaction
3	Reaction Type
8	Reference
4	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
1	Subunits
11	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.2.10 - UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Weissella viridescens

-

-

736928

-

-

?

L-alanyl-tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

4 entries

additional information

?

-

2 entries

L-alanyl-tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Weissella viridescens

-

involved in peptidoglucan metabolism, responsible for interpeptide bridges

487792

-

-

ir

L-alanyl-tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Weissella viridescens

-

production of precursors for branched chain peptidoglycans

659068

-

-

?

L-alanyl-tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Weissella viridescens

Q9EY50

production of precursors for branched chain peptidoglycans, involved in the synthesis of bacterial cell walls

660520

-

-

?

L-alanyl-tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

tRNAAla + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Weissella viridescens CIP 102810 / ATCC 12706

-

production of precursors for branched chain peptidoglycans

659068

-

-

?

additional information

?

-

Weissella viridescens

-

catalyses the transfer of L-Ala from Ala-tRNAAla to the peptidoglycan precursor UDP-MurNAc-pentapeptide in order to introduce the first residue of an L-Ala-L-Ser-L-Ala side chain

703214

-

-

?

additional information

?

-

Weissella viridescens

-

FemXWv transferase adds the first residue of the L-Ala-L-Ser-L-Ala side chain onto the nucleotide precursor UDP-MurNAc-pentadepsipeptide

705965

-

-

?