2.3.1.B40: caliceamicin octaketide synthase
This is an abbreviated version!
For detailed information about caliceamicin octaketide synthase, go to the full flat file.
Word Map on EC 2.3.1.B40
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2.3.1.B40
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polyketide
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enediyne
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calicheamicins
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thioesterase
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iterative
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polyene
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echinospora
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micromonospora
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10-membered
- 2.3.1.B40
- polyketide
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enediyne
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calicheamicins
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thioesterase
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iterative
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polyene
- echinospora
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micromonospora
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10-membered
Reaction
8 malonyl-CoA + + = 8 CoA + + 8 CO2 + +
Synonyms
CalE8, enediyne polyketide synthase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.3.1.B40 - caliceamicin octaketide synthase
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REACTION DIAGRAM
8 malonyl-CoA + NADPH + H+
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2
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the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin
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additional information
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a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction
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