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2.3.1.B40: caliceamicin octaketide synthase

This is an abbreviated version!
For detailed information about caliceamicin octaketide synthase, go to the full flat file.

Word Map on EC 2.3.1.B40

Reaction

8 malonyl-CoA +

NADPH
+
H+
= 8 CoA +
(4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid
+ 8 CO2 +
NADP+
+
H2O

Synonyms

CalE8, enediyne polyketide synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B40 caliceamicin octaketide synthase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.B40 - caliceamicin octaketide synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
8 malonyl-CoA + NADPH + H+
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2
show the reaction diagram
-
the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin
-
?
additional information
?
-
a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction
-
-
?