2.3.1.B38: heptylquinolone synthase

This is an abbreviated version!
For detailed information about heptylquinolone synthase, go to the full flat file.

Word Map on EC 2.3.1.B38

2.3.1.B38

aeruginosa

opportunistic

condensing

n-oxides

2-heptyl-3-hydroxy-41h-quinolone

heterodimeric

Reaction

Synonyms

2-heptyl-4(1H)-quinolone synthase, PqsB, PqsBC, PqsC

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.B38 heptylquinolone synthase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
18	General Information
5	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
10	Natural Substrates/ Products (Substrates)
11	Organism
10	Protein Variants
1	Reaction
11	Reference
10	Substrates and Products (Substrate)
37	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.3.1.B38 - heptylquinolone synthase

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octanoyl-CoA + (2-aminobenzoyl)acetate

2-heptyl-4-quinolone + CoA + CO2 + H2O

8 entries

octanoyl-CoA + 2-aminobenzoylacetate

CoA + 2-heptylquinolin-4(1H)-one + CO2 + H2O

Pseudomonas aeruginosa

Q9I4X1

736509

product is a signal molecule in Pseudomonas aeruginosa. The initial product is 1-(2-aminophenyl)decane-1,3-dione which spontaneously rearranges to the product under the elimination of water

additional information

Pseudomonas aeruginosa

Q9I4X1

the catalytic His269 residue is not involved in acyl-enzyme formation, but contributes to an acylation-dependent increase in affinity for the second substrate 2-aminobenzoylacetate. Octanoylation of Cys129 of PqsC is independent of His269

736509