2.3.1.B34: [protein]-L-lysine N-acetyltransferase
This is an abbreviated version!
For detailed information about [protein]-L-lysine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.B34
-
2.3.1.B34
-
deacetylase
-
deacetylation
-
typhimurium
-
gcn5-related
-
nad+-dependent
-
archaeon
-
mycobacteria
-
synthetases
-
hild
-
histone
-
sulfolobus
-
enterica
-
camp
-
tuberculosis
-
serovar
-
smegmatis
- 2.3.1.B34
- deacetylase
-
deacetylation
- typhimurium
-
gcn5-related
-
nad+-dependent
- archaeon
- mycobacteria
- synthetases
- hild
- histone
-
sulfolobus
-
enterica
- camp
- tuberculosis
-
serovar
- smegmatis
Reaction
Synonyms
acetoin utilization protein, acetyltransferase Pat, AcuA, ArtC, BsAcuA, epsilonN-lysine acetyltransferase, GCN5-related N-acetyltransferase, KAT, Micau_1670, MSMEG_5458, Mxan_3215, Pat, PatA, peptidyl-lysine N-acetyltransferase, protein acetyltransferase, Rv0998, SaAcuA, SACE_5148, SePat, SSPG_01886, type-I bGNAT, type-IV bGNAT, YhiQ
ECTree
2.3.1.B34 [protein]-L-lysine N-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.B34 - [protein]-L-lysine N-acetyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + [acetyl coenzyme A synthase Mxan_2570]-L-lysine622
CoA + N-acetyl-[acetyl coenzyme A synthase Mxan_2570]-L-lysine622
-
-
-
?
acetyl-CoA + [BtyA]-L-Lys
CoA + [BtyA]-N6-acetyl-L-Lys
-
substrate is a AMP-forming acyl-CoA synthase, acetylation occurs at the catalytic lysine residue
-
-
?
acetyl-CoA + [DcaA]-L-Lys
CoA + [DcaA]-N6-acetyl-L-Lys
-
substrate is a AMP-forming acyl-CoA synthase, acetylation occurs at the catalytic lysine residue
-
-
?
acetyl-CoA + [DcaB]-L-Lys
CoA + [DcaB]-N6-acetyl-L-Lys
-
substrate is a AMP-forming acyl-CoA synthase, acetylation occurs at the catalytic lysine residue
-
-
?
acetyl-CoA + [DcaC]-L-Lys
CoA + [DcaC]-N6-acetyl-L-Lys
-
substrate is a AMP-forming acyl-CoA synthase, acetylation occurs at the catalytic lysine residue
-
-
?
acetyl-CoA + [GapA]-L-Lys
CoA + [GapA]-N6-acetyl-L-Lys
ACS is glyceraldehyde-3-phosphate dehydrogenase
-
-
?
acetyl-CoA + [LcsB mutant L500V]-L-Lys
CoA + [LcsB mutant L500V]-N6-acetyl-L-Lys
-
wild-type AMP-forming acyl-CoA synthase LcsB is not a substrate, acetylation of mutant L500V occurs at the catalytic lysine residue
-
-
?
acetyl-CoA + [PimA]-L-Lys534
CoA + [PimA]-N6-acetyl-L-Lys534
-
substrate is a AMP-forming acyl-CoA synthase
alanine substitutions at residues Pro528, Arg529, Thr530, Val532, and Gly533 of PimA result in variants that are acetylated less than 50% relative to the wild-type protein. C-terminal to the acetylation site, alanine substitutions at residues Arg537, Leu540, and Arg541 yield variants that also showed less than 50% of wild-type acetylation
-
?
acetyl-CoA + [VcsA]-L-Lys
CoA + [VcsA]-N6-acetyl-L-Lys
-
substrate is a AMP-forming acyl-CoA synthase, acetylation occurs at the catalytic lysine residue
-
-
?
propionyl-CoA + [PprE]-L-Lys
CoA + [PprE]-N6-propionyl-L-Lys
PprE is propionyl-CoA synthetase
-
-
?
acetyl-CoA + [AacS]-L-Lys617
CoA + [AacS]-Nepsilon-acetyl-L-Lys617
-
substrate acetoacetyl-CoA synthase AACS. Acetylation occurs at active site residue Lys617
-
-
?
acetyl-CoA + [AacS]-L-Lys617
CoA + [AacS]-Nepsilon-acetyl-L-Lys617
-
substrate acetoacetyl-CoA synthase AACS. Acetylation occurs at active site residue Lys617
-
-
?
acetyl-CoA + [AceA]-L-Lys
CoA + [AceA]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [AceA]-L-Lys
CoA + [AceA]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [AceA]-L-Lys
CoA + [AceA]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [AceK]-L-Lys
CoA + [AceK]-N6-acetyl-L-Lys
ACS is isocitrate dehydrogenase kinase
-
-
?
acetyl-CoA + [AceK]-L-Lys
CoA + [AceK]-N6-acetyl-L-Lys
ACS is isocitrate dehydrogenase kinase
-
-
?
acetyl-CoA + [AceK]-L-Lys
CoA + [AceK]-N6-acetyl-L-Lys
ACS is isocitrate dehydrogenase kinase
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
enzyme is responsible for the acetylation of the AMP-forming acetyl coenzyme A synthase AcsA, i.e.SACE_2375. Acetylation occurs at residues Lys237, Lys380, Lys611, and Lys628
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
enzyme is responsible for the acetylation of the AMP-forming acetyl coenzyme A synthase AcsA, i.e.SACE_2375. Acetylation occurs at residues Lys237, Lys380, Lys611, and Lys628
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
AcsA is the AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs)
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs), lysine residue K546 is acetylated
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
AcsA is the AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs)
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-acetyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs), lysine residue K546 is acetylated
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [SaAcsA]-N6-acetyl-L-Lys
SaAcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus, lysine residue K546 is acetylated
-
-
?
acetyl-CoA + [AcsA]-L-Lys
CoA + [SaAcsA]-N6-acetyl-L-Lys
SaAcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus, lysine residue K546 is acetylated
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
-
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
r
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is AcCoA synthase, Nepsilon-lysine-acetylation
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is isocitrate lyase
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is AcCoA synthase, Nepsilon-lysine-acetylation
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
ACS is AcCoA synthase, Nepsilon-lysine-acetylation
-
-
?
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
-
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
r
acetyl-CoA + [ACS]-L-Lys
CoA + [ACS]-N6-acetyl-L-Lys
-
ACS is Nepsilon-lysine-acetylated AcCoA synthase
-
-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis
-
-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis
-
-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis(BsAcsA)
-
-
?
acetyl-CoA + [BsAcsA]-L-Lys
CoA + [BsAcsA]-N6-acetyl-L-Lys
BsAcsA is the AMP-forming acetyl-CoA synthetase from Bacillus subtilis(BsAcsA)
-
-
?
acetyl-CoA + [Micau_0428]-L-Lys619
CoA + [Micau_0428]-N6-acetyl-L-Lys619
substrate is acetyl-CoA synthase Micau_0428. substrate mutant K619 is not acetylated
-
-
?
acetyl-CoA + [Micau_0428]-L-Lys619
CoA + [Micau_0428]-N6-acetyl-L-Lys619
substrate is acetyl-CoA synthase Micau_0428. substrate mutant K619 is not acetylated
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is AMP-forming acetyl-CoA synthetase from Salmonella enterica
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is AMP-forming acetyl-CoA synthetase from Salmonella enterica
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is the AMP-forming acetyl-CoA synthetase from Salmonella enterica (SeAcs)
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is the AMP-forming acetyl-CoA synthetase from Salmonella enterica (SeAcs)
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is the AMP-forming acetyl-CoA synthetase from Salmonella enterica (SeAcs)
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is the AMP-forming acetyl-CoA synthetase from Salmonella enterica (SeAcs)
-
-
?
acetyl-CoA + [SeAcs]-L-Lys
CoA + [SeAcs]-N6-acetyl-L-Lys
SeAcs is the AMP-forming acetyl-CoA synthetase from Salmonella enterica (SeAcs)
-
-
?
propionyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-propionyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs)
-
-
?
propionyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-propionyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs), lysine residue K546 is propionylated
-
-
?
succinyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-succinyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs). AcuA is the first documented case of a bacterial GNAT capable of succinylation
-
-
?
succinyl-CoA + [AcsA]-L-Lys
CoA + [AcsA]-N6-succinyl-L-Lys
AcsA is AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs). AcuA is the first documented case of a bacterial GNAT capable of succinylation, lysine residue K546 is succinylated
-
-
?
additional information
?
-
enzyme BsAcuA acetylates BsAcsA and also SaAcsA from Staphylococcus aureus, as well as SeAcs from Salmonella enterica
-
-
-
additional information
?
-
enzyme BsAcuA acetylates BsAcsA and also SaAcsA from Staphylococcus aureus, as well as SeAcs from Salmonella enterica
-
-
-
additional information
?
-
-
enzyme inactivates AMP-forming acyl-CoA synthases by acetylating the epsilon-amino group of a conserved, catalytic lysine residue. Substrate recognition motif is PK/RTXS/T/V/NGKX2K/R. The first residue, threonine, is located 4 amino acids upstream of the acetylation site. The second residue can be S/T/V/N and is located two positions upstream of the acetylation site. No substrate: long-chain acyl-CoA synthase B
-
-
?
additional information
?
-
SePat has been reported to acetylate several metabolic enzymes, including ACS, glyceraldehyde-3-phosphate dehydrogenase (GapA), isocitrate lyase (AceA), and isocitrate dehydrogenase kinase (AceK), and to propionylate propionyl-CoA synthetase (PprE)
-
-
-
additional information
?
-
enzyme SePat acetylates SeAcs, but it fails to acetylate AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs) and Bacillus subtilis (BsAcsA)
-
-
-
additional information
?
-
the NDP-forming AcCoA domain is unable to produce acetyl-CoA from acetate, ATP, and CoA because the catalytic histidine, present e.g. in Escherichia coli PatZ, is replaced with an asparagine (N114) in SePat
-
-
-
additional information
?
-
enzyme SePat acetylates SeAcs, but it fails to acetylate AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs) and Bacillus subtilis (BsAcsA)
-
-
-
additional information
?
-
SePat has been reported to acetylate several metabolic enzymes, including ACS, glyceraldehyde-3-phosphate dehydrogenase (GapA), isocitrate lyase (AceA), and isocitrate dehydrogenase kinase (AceK), and to propionylate propionyl-CoA synthetase (PprE)
-
-
-
additional information
?
-
the NDP-forming AcCoA domain is unable to produce acetyl-CoA from acetate, ATP, and CoA because the catalytic histidine, present e.g. in Escherichia coli PatZ, is replaced with an asparagine (N114) in SePat
-
-
-
additional information
?
-
enzyme SePat acetylates SeAcs, but it fails to acetylate AMP-forming acetyl-CoA synthetase from Staphylococcus aureus (SaAcs) and Bacillus subtilis (BsAcsA)
-
-
-
additional information
?
-
SePat has been reported to acetylate several metabolic enzymes, including ACS, glyceraldehyde-3-phosphate dehydrogenase (GapA), isocitrate lyase (AceA), and isocitrate dehydrogenase kinase (AceK), and to propionylate propionyl-CoA synthetase (PprE)
-
-
-
additional information
?
-
the NDP-forming AcCoA domain is unable to produce acetyl-CoA from acetate, ATP, and CoA because the catalytic histidine, present e.g. in Escherichia coli PatZ, is replaced with an asparagine (N114) in SePat
-
-
-
additional information
?
-
no activity with AcsA substrate mutants SaAcsK546A, SaAcsK546R, and SaAcsK546Q by SaAcuA. SaAcuA does not acetylate any of the K546 variants. Malonyl-CoA is a poor substrate of SaAcuA
-
-
-
additional information
?
-
no activity with AcsA substrate mutants SaAcsK546A, SaAcsK546R, and SaAcsK546Q by SaAcuA. SaAcuA does not acetylate any of the K546 variants. Malonyl-CoA is a poor substrate of SaAcuA
-
-
-
