2.3.1.97: glycylpeptide N-tetradecanoyltransferase

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For detailed information about glycylpeptide N-tetradecanoyltransferase, go to the full flat file.

Reaction

Synonyms

CaNMT, cell division control protein 72, dipeptide N-myristoyltransferase 2, glycylpeptide N-tetradecanoyltransferase, glycylpeptide N-tetradecanoyltransferase 1, glycylpeptide N-tetradecanoyltransferase 2, HsNMT1, HsNMT2, LmNMT, More, myristoyl-CoA-protein N-myristoyltransferase, myristoyl-CoA: protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase 1, myristoyl-CoA:protein N-myristoyltransferase 2, myristoyl-CoA:protein N-myristoyltransferase type 2, myristoyl-coenzyme A:protein N-myristoyl transferase, myristoyl-coenzyme A:protein N-myristoyltransferase, myristoylating enzymes, myristoyltransferase, myristoyltransferase type 1, myristoyltransferase, protein N-, N-myristoyl transferase, N-myristoyltransferase, N-myristoyltransferase 1, N-myristoyltransferase 2, NMT, NMT 1, NMT 2, NMT-1, NMT-2, NMT1, Nmt1p, NMT2, peptide N-myristoyltransferase, peptide N-myristoyltransferase 1, peptide N-myristoyltransferase 2, protein N-myristoyltransferase, PVX_085815, TbNMT, type I N-myristoyltransferase, type II N-myristoyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.97 glycylpeptide N-tetradecanoyltransferase

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Results	in table
18	Activating Compound
5785	AA Sequence
24	Application
1	CAS Registry Number
45	Cloned(Commentary)
12	Crystallization (Commentary)
296	Disease/ Diagnostics
2	Expression
30	General Information
138	IC50 Value
560	Inhibitors
14	kcat/KM [mM/s]
79	Ki Value [mM]
102	KM Value [mM]
42	Localization
3	Metals/Ions
42	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
187	Organism
3	Oxidation Stability
244	PDB ID
28	pH Optimum
2	pH Range
1	pI Value
2	Posttranslational Modification
51	Protein Variants
41	Purification (Commentary)
37	Reaction
4	Reaction Type
174	Reference
1	Renatured (Commentary)
123	Source Tissue
31	Specific Activity [micromol/min/mg]
4	Storage Stability
289	Substrates and Products (Substrate)
37	Subunits
255	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
5	Temperature Stability [°C]
23	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase

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SYSTEMATIC NAME

IUBMB Comments

tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase

The enzyme catalyses the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.