2.3.1.94: 6-deoxyerythronolide-B synthase
This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.
Word Map on EC 2.3.1.94
-
2.3.1.94
-
synthases
-
aspergillus
-
nonribosomal
-
ketosynthase
-
macrolide
-
acyltransferase
-
starter
-
iterative
-
thioesterase
-
ketoreductase
-
actinomycete
-
melanin
-
coelicolor
-
erythraea
-
mycotoxin
-
saccharopolyspora
-
macrolactone
-
macrocyclic
-
polyene
-
actinorhodin
-
beta-ketoacyl
-
ochratoxin
-
citrinin
-
monascus
-
enoyl
-
deoxysugars
-
multimodular
-
fujikuroi
-
hygroscopicus
-
myxobacterium
-
verticillioides
-
avermitilis
-
avermectins
-
phosphopantetheinylated
-
macrolactams
-
pyrone
-
16-membered
-
phosphopantetheine
-
rifamycins
-
bimodular
-
epothilone
-
nrpss
-
halogenase
-
ansamycins
-
synthesis
-
ochraceus
-
pptases
-
antibioticus
-
biotechnology
-
enediyne
-
meroterpenoids
-
analysis
-
4'-phosphopantetheine
- 2.3.1.94
- synthases
- aspergillus
-
nonribosomal
-
ketosynthase
-
macrolide
- acyltransferase
-
starter
-
iterative
-
thioesterase
- ketoreductase
-
actinomycete
- melanin
- coelicolor
- erythraea
-
mycotoxin
- saccharopolyspora
-
macrolactone
-
macrocyclic
-
polyene
-
actinorhodin
-
beta-ketoacyl
-
ochratoxin
- citrinin
- monascus
-
enoyl
-
deoxysugars
-
multimodular
- fujikuroi
- hygroscopicus
-
myxobacterium
- verticillioides
- avermitilis
- avermectins
-
phosphopantetheinylated
-
macrolactams
-
pyrone
-
16-membered
- phosphopantetheine
- rifamycins
-
bimodular
-
epothilone
-
nrpss
- halogenase
-
ansamycins
- synthesis
- ochraceus
- pptases
- antibioticus
- biotechnology
-
enediyne
-
meroterpenoids
- analysis
- 4'-phosphopantetheine
Reaction
+ 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = + 7 CoA + 6 CO2 + + 6 NADP+
Synonyms
6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
propanoyl-CoA + (2S)-methylmalonyl-CoA + NADPH
(3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyloxan-2-one + ?
-
-
-
?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
(3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyltetrahydro-2H-pyran-2-one + ?
-
product of truncated enzyme consisting of loading didomain-module1-module2+thioesterase
-
?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
(3R,5R,6S)-6-[(2S,3R)-3-hydroxypentan-2-yl]-3,5-dimethyldihydro-2H-pyran-2,4(3H)-dione + ?
-
product of truncated enzyme consisting of loading didomain-module1-module2-module3+thioesterase
-
?
propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+
8-ethyl-8-desmethyl-6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
putative analog, 8-ethyl-8-desmethyl-6-deoxyerythronolide B, is generated by the assembly line in the presence of non-limiting concentrations of ethylmalonyl-CoA and is produced in comparable amounts to the natural 6-dEB product
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
6 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
formation of a key intermediate in the biosynthesis of erythromycin
-
?
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
-
-
?
?
-
-
unidirectional translocation of the growing polyketide chain along the 6-deoxyerythronolide B synthase, ratchet mechanism, overview
-
-
?
additional information
?
-
the cis-acyltransferase domain from DEBS module 3 transfers a methylmalonyl extender unit from the corresponding carboxyacyl-CoA precursor onto the phosphopantetheine arm of the acyl carrier protein within the same module. The presence of the acyl carrier protein has little effect on the specificity of the cis-acyltransferase domain for carboxyacyl-CoA substrates, but has a marked influence on the corresponding specificity parameters for the trans-acyltransferases from the disorazole and kirromycin synthases. Comparative analysis of the substrate specificity
-
-
?