2.3.1.94: 6-deoxyerythronolide-B synthase
This is an abbreviated version!
For detailed information about 6-deoxyerythronolide-B synthase, go to the full flat file.
Word Map on EC 2.3.1.94
-
2.3.1.94
-
synthases
-
aspergillus
-
nonribosomal
-
ketosynthase
-
macrolide
-
acyltransferase
-
starter
-
iterative
-
thioesterase
-
ketoreductase
-
actinomycete
-
melanin
-
coelicolor
-
erythraea
-
mycotoxin
-
saccharopolyspora
-
macrolactone
-
macrocyclic
-
polyene
-
actinorhodin
-
beta-ketoacyl
-
ochratoxin
-
citrinin
-
monascus
-
enoyl
-
deoxysugars
-
multimodular
-
fujikuroi
-
hygroscopicus
-
myxobacterium
-
verticillioides
-
avermitilis
-
avermectins
-
phosphopantetheinylated
-
macrolactams
-
pyrone
-
16-membered
-
phosphopantetheine
-
rifamycins
-
bimodular
-
epothilone
-
nrpss
-
halogenase
-
ansamycins
-
synthesis
-
ochraceus
-
pptases
-
antibioticus
-
biotechnology
-
enediyne
-
meroterpenoids
-
analysis
-
4'-phosphopantetheine
- 2.3.1.94
- synthases
- aspergillus
-
nonribosomal
-
ketosynthase
-
macrolide
- acyltransferase
-
starter
-
iterative
-
thioesterase
- ketoreductase
-
actinomycete
- melanin
- coelicolor
- erythraea
-
mycotoxin
- saccharopolyspora
-
macrolactone
-
macrocyclic
-
polyene
-
actinorhodin
-
beta-ketoacyl
-
ochratoxin
- citrinin
- monascus
-
enoyl
-
deoxysugars
-
multimodular
- fujikuroi
- hygroscopicus
-
myxobacterium
- verticillioides
- avermitilis
- avermectins
-
phosphopantetheinylated
-
macrolactams
-
pyrone
-
16-membered
- phosphopantetheine
- rifamycins
-
bimodular
-
epothilone
-
nrpss
- halogenase
-
ansamycins
- synthesis
- ochraceus
- pptases
- antibioticus
- biotechnology
-
enediyne
-
meroterpenoids
- analysis
- 4'-phosphopantetheine
Reaction
+ 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = + 7 CoA + 6 CO2 + + 6 NADP+
Synonyms
6-deoxyerythronolide B, 6-deoxyerythronolide B synthase, DEBS, DEBS1, DEBS2, DEBS3, deoxyerythronolide B synthase, deoxyerythronolide B synthase 1, deoxyerythronolide B synthase 2, deoxyerythronolide B synthase 3, eryA, erythromycin polyketide synthase, erythronolide condensing enzyme, erythronolide synthase, PKS, polyketide synthase, synthase, erythronolide
ECTree
Advanced search results
Reference
Reference on EC 2.3.1.94 - 6-deoxyerythronolide-B synthase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Roberts, G.; Leadly, P.F.
Use of [3H]tetrahydrocerulenin to assay condensing enzyme activity in Streptomyces erythreus
Biochem. Soc. Trans.
12
642-643
1984
Saccharopolyspora erythraea
-
Khosla, C.; Tang, Y.; Chen, A.Y.; Schnarr, N.A.; Cane, D.E.
Structure and mechanism of the 6-deoxyerythronolide B synthase
Annu. Rev. Biochem.
76
195-221
2007
Saccharopolyspora erythraea
Wong, F.T.; Chen, A.Y.; Cane, D.E.; Khosla, C.
Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases
Biochemistry
49
95-102
2010
Saccharopolyspora erythraea (Q03131)
Kapur, S.; Worthington, A.; Tang, Y.; Cane, D.E.; Burkart, M.D.; Khosla, C.
Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase
Bioorg. Med. Chem. Lett.
18
3034-3038
2008
Saccharopolyspora erythraea
Pistorino, M.; Pfeifer, B.A.
Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli
Biotechnol. Prog.
25
1364-1371
2009
Saccharopolyspora erythraea
Wang, Y.; Pfeifer, B.
6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli
Metab. Eng.
10
33-38
2008
Saccharopolyspora erythraea
Katz, L.
The DEBS paradigm for type I modular polyketide synthases and beyond
Methods Enzymol.
459
113-142
2009
Saccharopolyspora erythraea
Tsai, S.C.; Miercke, L.J.W.; Krucinski, J.; Gokhale, R.; Chen, J.C.H.; Foster, P.G.; Cane, D.E.; Khosla, C.; Stroud, R.M.
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel
Proc. Natl. Acad. Sci. USA
98
14808-14813
2001
Saccharopolyspora erythraea (Q03133)
Pfeifer, B.A.; Admiraal, S.J.; Gramajo, H.; Cane, D.E.; Khosla, C.
Biosynthesis of complex polyketides in a metabolically engieered strain of Escherichia coli
Science
291
1790-1792
2001
Saccharopolyspora erythraea (Q03131), Saccharopolyspora erythraea (Q03132), Saccharopolyspora erythraea (Q03133), Saccharopolyspora erythraea
Charkoudian, L.K.; Liu, C.W.; Capone, S.; Kapur, S.; Cane, D.E.; Togni, A.; Seebach, D.; Khosla, C.
Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase
Protein Sci.
20
1244-1255
2011
Saccharopolyspora erythraea
Kumpfmueller, J.; Methling, K.; Fang, L.; Pfeifer, B.A.; Lalk, M.; Schweder, T.
Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis
Appl. Microbiol. Biotechnol.
100
1209-1220
2016
Saccharopolyspora erythraea (Q03131 and Q03132 and Q03133), Saccharopolyspora erythraea
Dunn, B.J.; Watts, K.R.; Robbins, T.; Cane, D.E.; Khosla, C.
Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases
Biochemistry
53
3796-3806
2014
Saccharopolyspora erythraea (Q03131 and Q03132 and Q03133)
Argyropoulos, P.; Bergeret, F.; Pardin, C.; Reimer, J.M.; Pinto, A.; Boddy, C.N.; Schmeing, T.M.
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis
Biochim. Biophys. Acta
1860
486-497
2016
Saccharopolyspora erythraea (Q03133)
Lowry, B.; Robbins, T.; Weng, C.H.; OBrien, R.V.; Cane, D.E.; Khosla, C.
In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase
J. Am. Chem. Soc.
135
16809-16812
2013
Saccharopolyspora erythraea (Q03131 and Q03132 and Q03133)
Edwards, A.L.; Matsui, T.; Weiss, T.M.; Khosla, C.
Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase
J. Mol. Biol.
426
2229-2245
2014
Saccharopolyspora erythraea (Q03131 and Q03132 and Q03133), Saccharopolyspora erythraea
Koryakina, I.; Kasey, C.; McArthur, J.B.; Lowell, A.N.; Chemler, J.A.; Li, S.; Hansen, D.A.; Sherman, D.H.; Williams, G.J.
Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
ACS Chem. Biol.
12
114-123
2017
Saccharopolyspora erythraea (Q03133)
Robbins, T.; Kapilivsky, J.; Cane, D.E.; Khosla, C.
Roles of conserved active site residues in the ketosynthase domain of an assembly line polyketide synthase
Biochemistry
55
4476-4484
2016
Saccharopolyspora erythraea (Q03131 and Q03132 and Q03133)
html completed