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2 acetyl-CoA
acetoacetyl-CoA + CoA
2 acetyl-CoA
CoA + acetoacetyl-CoA
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
acetoacetyl-CoA + CoA
2 acetyl-CoA
acetoacetyl-S-pantetheine + acetyldithio-CoA
acetyl-S-pantetheine + 3-ketobutyryldithio-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
acetyl-CoA + acetyldithio-CoA
CoA + 3-ketobutyryldithio-CoA
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-
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r
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
CoA + acetoacetyl-10-bis-demethylpantetheine 11-pivaloate
acetyl-CoA + acetyl-10-bis-demethylpantetheine 11-pivaloate
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-S-(11-methoxymethyl)pantetheine
acetyl-CoA + acetyl-S-(11-methoxymethyl)pantetheine
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?
CoA + acetoacetyl-S-(11-t-butyldimethylsilyl)pantetheine
acetyl-CoA + acetyl-S-(11-t-butyldimethylsilyl)pantetheine
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?
CoA + acetoacetyl-S-(D-pantetheine) 11-pivalate
acetyl-CoA + acetyl-S-(D-pantetheine) 11-pivalate
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?
CoA + acetoacetyl-S-(L-pantetheine) 11-pivalate
acetyl-CoA + acetyl-S-(L-pantetheine) 11-pivalate
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?
CoA + acetoacetyl-S-homopantetheine 12-pivalate
acetyl-CoA + acetyl-S-homopantetheine 12-pivalate
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?
CoA + acetoacetyl-S-pantetheine
acetyl-CoA + acetyl-S-pantetheine
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?
additional information
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2 acetyl-CoA
acetoacetyl-CoA + CoA
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?
2 acetyl-CoA
acetoacetyl-CoA + CoA
the thiolase is involved in the synthesis and catabolism of fatty acids
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme is responsible for supplying the precursors for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme is responsible for supplying the precursors for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme catalyzes a reaction in the mevalonate pathway
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
the enzyme catalyzes a reaction in the mevalonate pathway
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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ir
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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?
2 acetyl-CoA
CoA + acetoacetyl-CoA
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r
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
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-
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?
2-methylacetoacetyl-CoA + CoA
acetyl-CoA + propionyl-CoA
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cleavage of 2-methylacetoacetyl-CoA in the isoleucine catabolism
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?
acetoacetyl-CoA + CoA
2 acetyl-CoA
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the enzyme shows preference for the thiolytic reaction direction
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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?
acetoacetyl-CoA + CoA
2 acetyl-CoA
coupled reaction assay in which the product of the thiolase reaction, acetyl-CoA, becomes the substrate for citrate synthase
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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r
acetoacetyl-CoA + CoA
2 acetyl-CoA
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interconversion of 2 acetyl-CoA into acetoacetyl-CoA in the ketone body metabolism
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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?
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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enzyme deficiency affects isoleucine and ketone body metabolism
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
involved in fatty acid synthesis
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r
acetyl-CoA + acetyl-CoA
CoA + acetoacetyl-CoA
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r
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
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?
acetyl-CoA + propionyl-CoA
CoA + 3-oxopentanoyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA binding mode, overview
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA substrate binding structure, overview
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA substrate binding structure, overview
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
CoA binding mode, overview
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in autotrophic carbon fixation
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
the enzyme is involved in autotrophic carbon fixation
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?
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
2 acetyl-CoA
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the enzyme of the biosynthetic pathway for polyhydroxyalkanoates
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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rate of synthesis is 0.31 and 0.08 the rate of thiolysis for isoenzyme A and B, respectively
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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specific for acetoacetyl-CoA, no activity with ketodecanoyl-CoA, dithiothreitol and 2-mercaptoethanol
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
cytosolic thiolase I is essential for the mevalonate pathway
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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enzyme of fatty acid oxidation cycle
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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enzyme has both thiolase and 3-hydroxy-3-methylglutaryl-CoA reductase activity
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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thiolase II from constitutive mutant is specific for acetoacetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, ir
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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thiolysis is strongly preferred
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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peroxisomal thiolase most probably catalyzes the first reaction in peroxisomal cholesterol and dolichol synthesis
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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liver mitochondrial isoenzyme catalyzes the first step in biosynthesis of ketone bodies
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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enzyme has both thiolase and acetyl-CoA:acyl carrier protein transacylase activity
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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thiolysis is preferred, highly specific for acetoacetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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-
r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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?, r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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most active in thiolysis
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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involved in generation of acetoacetyl-CoA for poly-beta-hydroxybutyrate synthesis
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?
additional information
?
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Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions
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additional information
?
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Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions
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additional information
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Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions
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additional information
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the enzyme shows degradative thiolase activity by converting 3-ketoacyl-CoA to acyl-CoA
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-ketoacyl-CoA to acyl-CoA
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-ketoacyl-CoA to acyl-CoA
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-oxoacyl-CoA to acyl-CoA
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?
additional information
?
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the bound CoA substrate is located within the deep cleft formed by subdomains I, II, and III. The thiol group of CoA is located in the vicinity of the catalytic site for the degradation reaction, whereas,the adenosine nucleotide moiety is exposed on the surface. Unlike enzyme ReH16_A1887, that shows substantial structural changeupon the binding of CoA, the CoA-bound form of enzyme ReH16_B0759 exhibits quite similar structure to the apoform of the protein except for residual movement of Arg220. Moreover, the CoA binding mode of enzyme ReH16_B0759 is quite different from that of enzyme ReH16_A1887
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-ketoacyl-CoA to acyl-CoA
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?
additional information
?
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the bound CoA substrate is located within the deep cleft formed by subdomains I, II, and III. The thiol group of CoA is located in the vicinity of the catalytic site for the degradation reaction, whereas,the adenosine nucleotide moiety is exposed on the surface. Unlike enzyme ReH16_A1887, that shows substantial structural changeupon the binding of CoA, the CoA-bound form of enzyme ReH16_B0759 exhibits quite similar structure to the apoform of the protein except for residual movement of Arg220. Moreover, the CoA binding mode of enzyme ReH16_B0759 is quite different from that of enzyme ReH16_A1887
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-ketoacyl-CoA to acyl-CoA
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?
additional information
?
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the enzyme shows degradative thiolase activity by converting 3-oxoacyl-CoA to acyl-CoA
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?
additional information
?
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the catalytic triad of BktBalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of BktBalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of BktBalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of PhaAalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of PhaAalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of PhaAalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of PhaAalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of PhaAalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of BktBalpha is likely to be Ser-His-His
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?
additional information
?
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the catalytic triad of BktBalpha is likely to be Ser-His-His
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?
additional information
?
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no activity is observed with acetyl-CoA
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?
additional information
?
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the enzyme plays a more important role in the activation of ketogenesis in Squalus acanthias than in mammals and birds
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?