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0.098
2'-N-ethyl netilmicin
pH 8.0, 37°C
0.097
2'-N-ethylnetilmicin
pH 8.0, 37°C
0.466
butirosin
-
pH 6.0, 37°C
0.107 - 0.113
butirosin A
1.03
Ciprofloxacin
-
AAC(6')-Ib-cr variant
0.0002 - 0.45
fortimicin A
0.388
gentamicin B
-
pH 6.0, 37°C
1.01
gentamicin C
-
wild-type enzyme
1.17
gentamycin
pH 7.5, 25°C
3.08
neomycin B
-
AAC(6')-Ib, wild type
1.08
Norfloxacin
-
AAC(6')-Ib-cr variant
0.0004 - 0.059
paromomycin
0.0019
poly-L-Lys
pH 7.5, 37°C
0.317
propionyl-CoA
-
pH 6.0, 37°C
0.01
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme Y147A
0.035
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.06
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme L76P
0.07
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme Y147F
0.11
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.17
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.173
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme W164A
0.18
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme H74A
0.23
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme L76A
0.4
acetyl-CoA
-
pH 6.0, 37°C, wild-type enzyme
0.403
acetyl-CoA
-
pH 6.0, 37°C
0.403
acetyl-CoA
-
pH 6.0, 37°C, wild-type enzyme
0.99
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme E72A
1
acetyl-CoA
-
reaction with AAC (6')-Ib' domain
1.03
acetyl-CoA
-
AAC(6')-Ib-cr variant
1.2
acetyl-CoA
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
1.3
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
1.51
acetyl-CoA
pH 7.5, 25°C
1.61
acetyl-CoA
-
wild-type enzyme
1.62
acetyl-CoA
full length enzyme, pH 7.5, 25°C
2.32
acetyl-CoA
-
AAC(6')-Ib, wild type
5.23
acetyl-CoA
-
AAC(6')-Ib-cr variant
12.1
acetyl-CoA
isolated AAC(6') domain, pH 7.5, 25°C
0.003
amikacin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.03
amikacin
-
pH 6.0, 37°C, mutant enzyme L76A
0.04
amikacin
-
pH 6.0, 37°C, mutant enzyme H74A
0.05
amikacin
-
pH 6.0, 37°C, mutant enzyme E72A
0.106
amikacin
-
pH 6.0, 37°C
0.11
amikacin
-
pH 6.0, 37°C, wild-type enzyme
0.11
amikacin
pH not specified in the publication, temperature not specified in the publication
0.2
amikacin
pH not specified in the publication, temperature not specified in the publication
0.29
amikacin
-
wild-type enzyme
0.328
amikacin
pH 8.0, 37°C
0.496
amikacin
pH 8.0, 37°C
2.92
amikacin
full length enzyme, pH 7.5, 25°C
3.5
amikacin
-
reaction with AAC (6')-Ib' domain
7.09
amikacin
isolated AAC(6') domain, pH 7.5, 25°C
0.021
arbekacin
pH 8.0, 37°C
0.077
arbekacin
pH 8.0, 37°C
0.57
arbekacin
pH not specified in the publication, temperature not specified in the publication
17
arbekacin
pH not specified in the publication, temperature not specified in the publication
0.107
butirosin A
pH 8.0, 37°C
0.113
butirosin A
pH 8.0, 37°C
0.04
dibekacin
pH 8.0, 37°C
0.127
dibekacin
pH 8.0, 37°C
0.25
dibekacin
pH not specified in the publication, temperature not specified in the publication
0.632
dibekacin
-
pH 6.0, 37°C
1.3
dibekacin
-
reaction with AAC (6')-Ib' domain
85
dibekacin
pH not specified in the publication, temperature not specified in the publication
0.0002
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.0008
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.006
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.28
fortimicin A
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.45
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.016
gentamicin
pH 8.0, 37°C
0.055
gentamicin
pH 8.0, 37°C
1.11
gentamicin
full length enzyme, pH 7.5, 25°C
2
gentamicin
-
reaction with AAC (6')-Ib' domain
3.33
gentamicin
isolated AAC(6') domain, pH 7.5, 25°C
0.05
isepamicin
pH not specified in the publication, temperature not specified in the publication
0.62
isepamicin
pH 8.0, 37°C
0.779
isepamicin
pH 8.0, 37°C
2.4
isepamicin
-
reaction with AAC (6')-Ib' domain
25
isepamicin
pH not specified in the publication, temperature not specified in the publication
0.04
kanamycin
pH not specified in the publication, temperature not specified in the publication
0.207
kanamycin
pH 7.5, 25°C
2.13
kanamycin
isolated AAC(6') domain, pH 7.5, 25°C
3.81
kanamycin
full length enzyme, pH 7.5, 25°C
10
kanamycin
pH not specified in the publication, temperature not specified in the publication
0.01
kanamycin A
-
pH 6.0, 37°C, mutant enzyme Y147A
0.03
kanamycin A
-
pH 6.0, 37°C, mutant enzyme Y147F
0.033
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.038
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.05
kanamycin A
-
pH 6.0, 37°C, mutant enzyme H74A
0.08
kanamycin A
-
pH 6.0, 37°C, mutant enzyme W164A
0.19
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.27
kanamycin A
-
pH 6.0, 37°C, mutant enzyme L76A
0.55
kanamycin A
-
pH 6.0, 37°C, mutant enzyme E72A
0.816
kanamycin A
-
pH 6.0, 37°C
0.816
kanamycin A
-
pH 6.0, 37°C, wild-type enzyme
0.82
kanamycin A
-
pH 6.0, 37°C, wild-type enzyme
1.1
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
1.68
kanamycin A
-
wild-type enzyme
1.7
kanamycin A
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
2.4
kanamycin A
-
reaction with AAC (6')-Ib' domain
0.06
kanamycin B
pH 8.0, 37°C
0.181
kanamycin B
pH 8.0, 37°C
1.08
kanamycin B
-
pH 6.0, 37°C
2.27
kanamycin B
-
AAC(6')-Ib, wild type
5.25
kanamycin B
-
AAC(6')-Ib-cr variant
0.002
neamine
-
pH 6.0, 37°C, mutant enzyme L76P
0.004
neamine
-
pH 6.0, 37°C, mutant enzyme Y147A
0.028
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.029
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.048
neamine
-
pH 6.0, 37°C, mutant enzyme W164A
0.05
neamine
-
pH 6.0, 37°C, mutant enzyme Y147F
0.066
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.15
neamine
-
pH 6.0, 37°C, mutant enzyme H74A
0.38
neamine
-
pH 6.0, 37°C, mutant enzyme L76A
0.419
neamine
-
pH 6.0, 37°C
0.419
neamine
-
pH 6.0, 37°C, wild-type enzyme
0.42
neamine
-
pH 6.0, 37°C, wild-type enzyme
0.43
neamine
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.44
neamine
-
pH 6.0, 37°C, mutant enzyme E72A
1.3
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.001
neomycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.04
neomycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.07
neomycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.16
neomycin
-
pH 6.0, 37°C, mutant enzyme L76A
0.19
neomycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.2
neomycin
-
pH 6.0, 37°C, wild-type enzyme
0.3
neomycin
-
wild-type enzyme
0.32
neomycin
pH not specified in the publication, temperature not specified in the publication
1.1
neomycin
-
pH 6.0, 37°C, mutant enzyme E72A
6
neomycin
-
reaction with AAC (6')-Ib' domain
7.8
neomycin
pH not specified in the publication, temperature not specified in the publication
9.06
neomycin
full length enzyme, pH 7.5, 25°C
11.1
neomycin
isolated AAC(6') domain, pH 7.5, 25°C
0.057
neomycin C
pH 8.0, 37°C
0.06
neomycin C
pH 8.0, 37°C
0.135
neomycin C
-
pH 6.0, 37°C, mutant enzyme W164A
0.205
neomycin C
-
pH 6.0, 37°C
0.205
neomycin C
-
pH 6.0, 37°C, wild-type enzyme
0.2
netilmicin
-
pH 7.5
0.3
netilmicin
pH not specified in the publication, temperature not specified in the publication
0.512
netilmicin
-
pH 6.0, 37°C
0.73
netilmicin
pH not specified in the publication, temperature not specified in the publication
1.3
netilmicin
-
reaction with AAC (6')-Ib' domain
1.91
netilmicin
full length enzyme, pH 7.5, 25°C
3.21
netilmicin
isolated AAC(6') domain, pH 7.5, 25°C
0.0004
paromomycin
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.026
paromomycin
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.059
paromomycin
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.01
ribostamycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.02
ribostamycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.04
ribostamycin
pH 8.0, 37°C
0.046
ribostamycin
-
pH 6.0, 37°C, mutant enzyme W164A
0.072
ribostamycin
pH 8.0, 37°C
0.12
ribostamycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.15
ribostamycin
-
pH 6.0, 37°C, mutant enzyme L76A
0.23
ribostamycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.338
ribostamycin
-
pH 6.0, 37°C
0.338
ribostamycin
-
pH 6.0, 37°C, wild-type enzyme
0.34
ribostamycin
-
pH 6.0, 37°C, wild-type enzyme
0.35
ribostamycin
-
pH 6.0, 37°C, mutant enzyme E72A
3.88
ribostamycin
full length enzyme, pH 7.5, 25°C
5.7
ribostamycin
isolated AAC(6') domain, pH 7.5, 25°C
0.051
sisomicin
pH 8.0, 37°C
0.13
sisomicin
pH 8.0, 37°C
0.16
sisomicin
pH not specified in the publication, temperature not specified in the publication
0.37
sisomicin
-
pH 6.0, 37°C
0.49
sisomicin
pH not specified in the publication, temperature not specified in the publication
2.42
sisomicin
pH 7.5, 25°C
2.93
sisomicin
full length enzyme, pH 7.5, 25°C
5.35
sisomicin
isolated AAC(6') domain, pH 7.5, 25°C
0.022
tobramicin
pH 8.0, 37°C
0.085
tobramicin
pH 8.0, 37°C
0.004
tobramycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.01
tobramycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.08
tobramycin
pH not specified in the publication, temperature not specified in the publication
0.1
tobramycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.3
tobramycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.67
tobramycin
pH not specified in the publication, temperature not specified in the publication
0.8
tobramycin
-
wild-type enzyme
0.89
tobramycin
-
pH 6.0, 37°C, mutant enzyme L76A
1.1
tobramycin
-
pH 6.0, 37°C, wild-type enzyme
1.1
tobramycin
-
pH 6.0, 37°C, mutant enzyme E72A
1.11
tobramycin
-
pH 6.0, 37°C
1.2
tobramycin
pH 7.5, 25°C
3.73
tobramycin
isolated AAC(6') domain, pH 7.5, 25°C
3.84
tobramycin
full length enzyme, pH 7.5, 25°C