2.3.1.82: aminoglycoside 6'-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 6'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.82

2.3.1.82

quinolone

plasmid-mediated

ciprofloxacin

amikacin

extended-spectrum

fluoroquinolones

gyras

esbls

integrons

aac6\'-ib-cr

tobramycin

aac6\'-ib

blactx-m-15

esbl-producing

aminoglycoside-modifying

blatem-1

blactx-m

blashv

blaoxa-1

netilmicin

oqxab

resistance-determining

fluoroquinolone-resistant

ciprofloxacin-resistant

quinolone-resistant

carbapenemase

aminoglycoside-resistant

ctx-m-3

blacmy-2

isecp1

aph3\'-ia

qrdrs

blakpc-2

carbapenemase-producing

nonduplicate

sisomicin

blashv-12

ctx-m-15-producing

esbl-positive

co-harbored

dfra12

arbekacin

inchi2

co-harbouring

ctx-m-producing

analysis

ndm-1-producing

cephalosporin-resistant

medicine

Reaction

Synonyms

6'-acetyltransferase-Im, 6'-N-acetyltransferase type Ib, AAC, aac(3)-Ib/aac(6')-Ib, AAC(3)-Ib/AAC(6')-Ib', AAC(6'), AAC(6')-I, AAC(6')-Iaf, AAC(6')-IaI, AAC(6')-Iaj, AAC(6')-Ian, AAC(6')-Ib, AAC(6')-Ib-cr, AAC(6')-Ie, AAC(6')-Ie/APH(2")-Ia, AAC(6')-Ie/APH(2'')-Ia, AAC(6')-Ie/APH(2')-Ia, AAC(6')-Ig, AAC(6')-Ih, AAC(6')-Ii, AAC(6')-Im, AAC(6')-Isa, AAC(6')-Iy, AAC(6')-Iz acetyltransferase, AAC(6)-Iak, aac(6)-Ib, AAC3-I, aacA-aphD, acetyltransferase, aminoglycoside 6'-N-, acetyltransferase, kanamycin, acetyltransferase-6'-aminoglycoside phosphotransferase-2", aminoglycoside (3) acetyltransferase AAC(3)-Ia, aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein, aminoglycoside 6'-acetyltransferase-Ie, aminoglycoside 6'-N-acetyltransferase, aminoglycoside 6'-N-acetyltransferase Ib, aminoglycoside 6'-N-acetyltransferase type Ib, aminoglycoside 6'-N-acetyltransferase type Ii, aminoglycoside 6-N-acetyltransferase, aminoglycoside acetyltransferase, aminoglycoside acetyltransferase eis, aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, aminoglycoside N(6')-acetyltransferase type 1, aminoglycoside N-6'-acetyltransferase, aminoglycoside N-6'-acetyltransferase Ii, aminoglycoside N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6'-N-acetyltransferase, aminoglycoside-6-N-acetyltransferase, ANT(3'')-Ii/AAC(6')-IId, EC 2.3.1.55, meta-AAC0020

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.82 aminoglycoside 6'-N-acetyltransferase

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Results	in table
2538	AA Sequence
8	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Cofactor
11	Crystallization (Commentary)
1	Expression
7	General Information
3	General Stability
13	IC50 Value
85	Inhibitors
65	kcat/KM [mM/s]
78	Ki Value [mM]
230	KM Value [mM]
1	Localization
1	Metals/Ions
10	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
114	Organism
24	PDB ID
15	pH Optimum
1	pH Range
1	Posttranslational Modification
50	Protein Variants
16	Purification (Commentary)
2	Reaction
6	Reaction Type
93	Reference
2	Specific Activity [micromol/min/mg]
2	Storage Stability
361	Substrates and Products (Substrate)
10	Subunits
97	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
186	Turnover Number [1/s]

Purification

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Purification on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase

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6 entries

both acetyltransferase domains of the bifunctional enzyme AAC(3)-Ib/AAC(6')-Ib' are cloned and purified

Pseudomonas aeruginosa

672253

His-tagged AAC(6')-Isa

Streptomyces albulus

Q764C8

659093

Ni-NTA column chromatography and Superdex S200 gel filtration

uncultured bacterium

A0A059WZ16

755693

on a His-Bind NiNTA column

Mycobacterium tuberculosis

706524

on a Ni-NTA and a Superdex S-75 column, the His6 tag is cleaved using thrombin

partial

recombinant AAC(6')-Iaf is purified using Ni-nitrilotriacetic acid agarose, native AAC(6')-Iaf from Pseudomonas aeruginosa on an anti-AAC(6')-Iaf-IgG coupled and NHS-activated Sepharose column

Pseudomonas aeruginosa

C4TGI5

701732

strain GN315

Pseudomonas aeruginosa

636901

unseparable from 2-O-aminoglycoside phosphotransferase by affinity chromatography or sucrose density gradient ultracentrifugation

Staphylococcus aureus

636902