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2.3.1.82: aminoglycoside 6'-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 6'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.82

Reaction

acetyl-CoA
+
kanamycin-B
=
CoA
 +
N6'-acetylkanamycin-B

Synonyms

6'-acetyltransferase-Im, 6'-N-acetyltransferase type Ib, AAC, aac(3)-Ib/aac(6')-Ib, AAC(3)-Ib/AAC(6')-Ib', AAC(6'), AAC(6')-I, AAC(6')-Iaf, AAC(6')-IaI, AAC(6')-Iaj, AAC(6')-Ian, AAC(6')-Ib, AAC(6')-Ib-cr, AAC(6')-Ie, AAC(6')-Ie/APH(2")-Ia, AAC(6')-Ie/APH(2'')-Ia, AAC(6')-Ie/APH(2')-Ia, AAC(6')-Ig, AAC(6')-Ih, AAC(6')-Ii, AAC(6')-Im, AAC(6')-Isa, AAC(6')-Iy, AAC(6')-Iz acetyltransferase, AAC(6)-Iak, aac(6)-Ib, AAC3-I, aacA-aphD, acetyltransferase, aminoglycoside 6'-N-, acetyltransferase, kanamycin, acetyltransferase-6'-aminoglycoside phosphotransferase-2", aminoglycoside (3) acetyltransferase AAC(3)-Ia, aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein, aminoglycoside 6'-acetyltransferase-Ie, aminoglycoside 6'-N-acetyltransferase, aminoglycoside 6'-N-acetyltransferase Ib, aminoglycoside 6'-N-acetyltransferase type Ib, aminoglycoside 6'-N-acetyltransferase type Ii, aminoglycoside 6-N-acetyltransferase, aminoglycoside acetyltransferase, aminoglycoside acetyltransferase eis, aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, aminoglycoside N(6')-acetyltransferase type 1, aminoglycoside N-6'-acetyltransferase, aminoglycoside N-6'-acetyltransferase Ii, aminoglycoside N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6'-N-acetyltransferase, aminoglycoside-6-N-acetyltransferase, ANT(3'')-Ii/AAC(6')-IId, EC 2.3.1.55, meta-AAC0020

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.82 aminoglycoside 6'-N-acetyltransferase

KM Value

KM Value on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.049
2'-N-ethyl netilmicin
S 0.5 value, Hill coefficient 1.39, pH 8.0, 37°C
0.0183
2'-N-ethylnetilmicin
S 0.5 value, Hill coefficient 2.28, pH 8.0, 37°C
0.0033 - 0.215
acetyl-CoA
0.00055 - 2.19
amikacin
0.0059 - 0.399
arbekacin
0.014
butirosin
-
pH 6.0, 37°C
0.0173 - 0.0216
butirosin A
9.3
butyryl-CoA
-
reaction with tobramycin, wild-type enzyme
0.07
Ciprofloxacin
-
AAC(6')-Ib-cr variant
0.00038 - 0.582
dibekacin
0.0254 - 0.07
fortimicin A
0.00504 - 0.653
gentamicin
0.0223
gentamicin B
-
pH 6.0, 37°C
0.0082
gentamicin C
-
wild-type enzyme
0.022
gentamycin
K 0.5 value, Hill coefficient 3.14, pH 7.5, 25°C
0.0003 - 0.404
isepamicin
0.00202 - 0.346
kanamycin
0.001 - 3.49
kanamycin A
0.00027 - 0.9
kanamycin B
0.04188
lividomycin A
pH 8.0, 30°C
0.58 - 0.82
malonyl-CoA
0.0686
n-butyryl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.0161
n-propionyl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.0058 - 0.509
neamine
0.0012 - 0.47
neomycin
0.53
neomycin A
-
-
0.00052 - 0.02
neomycin B
0.00531 - 0.25
neomycin C
0.001 - 2.44
netilmicin
0.067
Norfloxacin
-
AAC(6')-Ib-cr variant
0.324 - 0.771
paromomycin
0.038
poly-L-Lys
pH 7.5, 37°C
0.0195 - 0.27
propionyl-CoA
0.0062 - 0.306
ribostamycin
0.0022 - 0.038
sisomicin
0.0029 - 0.216
tobramicin
0.00353 - 1.15
tobramycin