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2.3.1.81: aminoglycoside 3-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.81

Reaction

acetyl-CoA
+
a 2-deoxystreptamine antibiotic
=
CoA
 +
N3-acetyl-2-deoxystreptamine antibiotic

Synonyms

3'-aminoglycoside acetyltransferase, 3-N-acetyltransferase, 3-N-aminoglycoside acetyltransferase, AAC, AAC (3)-IIIb, AAC(3), AAC(3)-Id, AAC(3)-Ig acetyltransferase, Aac(3)-IIIb, AAC(3)-IV, AAC(3)-XI, AAC(6')-APH(2''), AAC-IIIb, AAC-VIa, aac3-Ia, AAC3-IV aminoglycoside acetyltransferase, AacC-A7 acetyltransferase, aminoglycoside 3-acetyltransferase, aminoglycoside 3-acetyltransferase-IIIb, aminoglycoside 3-N-acetyltransferase, aminoglycoside 3-N-acetyltransferase type XI, aminoglycoside acetyltransferase, aminoglycoside acetytransferase, aminoglycoside N(3)-acetyltransferase III, aminoglycoside N3-acetyltransferase, aminoglycoside N3-acetyltransferase-IIIb, aminoglycoside N3-acetyltransferase-VIa, Eis, Eis2, Enhanced in Intracellular Survival, More, RbmI

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.81 aminoglycoside 3-N-acetyltransferase

Substrates Products

Substrates Products on EC 2.3.1.81 - aminoglycoside 3-N-acetyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-bromo-thiophene-2-carbonyl-S-CoA + amikacin
?
show the reaction diagram
-
-
-
-
?
4-bromo-thiophene-2-carbonyl-S-CoA + gentamicin
?
show the reaction diagram
-
-
-
-
?
4-bromo-thiophene-2-carbonyl-S-CoA + neomycin B
?
show the reaction diagram
-
-
-
-
?
4-bromo-thiophene-2-carbonyl-S-CoA + paromomycin
?
show the reaction diagram
-
-
-
-
?
4-bromo-thiophene-2-carbonyl-S-CoA + tobramycin
?
show the reaction diagram
-
-
-
-
?
5-bromo-thiophene-2-carbonyl-S-CoA + kanamycin A
?
show the reaction diagram
-
-
-
-
?
5-bromo-thiophene-2-carbonyl-S-CoA + neomycin B
?
show the reaction diagram
-
-
-
-
?
6-fluoropicolinyl-CoA + neomycin B
?
show the reaction diagram
-
-
-
-
?
acetyl-CoA + a 2-deoxystreptamine antibiotic
CoA + N3-acetyl-2-deoxystreptamine antibiotic
show the reaction diagram
acetyl-CoA + amikacin
CoA + N3'-acetyl-amikacin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + amikacin
CoA + N3'-acetylamikacin
show the reaction diagram
acetyl-CoA + aminoglycoside-aminocyclitol
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + apramycin
CoA + N3'-acetylapramycin
show the reaction diagram
acetyl-CoA + butirosin
CoA + N3'-acetylbutirosin
show the reaction diagram
-
-
-
?
acetyl-CoA + dactimicin
CoA + N4-acetyldactamicin + N4,N6'-diacetyldactimicin
show the reaction diagram
-
the percentage of dactimicin affinity relative to gentamicin C1a is very high (74.6%) only with AAC(3)-I, to the most other enzymes tested, in spite of the bifunctional AAC(6')/APH(2''), dactamicin is stable
-
-
?
acetyl-CoA + dibekacin
CoA + N3''-acetyldibekacin
show the reaction diagram
acetyl-CoA + dibekacin
CoA + N3-acetyldibekacin
show the reaction diagram
acetyl-CoA + fortimicin
CoA + N3-acetylfortimicin
show the reaction diagram
-
-
-
?
acetyl-CoA + gentamicin
CoA + N3'-acetyl-gentamicin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + gentamicin
CoA + N3'-acetylgentamicin
show the reaction diagram
acetyl-CoA + gentamicin A
CoA + N3'-acetylgentamicin A
show the reaction diagram
-
acetylation at 6% the rate of gentamicin C1
-
-
?
acetyl-CoA + gentamicin C
CoA + N3'-acetylgentamicin C
show the reaction diagram
-
acetylation at 86% the rate of gentamicin C1
-
-
?
acetyl-CoA + gentamicin C1
CoA + N3'-acetylgentamicin C1
show the reaction diagram
acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
show the reaction diagram
acetyl-CoA + gentamicin C1A
CoA + N3-acetylgentamicin C1A
show the reaction diagram
-
-
-
?
acetyl-CoA + gentamicin C2
CoA + N3'-acetylgentamicin C2
show the reaction diagram
acetyl-CoA + isepamycin
CoA + N3'-acetylisepamycin
show the reaction diagram
wild-type and recombinant enzyme
-
?
acetyl-CoA + kanamycin
CoA + N3'-acetylkanamycin
show the reaction diagram
acetyl-CoA + kanamycin A
CoA + N3'-acetylkanamycin A
show the reaction diagram
acetyl-CoA + kanamycin B
CoA + N3'-acetylkanamycin B
show the reaction diagram
acetyl-CoA + kanamycin B
CoA + N3-acetylkanamycin B
show the reaction diagram
acetyl-CoA + lividomycin A
CoA + ?
show the reaction diagram
-
-
-
-
?
acetyl-CoA + neomycin
CoA + ?
show the reaction diagram
-
-
-
?
acetyl-CoA + neomycin
CoA + N2'-acetylneomycin
show the reaction diagram
wild-type and recombinant enzyme
-
?
acetyl-CoA + neomycin
CoA + N3-acetylneomycin
show the reaction diagram
-
-
-
?
acetyl-CoA + neomycin B
CoA + ?
show the reaction diagram
acetyl-CoA + neomycin B
CoA + N3-acetyl-neomycin B
show the reaction diagram
acetyl-CoA + neomycin B
CoA + N3-acetylneomycin B
show the reaction diagram
-
-
-
-
?
acetyl-CoA + netilmicin
CoA + N3'-acetylnetilmicin
show the reaction diagram
acetyl-CoA + paromomycin
CoA + N3'-acetyl-paromomycin
show the reaction diagram
acetyl-CoA + paromomycin
CoA + N3'-acetylparomomycin
show the reaction diagram
-
-
-
?
acetyl-CoA + paromomycin
CoA + N3-acetylparamomycin
show the reaction diagram
-
-
-
?
acetyl-CoA + ribostamycin
CoA + ?
show the reaction diagram
acetyl-CoA + ribostamycin
CoA + N3-acetylribostamycin
show the reaction diagram
-
-
-
?
acetyl-CoA + sisomicin
CoA + N3'-acetyl-sisomicin
show the reaction diagram
acetyl-CoA + sisomicin
CoA + N3'-acetylsisomicin
show the reaction diagram
acetyl-CoA + sisomicin
CoA + N3-acetylsisomicin
show the reaction diagram
-
-
-
?
acetyl-CoA + sisomycin
CoA + N3'-acetylsisomycin
show the reaction diagram
acetyl-CoA + spectinomycin
CoA + N3'-acetylspectinomycin
show the reaction diagram
wild-type and recombinant enzyme
-
?
acetyl-CoA + streptomycin
CoA + ?
show the reaction diagram
wild-type and recombinant enzyme
-
?
acetyl-CoA + tobramycin
CoA + N3'-acetyl-tobramycin
show the reaction diagram
-
-
-
-
?
acetyl-CoA + tobramycin
CoA + N3'-acetyltobramycin
show the reaction diagram
acetyl-CoA + tobramycin
CoA + N3-acetyltobramycin
show the reaction diagram
-
-
-
?
butyryl-CoA + kanamycin A
CoA + N3'-butyryl-kanamycin A
show the reaction diagram
-
-
-
-
?
butyryl-CoA + ribostamycin
CoA + ?
show the reaction diagram
-
-
-
?
desulfo-CoA + ribostamycin
?
show the reaction diagram
-
-
-
?
glutaryl-CoA + kanamycin A
?
show the reaction diagram
-
-
-
-
?
glycyl-CoA + amikacin
CoA + N3'-glycyl-amikacin
show the reaction diagram
-
-
-
-
?
glycyl-CoA + gentamicin
CoA + N3'-glycyl-gentamicin
show the reaction diagram
-
-
-
-
?
glycyl-CoA + kanamycin A
CoA + N3'-glycyl-kanamycin A
show the reaction diagram
-
-
-
-
?
glycyl-CoA + neomycin B
CoA + N3-glycylneomycin B
show the reaction diagram
-
-
-
-
?
glycyl-CoA + sisomicin
CoA + N3'-glycyl-sisomicin
show the reaction diagram
-
-
-
-
?
malonyl-CoA + amikacin
CoA + N3'-malonyl-amikacin
show the reaction diagram
-
-
-
-
?
malonyl-CoA + gentamicin
CoA + N3'-malonyl-gentamicin
show the reaction diagram
-
-
-
-
?
malonyl-CoA + kanamycin A
CoA + N3'-malonylkanamycin A
show the reaction diagram
-
-
-
-
?
malonyl-CoA + neomycin B
CoA + N3-malonylneomycin B
show the reaction diagram
-
-
-
-
?
malonyl-CoA + ribostamycin
CoA + ?
show the reaction diagram
-
-
-
?
methylmalonyl-CoA + neomycin B
CoA + N3-methylmalonylneomycin B
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + amikacin
CoA + N3'-propionyl-amikacin
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + gentamicin
CoA + N3'-propionyl-gentamicin
show the reaction diagram
-
-
-
-
?
n-propionyl-CoA + kanamycin A
CoA + N3'-n-propionylkanamycin A
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + kanamycin A
CoA + N3'-propionyl-kanamycin A
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + neomycin B
CoA + N3-propionylneomycin B
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + paromomycin
CoA + N3'-propionyl-paromomycin
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + sisomicin
CoA + N3'-propionyl-sisomicin
show the reaction diagram
-
-
-
-
?
N-propionyl-CoA + tobramycin
CoA + N3'-propionyl-tobramycin
show the reaction diagram
-
-
-
-
?
propionyl-CoA + ribostamycin
CoA + ?
show the reaction diagram
-
-
-
?
additional information
?
-