2.3.1.81: aminoglycoside 3-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3-N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

3'-aminoglycoside acetyltransferase, 3-N-acetyltransferase, 3-N-aminoglycoside acetyltransferase, AAC, AAC (3)-IIIb, AAC(3), AAC(3)-Id, AAC(3)-Ig acetyltransferase, Aac(3)-IIIb, AAC(3)-IV, AAC(3)-XI, AAC(6')-APH(2''), AAC-IIIb, AAC-VIa, aac3-Ia, AAC3-IV aminoglycoside acetyltransferase, AacC-A7 acetyltransferase, aminoglycoside 3-acetyltransferase, aminoglycoside 3-acetyltransferase-IIIb, aminoglycoside 3-N-acetyltransferase, aminoglycoside 3-N-acetyltransferase type XI, aminoglycoside acetyltransferase, aminoglycoside acetytransferase, aminoglycoside N(3)-acetyltransferase III, aminoglycoside N3-acetyltransferase, aminoglycoside N3-acetyltransferase-IIIb, aminoglycoside N3-acetyltransferase-VIa, Eis, Eis2, Enhanced in Intracellular Survival, More, RbmI

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.81 aminoglycoside 3-N-acetyltransferase

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Results	in table
6278	AA Sequence
5	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
9	Disease/ Diagnostics
7	General Information
3	General Stability
2	IC50 Value
29	Inhibitors
27	kcat/KM [mM/s]
2	Ki Value [mM]
71	KM Value [mM]
7	Localization
3	Metals/Ions
8	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
45	Organism
77	PDB ID
4	pH Optimum
1	pI Value
1	Posttranslational Modification
2	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
171	Substrates and Products (Substrate)
3	Subunits
52	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

General Information

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General Information on EC 2.3.1.81 - aminoglycoside 3-N-acetyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

2 entries

physiological function

4 entries

additional information

Acinetobacter baumannii

P29807

presence of genes encoding the following aminoglycoside-modifying en­zymes: aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resis­tance in 4 different groups of clinical isolates, overview

736260

evolution

Corynebacterium striatum

A0A0K2X0F2

aminoglycoside 3-N-acetyltransferases [AAC(3)] are widely distributed in Gram-negative bacteria and are categorized in five types (I, II, III, IV, and VI). To date, only four are identified in the Gram-positive aminoglycoside producers, overview

735448

evolution

Corynebacterium striatum BM4687

-

aminoglycoside 3-N-acetyltransferases [AAC(3)] are widely distributed in Gram-negative bacteria and are categorized in five types (I, II, III, IV, and VI). To date, only four are identified in the Gram-positive aminoglycoside producers, overview

-

physiological function

Corynebacterium striatum

A0A0K2X0F2

expression in Escherichia coli confers resistance to gentamicin, tobramycin, sisomicin, dibekacin, and fortimicin, the MICs of kanamycin A, netilmicin, amikacin, apramycin, and neomycin B remaining unchanged

735448

physiological function

Mycobacterium tuberculosis

P9WFK7

acetyltransferase Eis upregulation causes resistance to kanamycin A in Mycobacterium tuberculosis

757385

physiological function

Corynebacterium striatum BM4687

-

expression in Escherichia coli confers resistance to gentamicin, tobramycin, sisomicin, dibekacin, and fortimicin, the MICs of kanamycin A, netilmicin, amikacin, apramycin, and neomycin B remaining unchanged

-

physiological function

Mycobacterium tuberculosis H37Rv

-

acetyltransferase Eis upregulation causes resistance to kanamycin A in Mycobacterium tuberculosis

-