2.3.1.81: aminoglycoside 3-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 3-N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

3'-aminoglycoside acetyltransferase, 3-N-acetyltransferase, 3-N-aminoglycoside acetyltransferase, AAC, AAC (3)-IIIb, AAC(3), AAC(3)-Id, AAC(3)-Ig acetyltransferase, Aac(3)-IIIb, AAC(3)-IV, AAC(3)-XI, AAC(6')-APH(2''), AAC-IIIb, AAC-VIa, aac3-Ia, AAC3-IV aminoglycoside acetyltransferase, AacC-A7 acetyltransferase, aminoglycoside 3-acetyltransferase, aminoglycoside 3-acetyltransferase-IIIb, aminoglycoside 3-N-acetyltransferase, aminoglycoside 3-N-acetyltransferase type XI, aminoglycoside acetyltransferase, aminoglycoside acetytransferase, aminoglycoside N(3)-acetyltransferase III, aminoglycoside N3-acetyltransferase, aminoglycoside N3-acetyltransferase-IIIb, aminoglycoside N3-acetyltransferase-VIa, Eis, Eis2, Enhanced in Intracellular Survival, More, RbmI

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.81 aminoglycoside 3-N-acetyltransferase

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Results	in table
6278	AA Sequence
5	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
9	Disease/ Diagnostics
7	General Information
3	General Stability
2	IC50 Value
29	Inhibitors
27	kcat/KM [mM/s]
2	Ki Value [mM]
71	KM Value [mM]
7	Localization
3	Metals/Ions
8	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
45	Organism
77	PDB ID
4	pH Optimum
1	pI Value
1	Posttranslational Modification
2	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
1	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
171	Substrates and Products (Substrate)
3	Subunits
52	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.3.1.81 - aminoglycoside 3-N-acetyltransferase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with inhibitor N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinesulfonamide. Inhibitor binds Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37) bearing key hydrophobic residues

Mycobacterium tuberculosis

P9WFK7

757385

structures of apo-enzyme and in complex with acetyl-CoA

Mycobacteroides abscessus

B1MKV6

756710

in the apo form, in binary drug (sisomicin, neomycin, and paromomycin) and coenzyme A complexes, and in the ternary neomycin-CoASH complex

Pseudomonas aeruginosa

Q51405

757396

X-ray structure of a recombinant enzyme, expressed in its selenomethionine substituted form, cocrystallization with 5 mM CoA at 4°C and pH: 7.8, crystal cryoprotection achieved with 17% glycerol and 8% 2R,3R-butanediol, active center found by X-ray analysis and model building

Serratia marcescens

-

487550