2.3.1.8: phosphate acetyltransferase
This is an abbreviated version!
For detailed information about phosphate acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.8
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2.3.1.8
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acetyl-coenzyme
-
methanosarcina
-
thermophila
-
formate-lyase
-
acetobutylicum
-
pta-ack
-
acetogenic
-
coash
-
acka-pta
-
2.7.2.1
-
phosphoketolase
-
acetoin
-
acetate-activating
-
butyryl-coa
-
tyrobutyricum
-
substrate-level
-
2,3-butanediol
-
acetate-grown
-
acetylphosphate
-
sulfoacetaldehyde
-
synthesis
-
biotechnology
-
biofuel production
- 2.3.1.8
-
acetyl-coenzyme
- methanosarcina
- thermophila
- formate-lyase
- acetobutylicum
-
pta-ack
-
acetogenic
- coash
-
acka-pta
-
2.7.2.1
- phosphoketolase
- acetoin
-
acetate-activating
- butyryl-coa
- tyrobutyricum
-
substrate-level
- 2,3-butanediol
-
acetate-grown
- acetylphosphate
- sulfoacetaldehyde
- synthesis
- biotechnology
- biofuel production
Reaction
Synonyms
acetyl-S-CoA: orthophosphate acetyltransferase, acetyltransferase, phosphate, aster yellows witches'-broom phosphotransacetylase-like enzyme, AYWB-PduL, EutD, Moth_0864, Moth_1181, pduL1, pduL2, PGN_1179, phosphate acetyltransferase, phosphoacylase, phosphotransacetylase, phosphotransacetylase EutD, phosphotransacetylase Pta, PTA, Pta-1, Pta-2, PtaII1, PtaII2
ECTree
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Reference on EC 2.3.1.8 - phosphate acetyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Preston, G.G.; Zeiher, C.; Wall, J.D.; Emerich, D.W.
Acetate-activating enzymes of Bradyrhizobium japonicum bacteroids
Appl. Environ. Microbiol.
55
165-170
1989
Bradyrhizobium japonicum
Stadtman, E.R.
Phosphotransacetylase from Clostridium kluyveri
Methods Enzymol.
1
596-599
1955
Clostridium kluyveri
-
Bergmeyer, H.U.; Holz, G.; Klotsch, H.; Lang, G.
Phosphotransacetylase aus Clostridium kluyveri
Biochem. Z.
338
114-121
1963
Clostridium kluyveri
Stadtman, E.R.
The purification and properties of phosphotransacetylase
J. Biol. Chem.
196
527-534
1952
Clostridium kluyveri
Duhr, E.F.; Owens, M.S.; Barden, R.E.
Irreversible inhibition of phosphotransacetylase by S-dimethylarsino-CoA
Biochim. Biophys. Acta
749
84-90
1983
Clostridium kluyveri
Kreuzberg, K.; Umlauf, H.; Blaschkowski, H.P.
Purification and properties of phosphotransacetylase from the eucaryotic green alga Chlorogonium elongatum
Biochim. Biophys. Acta
842
22-29
1985
Chlorogonium elongatum
-
Henkin, J.; Abeles, R.H.
Evidence against an acyl-enzyme intermediate in the reaction catalyzed by clostridial phosphotransacetylase
Biochemistry
15
3472-3479
1976
Clostridium kluyveri
Kyrtopoulos, S.A.; Satchell, D.P.N.
Kinetic studies with phosphotransacetylase. V. The mechanism of activation by univalent cations
Biochim. Biophys. Acta
321
126-142
1973
Clostridium kluyveri
Kyrtopoulos, S.A.; Satchell, D.P.N.
Kinetic studies with phosphotransacetylase. II. The acetylation of arsenate by acetyl coenzyme A
Biochim. Biophys. Acta
268
334-343
1972
Clostridium kluyveri
Hibbert, F.; Kyrtopoulos, S.A.; Satchell, D.P.N.
Kinetic studies with phosphotransacetylase
Biochim. Biophys. Acta
242
39-54
1971
Clostridium kluyveri
Pelroy, R.A.; Whiteley, H.R.
Kinetic properties of phosphotransacetylase from Veillonella alcalescens
J. Bacteriol.
111
47-55
1972
Veillonella parvula
Whiteley, H.R.; Pelroy, R.A.
Purification and properties of phosphotransacetylase from Veillonella alcalescens
J. Biol. Chem.
247
1911-1917
1972
Veillonella parvula
Drake, H.L.; Hu, S.I.; Wood, H.G.
Purification of five components from Clostridium thermoaceticum which catalyze synthesis of acetate from pyruvate and methyltetrahydrofolate. Properties of phosphotransacetylase
J. Biol. Chem.
256
11137-11144
1981
Moorella thermoacetica
Vigenschow, H.; Schwarm, H.M.; Knobloch, K.
Purification and characterization of a phosphotransacetylase from Rhodopseudomonas palustris
Biol. Chem. Hoppe-Seyler
367
957-962
1986
Rhodopseudomonas palustris
Lundie, L.L.; Ferry, J.G.
Activation of acetate by Methanosarcina thermophila. Purification and characterization of phosphotransacetylase
J. Biol. Chem.
264
18392-18396
1989
Methanosarcina thermophila
Rado, T.A.; Hoch, J.A.
Phosphotransacetylase from Bacillus subtilis: purification and physiological studies
Biochim. Biophys. Acta
321
114-125
1973
Bacillus subtilis
Robinson, J.R.; Sagers, R.D.
Phosphotransacetylase from Clostridium acidiurici
J. Bacteriol.
112
465-473
1972
Gottschalkia acidurici
Smith, L.T.; Kaplan, N.O.
Purification of phosphotransacetylase by affinity chromatography
Anal. Biochem.
95
2-7
1979
Clostridium kluyveri
Shimizu, M.; Suzuki, T.; Kameda, K.Y.; Abiko, Y.
Phosphotransacetylase of Escherichia coli B, purification and properties
Biochim. Biophys. Acta
191
550-558
1969
Escherichia coli
Suzuki, T.
Phosphotransacetylase of Escherichia coli B, activation by pyruvate and inhibition by NADH and certain nucleotides
Biochim. Biophys. Acta
191
559-569
1969
Escherichia coli
Nojiri, T.; Tanaka, F.; Nakayama, I.
Purification and properties of phosphotransacetylase from Lactobacillus fermenti
J. Biochem.
69
789-801
1971
Limosilactobacillus fermentum, Limosilactobacillus fermentum DSM 20391
Kyrtopoulos, S.A.; Satchell, D.P.N.
Kinetic studies with phosphotransacetylase. 3. The acylation of phosphate ions by acetyl coenzyme A
Biochim. Biophys. Acta
276
376-382
1972
Clostridium kluyveri
Kyrtopoulos, S.A.; Satchell, D.P.N.
Kinetic studies with phosphotransacetylase. IV. Inhibition by products
Biochim. Biophys. Acta
276
383-391
1972
Clostridium kluyveri
Bresters, T.W.; Krul, J.; Scheepens, P.C.; Veeger, C.
Phosphotransacetylase associated with the pyruvate dehydrogenase complex from the nitrogen fixing Azotobacter vinelandii
FEBS Lett.
22
305-309
1972
Azotobacter vinelandii
Bock, A.K.; Glasemacher, J.; Schmidt, R.; Schonheit, P.
Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima
J. Bacteriol.
181
1861-1867
1999
Thermotoga maritima
Boynton, Z.L.; Bennett, G.N.; Rudolph, F.B.
Cloning, sequencing, and expression of genes encoding phosphotransacetylase and acetate kinase from Clostridium acetobutylicum ATCC 824
Appl. Environ. Microbiol.
62
2758-2766
1996
Clostridium acetobutylicum
Iyer, P.P.; Ferry, J.G.
Role of arginines in coenzyme A binding and catalysis by the phosphotransacetylase from Methanosarcina thermophila
J. Bacteriol.
183
4244-4250
2001
Methanosarcina thermophila
Knorr, R.; Ehrmann, M.A.; Vogel, R.F.
Cloning of the phosphotransacetylase gene from Lactobacillus sanfranciscensis and characterization of its gene product
J. Basic Microbiol.
41
339-349
2001
Fructilactobacillus sanfranciscensis
Latimer, M.T.; Ferry, J.G.
Cloning, sequence analysis, and hyperexpression of the genes encoding phosphotransacetylase and acetate kinase from Methanosarcina thermophila
J. Bacteriol.
175
6822-6829
1993
Methanosarcina thermophila, Methanosarcina thermophila TM-1
Rasche, M.E.; Smith, K.S.; Ferry, J.G.
Identification of cysteine and arginine residues essential for the phosphotransacetylase from Methanosarcina thermophila
J. Bacteriol.
179
7712-7717
1997
Methanosarcina thermophila
Shin, B.S.; Choi, S.K.; Park, S.H.
Regulation of the Bacillus subtilis phosphotransacetylase gene
J. Biochem.
126
333-339
1999
Bacillus subtilis
Summers, M.L.; Denton, M.C.; McDermott, T.R.
Genes coding for phosphotransacetylase and acetate kinase in Sinorhizobium meliloti are in an operon that is inducible by phosphate stress and controlled by PhoB
J. Bacteriol.
181
2217-2224
1999
Sinorhizobium meliloti
Iyer, P.P.; Lawrence, S.H.; Yennawar, H.P.; Ferry, J.G.
Expression, purification, crystallization and preliminary X-ray analysis of phosphotransacetylase from Methanosarcina thermophila
Acta Crystallogr. Sect. D
59
1517-1520
2003
Methanosarcina thermophila
Brinsmade, S.R.; Escalante-Semerena, J.C.
The eutD gene of Salmonella enterica encodes a protein with phosphotransacetylase enzyme activity
J. Bacteriol.
186
1890-1892
2004
Salmonella enterica
Xu, Q.S.; Shin, D.H.; Pufan, R.; Yokota, H.; Kim, R.; Kim, S.H.
Crystal structure of a phosphotransacetylase from Streptococcus pyogenes
Proteins
55
479-481
2004
Streptococcus pyogenes
Iyer, P.P.; Lawrence, S.H.; Luther, K.B.; Rajashankar, K.R.; Yennawar, H.P.; Ferry, J.G.; Schindelin, H.
Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila
Structure
12
559-567
2004
Methanosarcina thermophila
Kim, Y.R.; Brinsmade, S.R.; Yang, Z.; Escalante-Semerena, J.; Fierer, J.
Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice
Infect. Immun.
74
2498-2502
2006
Salmonella enterica
Lawrence, S.H.; Luther, K.B.; Schindelin, H.; Ferry, J.G.
Structural and functional studies suggest a catalytic mechanism for the phosphotransacetylase from Methanosarcina thermophila
J. Bacteriol.
188
1143-1154
2006
Methanosarcina thermophila (P38503), Methanosarcina thermophila
Lawrence, S.H.; Ferry, J.G.
Steady-state kinetic analysis of phosphotransacetylase from Methanosarcina thermophila
J. Bacteriol.
188
1155-1158
2006
Methanosarcina thermophila
Brinsmade, S.R.; Escalante-Semerena, J.C.
In vivo and in vitro analyses of single-amino acid variants of the Salmonella enterica phosphotransacetylase enzyme provide insights into the function of its N-terminal domain
J. Biol. Chem.
282
12629-12640
2007
Salmonella enterica
Xu, Q.S.; Jancarik, J.; Lou, Y.; Kuznetsova, K.; Yakunin, A.F.; Yokota, H.; Adams, P.; Kim, R.; Kim, S.H.
Crystal structures of a phosphotransacetylase from Bacillus subtilis and its complex with acetyl phosphate
J. Struct. Funct. Genomics
6
269-279
2005
Bacillus subtilis
Starai, V.J.; Garrity, J.; Escalante-Semerena, J.C.
Acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities
Microbiology
151
3793-3801
2005
Salmonella enterica (P41790), Salmonella enterica (Q8ZND6), Salmonella enterica
Gorzynska, A.K.; Denger, K.; Cook, A.M.; Smits, T.H.
Inducible transcription of genes involved in taurine uptake and dissimilation by Silicibacter pomeroyi DSS-3T
Arch. Microbiol.
185
402-406
2006
Ruegeria pomeroyi (Q5LMK3)
Veit, A.; Rittmann, D.; Georgi, T.; Youn, J.W.; Eikmanns, B.J.; Wendisch, V.F.
Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum
J. Biotechnol.
140
75-83
2009
Corynebacterium glutamicum
Castano-Cerezo, S.; Pastor, J.; Renilla, S.; Bernal, V.; Iborra, J.; Canovas, M.
An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli
Microb. Cell Fact.
8
54
2009
Escherichia coli, Escherichia coli BW25113
Nemeti, B.; Gregus, Z.
Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: I. The role of arsenolysis
Toxicol. Sci.
110
270-281
2009
Clostridium kluyveri, Methanosarcina thermophila
Gregus, Z.; Roos, G.; Geerlings, P.; Nemeti, B.
Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiols
Toxicol. Sci.
110
282-292
2009
Methanosarcina thermophila
Campos-Bermudez, V.A.; Bologna, F.P.; Andreo, C.S.; Drincovich, M.F.
Functional dissection of Escherichia coli phosphotransacetylase structural domains and analysis of key compounds involved in activity regulation
FEBS J.
277
1957-1966
2010
Escherichia coli (P0A9M8), Escherichia coli
Bologna, F.P.; Campos-Bermudez, V.A.; Saavedra, D.D.; Andreo, C.S.; Drincovich, M.F.
Characterization of Escherichia coli EutD: a phosphotransacetylase of the ethanolamine operon
J. Microbiol.
48
629-636
2010
Escherichia coli
Dimou, M.; Venieraki, A.; Liakopoulos, G.; Katinakis, P.
Cloning, characterization and transcriptional analysis of two phosphate acetyltransferase isoforms from Azotobacter vinelandii
Mol. Biol. Rep.
38
3653-3663
2011
Azotobacter vinelandii (C1DER7), Azotobacter vinelandii (C1DQG8), Azotobacter vinelandii
Dimou, M.; Venieraki, A.; Zografou, C.; Katinakis, P.
The cytoplasmic cyclophilin from Azotobacter vinelandii interacts with phosphate acetyltransferase isoforms enhancing their in vitro activity
Mol. Biol. Rep.
39
4135-4143
2012
Azotobacter vinelandii (C1DER7), Azotobacter vinelandii (C1DQG8), Azotobacter vinelandii
Kushkevych, I.V.
Activity and kinetic properties of phosphotransacetylase from intestinal sulfate-reducing bacteria
Acta Biochim. Pol.
62
103-108
2015
Desulfovibrio piger, Desulfomicrobium sp., Desulfomicrobium sp. Rod-9, Desulfovibrio piger Vib-7
Argyros, D.A.; Tripathi, S.A.; Barrett, T.F.; Rogers, S.R.; Feinberg, L.F.; Olson, D.G.; Foden, J.M.; Miller, B.B.; Lynd, L.R.; Hogsett, D.A.; Caiazza, N.C.
High ethanol titers from cellulose by using metabolically engineered thermophilic, anaerobic microbes
Appl. Environ. Microbiol.
77
8288-8294
2011
Acetivibrio thermocellus (O52593), Acetivibrio thermocellus, Acetivibrio thermocellus DSM 1237 (O52593)
Taylor, T.; Ingram-Smith, C.; Smith, K.S.
Biochemical and Kinetic Characterization of the eukaryotic phosphotransacetylase class IIa enzyme from Phytophthora ramorum
Eukaryot. Cell
14
652-660
2015
Phytophthora ramorum
Saigo, M.; Golic, A.; Alvarez, C.E.; Andreo, C.S.; Hogenhout, S.A.; Mussi, M.A.; Drincovich, M.F.
Metabolic regulation of phytoplasma malic enzyme and phosphotransacetylase supports the use of malate as an energy source in these plant pathogens
Microbiology
160
2794-2806
2014
Candidatus Phytoplasma
Patil, Y.; Junghare, M.; Müller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum
Breitkopf, R.; Uhlig, R.; Drenckhan, T.; Fischer, R.J.
Two propanediol utilization-like proteins of Moorella thermoacetica with phosphotransacetylase activity
Extremophiles
20
653-661
2016
Moorella thermoacetica (Q2RJ94), Moorella thermoacetica (Q2RK58), Moorella thermoacetica
Varma, P.; Adimulam, Y.; Subrahmanyam, K.
In silico virtual screening of PubChem compounds against phosphotransacetylase, a putative drug target for Staphylococcus aureus
Int. J. Comput. Biol. Drug Des.
10
39-48
2017
Staphylococcus aureus (Q6GJ80), Staphylococcus aureus MRSA 252 (Q6GJ80)
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Yoshida, Y.; Sato, M.; Nonaka, T.; Hasegawa, Y.; Kezuka, Y.
Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis
J. Oral Microbiol.
11
1588086
2019
Porphyromonas gingivalis (B2RK03), Porphyromonas gingivalis, Porphyromonas gingivalis ATCC 33277 (B2RK03)
Yang, X.; Sun, W.; Shen, H.; Zhang, S.; Jiao, X.; Zhao, Z.
Expression of phosphotransacetylase in Rhodosporidium toruloides leading to improved cell growth and lipid production
RSC Adv.
8
24673-24678
2018
Bacillus subtilis
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