2.3.1.8: phosphate acetyltransferase
This is an abbreviated version!
For detailed information about phosphate acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.8
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2.3.1.8
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acetyl-coenzyme
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methanosarcina
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thermophila
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formate-lyase
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acetobutylicum
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pta-ack
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acetogenic
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coash
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acka-pta
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2.7.2.1
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phosphoketolase
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acetoin
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acetate-activating
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butyryl-coa
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tyrobutyricum
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substrate-level
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2,3-butanediol
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acetate-grown
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acetylphosphate
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sulfoacetaldehyde
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synthesis
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biotechnology
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biofuel production
- 2.3.1.8
-
acetyl-coenzyme
- methanosarcina
- thermophila
- formate-lyase
- acetobutylicum
-
pta-ack
-
acetogenic
- coash
-
acka-pta
-
2.7.2.1
- phosphoketolase
- acetoin
-
acetate-activating
- butyryl-coa
- tyrobutyricum
-
substrate-level
- 2,3-butanediol
-
acetate-grown
- acetylphosphate
- sulfoacetaldehyde
- synthesis
- biotechnology
- biofuel production
Reaction
Synonyms
acetyl-S-CoA: orthophosphate acetyltransferase, acetyltransferase, phosphate, aster yellows witches'-broom phosphotransacetylase-like enzyme, AYWB-PduL, EutD, Moth_0864, Moth_1181, pduL1, pduL2, PGN_1179, phosphate acetyltransferase, phosphoacylase, phosphotransacetylase, phosphotransacetylase EutD, phosphotransacetylase Pta, PTA, Pta-1, Pta-2, PtaII1, PtaII2
ECTree
2.3.1.8 phosphate acetyltransferaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.3.1.8 - phosphate acetyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2,3-Butanedione
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almost complete loss of wild-type enzyme activity after 10 min at 10 mM
2-[(1S)-1-[(N-acetyl-L-alanyl)amino]ethyl]-1,3-oxazol-5-yl diphenyl phosphate
inhibitor identified by in silico screening, dock score -191.515 kcal/mol
MgCl2
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activation at low concentration, inhibition at high concentration
Phenylglyoxal
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33% inhibition after preincubation with phenylglyoxal
(NH4)2SO4
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activation at low concentration, inhibition at high concentration
acetyl phosphate
substrate inhibition; substrate inhibition
acetyl-CoA
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competitive inhibitor versus CoA when acetyl phosphate is at subsaturating levels but it does not inhibit versus CoA when acetyl phosphate is at saturating levels. Acetyl-CoA is a competitive inhibitor versus acetyl phosphate when CoA is at subsaturating levels but it does not inhibit versus acetyl phosphate when CoA is at saturating levels
coenzyme A
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competitive with respect to acetyl-CoA, non competitive with respect to phosphate
desulfo-CoA
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competitive inhibitor with respect to CoA, noncompetitive inhibitor with respect to acetyl phosphate
Diethylbarbiturate
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potassium diethylbarbiturate buffer, 0.1 M, pH 8.0
Mn2+
0.1 microM, 82% residual activity; 0.2 microM, 40% residual activity
Na+
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acts as inhibitor in the presence of NH4+ or K+, competitive inhibition
NADH
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inhibits by changing enzyme conformation, pyruvate counteracts the inhibitory effect of NADH; inhibits by changing the conformation of the enzyme
phosphate
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competitive with respect to acyl phosphate, non competitive with respect to CoA
phosphate
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competitive inhibitor versus acetyl phosphate when CoA is at saturating or subsaturating levels. Phosphate is a noncompetitive inhibitor versus CoA when acetyl phosphate is at a subsaturating level (0.15 mM), but it does not inhibit versus CoA when acetyl phosphate is at a saturating level (4 mM)
additional information
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fructose-1,6-bisphosphate (1 mM), oxaloacetate (1 mM), 2-oxoglutarate (1.5 mM), and citrate (1.5 mM) have no effect on enzyme activity
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additional information
in silico virtual screening of PubChem compounds with enhanced binding energies when compared with acetyl phosphate
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