2.3.1.78: heparan-alpha-glucosaminide N-acetyltransferase

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For detailed information about heparan-alpha-glucosaminide N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyl-CoA:alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme A-alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase, acetyl-coenzyme:alpha-D-2-amino-glucosamine transferase, acetyltransferase, alpha-glucosaminide, acetyl�coenzyme A:alpha-glucosaminide N-acetyltransferase, GNAT, heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase, heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase, HGSNAT, TMEM76, transmembrane protein 76

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.78 heparan-alpha-glucosaminide N-acetyltransferase

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Results	in table
4	Activating Compound
100	AA Sequence
7	Application
1	CAS Registry Number
7	Cloned(Commentary)
3	Cofactor
115	Disease/ Diagnostics
1	General Information
1	General Stability
34	Inhibitors
15	Ki Value [mM]
8	KM Value [mM]
18	Localization
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
21	Organism
2	Pathway
12	pH Optimum
2	pH Range
1	pI Value
1	Posttranslational Modification
59	Protein Variants
4	Purification (Commentary)
5	Reaction
3	Reaction Type
21	Reference
19	Source Tissue
31	Specific Activity [micromol/min/mg]
2	Storage Stability
42	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Posttranslational Modification

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Posttranslational Modification on EC 2.3.1.78 - heparan-alpha-glucosaminide N-acetyltransferase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

proteolytic modification

Homo sapiens

Q68CP4

enzyme is synthesized as a catalytically inactive 77-kDa precursor that is transported to the lysosomes via an adaptor protein-mediated pathway that involves conserved tyrosine- and dileucine-based lysosomal targeting signals in its C-terminal cytoplasmic domain with a contribution from a dileucine-based signal in the N-terminal cytoplasmic loop. In the lysosome, the precursor is cleaved into a 29-kDa N-terminal alpha-chain and a 48-kDa C-terminal beta-chain, and assembled into active
440-kDa oligomers. The subunits are held together by disulfide bonds between at least two cysteine residues, Cys123 and Cys434, in the lysosomal luminal loops of the enzyme. Proteolytic cleavage may allow the nucleophile residue, His269, in the active site to access the substrate acetyl-CoA in the cytoplasm, for further transfer of the acetyl group to the terminal glucosamine on heparan sulfate

719889