2.3.1.76: retinol O-fatty-acyltransferase
This is an abbreviated version!
For detailed information about retinol O-fatty-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.76
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2.3.1.76
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esterification
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esterify
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retinoids
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medicine
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lecithin:retinol
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palmitate
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palmitoyl-coa
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diacylglycerols
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unesterified
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3hretinol
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hairless
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palmitoyl
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alumina
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chylomicron
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all-trans-retinaldehyde
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dgats
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stearate
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11-cis-retinaldehyde
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11-cis-retinyl
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photobleached
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mid-gestation
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all-trans-retinyl
- 2.3.1.76
- esterification
-
esterify
-
retinoids
- medicine
-
lecithin:retinol
- palmitate
- palmitoyl-coa
- diacylglycerols
-
unesterified
-
3hretinol
- hairless
-
palmitoyl
-
alumina
- chylomicron
- all-trans-retinaldehyde
-
dgats
- stearate
-
11-cis-retinaldehyde
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11-cis-retinyl
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photobleached
-
mid-gestation
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all-trans-retinyl
Reaction
Synonyms
11-cis-acyl-CoA:retinol O-acyltransferase, 11-cis-ARAT, acyl CoA:retinol acyltransferase, acyl CoA:retinol O-acyltransferase, acyl coenzyme A:retinol acyltransferase, acyl-CoA:retinol acyltransferase, ArAT, DGAT1/ARAT, MFAT, More, multifunctional O-acyltransferase, retinol fatty-acyltransferase, retinyl-ester synthase
ECTree
2.3.1.76 retinol O-fatty-acyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.76 - retinol O-fatty-acyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
octanoyl-CoA + retinol
CoA + retinyloctanoate
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-
-
?
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
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esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
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-
?
palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
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esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
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-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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polyunsaturated derivatives are poor substrates
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?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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predominant fatty acid among tissue retinyl esters
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?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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better effect with long chain fatty acids
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?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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better effect with long chain fatty acids
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?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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-
-
?
palmitoyl-CoA + retinol
CoA + retinylpalmitate
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-
-
?
additional information
?
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ARAT may complement LRAT, EC 2.3.1.135, to provide additional retinyl-ester synthase activity under conditions of high all-trans-retinol
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?
additional information
?
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the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin
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-
?
additional information
?
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the multifunctional enzyme plays an important role in lipid metabolism in human skin
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-
?
additional information
?
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acyl coenzyme A:diacylglycerol acyltransferase, DGAT, EC 2.3.1.20, and acyl coenzyme A:monoacylglycerolol acyltransferase, MGAT, EC 2.3.1.22, also show activity with retinol, overview
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-
?
additional information
?
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the multifunctional O-acetyltransferase is catalyzing the reactions of the acyl-CoA:retinol acyltransferase, of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, and of the wax synthase, EC 2.3.1.75, overview
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-
?
additional information
?
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the reaction is also catalyzed by the acyl coenzyme A:diacylglycerol acyltransferase, DGAT, EC 2.3.1.22
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-
?
additional information
?
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ARAT plays a role in retinol metabolism in tissues with low levels of cytosolic retinol binding protein or when cellular retinol concentrations are relatively high, thereby protecting cells from toxicity resulting from excess unesterified retinol
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-
?
additional information
?
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cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity, and the mice have increased levels of unesterified retinol in their livers on a high-retinol diet
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?
additional information
?
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DGAT1 is catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview
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?
additional information
?
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the triacylglycerol synthesis enzyme DGAT1, EC 2.3.1.20, also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters, overview
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