2.3.1.76: retinol O-fatty-acyltransferase
This is an abbreviated version!
For detailed information about retinol O-fatty-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.76
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2.3.1.76
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esterification
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esterify
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retinoids
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medicine
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lecithin:retinol
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palmitate
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palmitoyl-coa
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diacylglycerols
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unesterified
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3hretinol
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hairless
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palmitoyl
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alumina
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chylomicron
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all-trans-retinaldehyde
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dgats
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stearate
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11-cis-retinaldehyde
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11-cis-retinyl
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photobleached
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mid-gestation
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all-trans-retinyl
- 2.3.1.76
- esterification
-
esterify
-
retinoids
- medicine
-
lecithin:retinol
- palmitate
- palmitoyl-coa
- diacylglycerols
-
unesterified
-
3hretinol
- hairless
-
palmitoyl
-
alumina
- chylomicron
- all-trans-retinaldehyde
-
dgats
- stearate
-
11-cis-retinaldehyde
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11-cis-retinyl
-
photobleached
-
mid-gestation
-
all-trans-retinyl
Reaction
Synonyms
11-cis-acyl-CoA:retinol O-acyltransferase, 11-cis-ARAT, acyl CoA:retinol acyltransferase, acyl CoA:retinol O-acyltransferase, acyl coenzyme A:retinol acyltransferase, acyl-CoA:retinol acyltransferase, ArAT, DGAT1/ARAT, MFAT, More, multifunctional O-acyltransferase, retinol fatty-acyltransferase, retinyl-ester synthase
ECTree
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Natural Substrates Products on EC 2.3.1.76 - retinol O-fatty-acyltransferase
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REACTION DIAGRAM
palmitoyl-CoA + 11-cis-retinol
CoA + 11-cis-retinyl palmitate
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esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
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palmitoyl-CoA + all-trans-retinol
CoA + all-trans-retinyl palmitate
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esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
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ARAT may complement LRAT, EC 2.3.1.135, to provide additional retinyl-ester synthase activity under conditions of high all-trans-retinol
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additional information
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the multifunctional O-acyltransferase likely plays an important role in lipid metabolism in human skin
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additional information
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the multifunctional enzyme plays an important role in lipid metabolism in human skin
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additional information
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ARAT plays a role in retinol metabolism in tissues with low levels of cytosolic retinol binding protein or when cellular retinol concentrations are relatively high, thereby protecting cells from toxicity resulting from excess unesterified retinol
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additional information
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cells and tissues from DGAT1-deficient mice exhibit reduced ARAT activity, and the mice have increased levels of unesterified retinol in their livers on a high-retinol diet
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