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2.3.1.74: chalcone synthase

This is an abbreviated version!
For detailed information about chalcone synthase, go to the full flat file.

Word Map on EC 2.3.1.74

Reaction

3 malonyl-CoA +

4-coumaroyl-CoA
= 4 CoA +
naringenin chalcone
 + 3 CO2

Synonyms

6'-deoxychalcone synthase, anther-specific chalcone synthase-like enzyme, ASCL1, ASCL2, chalcone synthase, chalcone synthase 6, chalcone synthase 7, chalcone synthase C2-Idf-I, chalcone synthase C2-Idf-II, chalcone synthetase, CHS, CHS var 2, chs-1, CHS-7, CHS01, CHS02, CHS03, CHS04, CHS05, CHS06, CHS07, CHS08, CHS088, CHS09, Chs1, CHS10, CHS11, CHS12, CHS13, CHS14, Chs2, CHS2 chalcone synthase, CHS3, CHS4, CHS444, CHS5, CHS6, CHS7, CHS768, CHS_H1, Cs-COR126, DOCS, EC 2.3.1.120, flavanone synthase, flavanone synthetase, GmIRCHS, MdCHS2, More, naringenin-chalcone synthase, naringenin-chalcone synthase 6, PgCHS, PKS1, Q7Y1Y0, RinPKS1, RiPKS4, RiPKS5, synthase, flavanone, vsad1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.74 chalcone synthase

Inhibitors

Inhibitors on EC 2.3.1.74 - chalcone synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-methylcyclopropene
-
2'-hydroxygenistein
-
-
2-mercaptoethanol
3'-Nucleotidase
-
i.e. EC 3.1.3.6 hydrolyzes the phosphate group in the 3'-position of adenosine, a part of the CoA thioester substrates
-
4-coumaroyl-CoA
apigenin
Ca2+
-
10-20% decrease at 1 mM
cerulenin
Cu2+
-
50% decrease above 1 mM
Dalbergioidin
-
-
diethyl diphosphate
-
inhibition of wild-type enzyme is pH independent, inhibition of C164S mutant increases with increasing pH between pH 6.2 to pH 7.4
dithiothreitol
-
60% inhibition
eriodictyol
eriodictyol chalcone
-
-
ethylene glycol
-
-
glycerol
-
-
iodoacetamide
iodoacetic acid
-
-
isoliquiritigenin
-
-
isovitexin 2''-O-arabinoside
-
50% inhibition at 0.062 mM
Kievitone
luteolin
malonyl-3'-dephospho-CoA
-
50% inhibition at 0.003 mM
malonyl-CoA
Mg2+
-
10-20% decrease at 1 mM
naringenin
naringenin chalcone
p-chloromercuribenzoate
-
50% inhibition at 2.5 mM
potassium ascorbate
-
-
Zn2+
-
50% decrease above 1 mM