2.3.1.74: chalcone synthase

This is an abbreviated version!
For detailed information about chalcone synthase, go to the full flat file.

Reaction

3 malonyl-CoA +

Synonyms

6'-deoxychalcone synthase, anther-specific chalcone synthase-like enzyme, ASCL1, ASCL2, chalcone synthase, chalcone synthase 6, chalcone synthase 7, chalcone synthase C2-Idf-I, chalcone synthase C2-Idf-II, chalcone synthetase, CHS, CHS var 2, chs-1, CHS-7, CHS01, CHS02, CHS03, CHS04, CHS05, CHS06, CHS07, CHS08, CHS088, CHS09, Chs1, CHS10, CHS11, CHS12, CHS13, CHS14, Chs2, CHS2 chalcone synthase, CHS3, CHS4, CHS444, CHS5, CHS6, CHS7, CHS768, CHS_H1, Cs-COR126, DOCS, EC 2.3.1.120, flavanone synthase, flavanone synthetase, GmIRCHS, MdCHS2, More, naringenin-chalcone synthase, naringenin-chalcone synthase 6, PgCHS, PKS1, Q7Y1Y0, RinPKS1, RiPKS4, RiPKS5, synthase, flavanone, vsad1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.74 chalcone synthase

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Results	in table
17	Activating Compound
1734	AA Sequence
2	Application
1	CAS Registry Number
52	Cloned(Commentary)
5	Crystallization (Commentary)
26	Expression
15	General Information
3	General Stability
56	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
62	KM Value [mM]
17	Localization
1	Metals/Ions
32	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
130	Organism
2	Oxidation Stability
10	Pathway
89	PDB ID
21	pH Optimum
31	pI Value
1	Posttranslational Modification
48	Protein Variants
32	Purification (Commentary)
2	Reaction
1	Reaction Type
117	Reference
112	Source Tissue
13	Specific Activity [micromol/min/mg]
10	Storage Stability
193	Substrates and Products (Substrate)
52	Subunits
118	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
28	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.3.1.74 - chalcone synthase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

hanging-drop vapor-diffusion method using buffered protein solutions (10-15 mg/ml) mixed with equal volumes of the reservoir solution and incubated at 4°C. Crystal structures of biphenyl synthase from Malus domestica and benzophenone synthase from Hypericum androsaemum are compared with the structure of an archetypal type III polyketide synthase - chalcone synthase from Malus domestica

Malus domestica

K9MUA0

755721

hanging-drop vapor-diffusion method, incubation at 4°C. Crystal structures of biphenyl synthase from Malusx02domestica and benzophenone synthase from Hypericum androsaemum are compared with the structure of an archetypal type III polyketide synthase: chalcone synthase from Malus domestica. Both biphenyl synthase and benzophenone synthase contain mutations that reshape their active-site cavities to prevent the binding of 4-coumaroyl-CoA and to favor the binding of small hydrophobic substrates. The active-site cavities of biphenyl synthase and benzophenone synthase also contain a novel pocket associated with their chain-elongation and cyclization reactions

Malus domestica

K9MUA0

755721

-

Medicago sativa

-

487476

using the crstal structure with PDB ID 1BQ6 for structure-function analysis, overview

Medicago sativa

P30074

706814

molecular modeling of structure

Physcomitrium patens

Q2VAZ3

719618