2.3.1.61: dihydrolipoyllysine-residue succinyltransferase

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For detailed information about dihydrolipoyllysine-residue succinyltransferase, go to the full flat file.

Reaction

Synonyms

AceF, dihydrolipoamide acyltransacetylase, dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl succinyltransferase, dihydrolipolyl transsuccinylase, dihydrolipoyl succinyl transferase, dihydrolipoyl succinyltransferase, dihydrolipoyl transsuccinylase, DLST, DSCD, E2 component of alpha-ketoglutarate dehydrogenase complex, E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, E2o, KGD2, lipoate succinyltransferase, lipoic transsuccinylase, lipoyl transsuccinylase, OGDC-E2, SucB, succinyl-CoA:dihydrolipoate S-succinyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.61 dihydrolipoyllysine-residue succinyltransferase

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Results	in table
1	Activating Compound
23436	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
61	Disease/ Diagnostics
1	Expression
13	General Information
2	General Stability
14	IC50 Value
13	Inhibitors
1	kcat/KM [mM/s]
15	KM Value [mM]
16	Localization
1	Metals/Ions
20	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
79	Organism
7	Pathway
88	PDB ID
2	pH Optimum
38	Protein Variants
12	Purification (Commentary)
1	Reaction
2	Reaction Type
78	Reference
1	Renatured (Commentary)
39	Source Tissue
1	Storage Stability
121	Substrates and Products (Substrate)
25	Subunits
56	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.61 - dihydrolipoyllysine-residue succinyltransferase

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SYSTEMATIC NAME

IUBMB Comments

succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.