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2.3.1.61: dihydrolipoyllysine-residue succinyltransferase

This is an abbreviated version!
For detailed information about dihydrolipoyllysine-residue succinyltransferase, go to the full flat file.

Word Map on EC 2.3.1.61

Reaction

succinyl-CoA
+
enzyme N6-(dihydrolipoyl)lysine
=
CoA
+
enzyme N6-(S-succinyldihydrolipoyl)lysine

Synonyms

AceF, dihydrolipoamide acyltransacetylase, dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl succinyltransferase, dihydrolipolyl transsuccinylase, dihydrolipoyl succinyl transferase, dihydrolipoyl succinyltransferase, dihydrolipoyl transsuccinylase, DLST, DSCD, E2 component of alpha-ketoglutarate dehydrogenase complex, E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, E2o, KGD2, lipoate succinyltransferase, lipoic transsuccinylase, lipoyl transsuccinylase, OGDC-E2, SucB, succinyl-CoA:dihydrolipoate S-succinyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.61 dihydrolipoyllysine-residue succinyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.61 - dihydrolipoyllysine-residue succinyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + dihydrolipoamide
CoA + S-succinyldihydrolipoamide
show the reaction diagram
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
show the reaction diagram
additional information
?
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the DLST gene is bifunctionally involved in mitochondrial energy metabolism, the full-length DLST protein is involved in the Krebs cycle and the truncated version, MIRTD, contributes to the biogenesis of the respiratory chain. The genotype of the DLST gene is associated with Alztheimer‘s disease without a change of amino acid residues in the DLST protein: through a decrease in the expression of the truncated gene product MIRTD and the function of MIRTD. It remains unclear how much MIRTD actually contributes to the pathogenesis of Alzheimer‘s disease
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