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2.3.1.6: choline O-acetyltransferase

This is an abbreviated version!
For detailed information about choline O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.6

Reaction

acetyl-CoA
+
choline
=
CoA
 +
O-acetylcholine

Synonyms

acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.6 choline O-acetyltransferase

Source Tissue

Source Tissue on EC 2.3.1.6 - choline O-acetyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
developing antenna during larvae development, enzyme detected in neurons, glia and epidermal cells
Manually annotated by BRENDA team
-
pChAT+ nerve fibers are found exclusively in the trigeminal and solitary systems. The ventral portion of the principal sensory nucleus contains many pChAT+ fibers
Manually annotated by BRENDA team
-
ChAT activity is higher in Ts65Dn mice at both 19 and 24 months of age compared to normogenic animals
Manually annotated by BRENDA team
-
uvea
Manually annotated by BRENDA team
-
lung, fetal lung fibroblasts, HFL-1
Manually annotated by BRENDA team
-
impaired spatial working memory and altered choline acetyltransferase immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
Manually annotated by BRENDA team
-
afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum
Manually annotated by BRENDA team
-
15% of activity membrane associated
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
strong pChAT signal in intrinsic primary afferent neurons, low immunoreactivity for cChAT
Manually annotated by BRENDA team
-
non-neuronal cholinergic cell
Manually annotated by BRENDA team
-
no significant differences of ChAT activity are measured at both 19 and 24 months of age between Ts65Dn mice and normogenic animals
Manually annotated by BRENDA team
-
no significant differences of ChAT activity are measured at both 19 and 24 months of age between Ts65Dn mice and normogenic animals
Manually annotated by BRENDA team
-
enzyme-containing neuronal cell bodies in only two regions, the cell islands of the optic lobe medulla and the cortical layer of the posterior olfactory lobule. Immunoreactive fibers and probable nerve terminals are found in the plexiform layer of the deep retina, within the stroma of the optic gland, and the neuropils of the optic lobe, peduncle lobe, and olfactory lobe
Manually annotated by BRENDA team
-
enzyme-containing neuronal cell bodies in only two regions, the cell islands of the optic lobe medulla and the cortical layer of the posterior olfactory lobule. Immunoreactive fibers and probable nerve terminals are found in the plexiform layer of the deep retina, within the stroma of the optic gland, and the neuropils of the optic lobe, peduncle lobe, and olfactory lobe
Manually annotated by BRENDA team
-
enzyme-containing neuronal cell bodies in only two regions, the cell islands of the optic lobe medulla and the cortical layer of the posterior olfactory lobule. Immunoreactive fibers and probable nerve terminals are found in the plexiform layer of the deep retina, within the stroma of the optic gland, and the neuropils of the optic lobe, peduncle lobe, and olfactory lobe
Manually annotated by BRENDA team
-
afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum
Manually annotated by BRENDA team
-
in both young adult and middle-aged animals, oestradiol treatment initiates immediately after ovariectomy significantly increased ChAT levels in the hippocampus but not in the prefrontal cortex compared to cholesterol control treatment. When oestradiol treatment is initiated 5 months after ovariectomy, it fails to significantly increase ChAT levels in the hippocampus, but does so in the prefrontal cortex
Manually annotated by BRENDA team
-
afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum
Manually annotated by BRENDA team
-
the ganglion neurons possess pChAT, but never cChAT, mRNA and protein. pChAT has enzyme activity enough to supply physiological concentrations of acetylcholine in the ganglion. pChAT contributes both to acetylcholine neurotransmission in physiologically identified cholinergic cells and to functions yet unknown in non-cholinergic neurons
Manually annotated by BRENDA team
-
afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum
Manually annotated by BRENDA team
-
pChAT occurs in most CGRP+ SP+ ganglion cells, such sparseness of pChAT+ fibers implies poor transportation of pChAT to axon branchlets
Manually annotated by BRENDA team
-
dorsal motor nucleus of the vagus nerve, contains a peripheral-type pChAT, a splice variant that lacks exons 6-9 of the common-type ChAT, cChAT
Manually annotated by BRENDA team
additional information