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2.3.1.6: choline O-acetyltransferase

This is an abbreviated version!
For detailed information about choline O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.6

Reaction

acetyl-CoA
+
choline
=
CoA
 +
O-acetylcholine

Synonyms

acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.6 choline O-acetyltransferase

Expression

Expression on EC 2.3.1.6 - choline O-acetyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cerebral spinal fluid enzyme is upregulated in autoimmune neuroinflammation
enzyme activity is reduced significantly when neurons are exposed to high levels of beta-amyloid aggregates
interleukin-1beta induces the enzyme in HFL-1 cells
-
Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression
-
pChAT expression is induced by neuronal damage
-
scopolamine suppresses the enzyme in neurons
-
the administration of 0.5% gamma-aminobutyric acid in the diet of ovariectomized female rats causes an increase in the activity of choline acetyltransferase in the brain