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2.3.1.59: gentamicin 2'-N-acetyltransferase

This is an abbreviated version!
For detailed information about gentamicin 2'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.59

Reaction

acetyl-CoA
+
gentamicin C1a
=
CoA
+
N2'-acetylgentamicin C1a

Synonyms

AAC(2')-Ia, ACC(2'), acetyltransferase, gentamicin 2'-, gentamicin acetyltransferase II

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.59 gentamicin 2'-N-acetyltransferase

Reference

Reference on EC 2.3.1.59 - gentamicin 2'-N-acetyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Benveniste, R.; Davies, J.
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria
Proc. Natl. Acad. Sci. USA
70
2276-2280
1973
Streptomyces kanamyceticus, Streptomyces spectabilis
Manually annotated by BRENDA team
Chevereau, M.; Daniels, P.J.L.; Davies, J.; LeGoffic, F.
Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2-amino group of aminoglycoside antibiotics
Biochemistry
13
598-603
1974
Providencia sp., Providencia sp. 164
Manually annotated by BRENDA team
Payie, K.G.; Clarke, A.J.
Characterization of gentamicin 2'-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan
J. Bacteriol.
179
4106-4114
1997
Providencia stuartii
Manually annotated by BRENDA team
Clarke, A.J.; Francis, D.; Keenleyside, W.J.
The prevalence of gentamicin 2'-N-acetyltransferase in the Proteeae and its role in the O-acetylation of peptidoglycan
FEMS Microbiol. Lett.
145
201-207
1996
no activity in Morganella morganii, no activity in Proteus myxofaciens, no activity in Proteus vulgaris, no activity in Providencia heimbachae, no activity in Providencia rustigianii, Proteus penneri, Providencia rettgeri, Providencia stuartii, Providencia stuartii PR50
Manually annotated by BRENDA team
Payie, K.G.; Strating, H.; Clarke, A.J.
The role of O-acetylation in the metabolism of peptidoglycan in Providencia stuartii
Microb. Drug Resist.
2
135-140
1996
Providencia stuartii
Manually annotated by BRENDA team