2.3.1.59: gentamicin 2'-N-acetyltransferase
This is an abbreviated version!
For detailed information about gentamicin 2'-N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.59
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2.3.1.59
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stuartii
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providencia
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aminoglycoside
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peptidoglycan
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tobramycin
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aac2\'-ia
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beta-galactosidase
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netilmicin
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plazomicin
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o-acetylation
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tetracycline
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chloramphenicol
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ubiquinone
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2\'-amino
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amikacin
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spent
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plasmid-encoded
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proteus
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formers
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coccobacilli
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density-dependent
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analysis
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proteeae
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autolytic
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mid-exponential
- 2.3.1.59
- stuartii
-
providencia
- aminoglycoside
- peptidoglycan
- tobramycin
-
aac2\'-ia
- beta-galactosidase
- netilmicin
-
plazomicin
-
o-acetylation
- tetracycline
- chloramphenicol
- ubiquinone
-
2\'-amino
- amikacin
-
spent
-
plasmid-encoded
-
proteus
-
formers
-
coccobacilli
-
density-dependent
- analysis
-
proteeae
-
autolytic
-
mid-exponential
Reaction
Synonyms
AAC(2')-Ia, ACC(2'), acetyltransferase, gentamicin 2'-, gentamicin acetyltransferase II
ECTree
2.3.1.59 gentamicin 2'-N-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.59 - gentamicin 2'-N-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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the enzyme may contribute to the O-acetylation of peptidoglycan
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additional information
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enzyme may have a physiological role in secondary metabolism, its activity on aminoglycosides is simply fortouitous
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?
additional information
?
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the enzyme contributes to the O-acetylation of peptidoglycan. Mutants that either underexpress or overexpress the aac(2')-Ia gene are characterized phenotypically to possess either lower or higher levels of peptidoglycan O-acetylation, respectively, compared to the wild-type. Providencia stuartii PR100, with 42-44% peptidoglycan O-acetylation compared to 54% of the wild-type, appears as irregular rods. Strains PR50.LM3 and PR51, with increased levels of peptidoglycan O-acetylation, 63% and 65% respectively, appear as coccobacilli or chain formers
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?
additional information
?
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the enzyme may contribute to the O-acetylation of peptidoglycan
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-
?
